A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation. (Q33779634)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20368153%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

title

A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation (English)

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30 January 2020

7

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30 January 2020

6

Robert J Lefkowitz

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30 January 2020

author name string

Diane Gesty-Palmer

1

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30 January 2020

Pat Flannery

2

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30 January 2020

Ling Yuan

3

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30 January 2020

Leonor Corsino

4

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30 January 2020

Robert Spurney

5

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30 January 2020

language of work or name

English

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publication date

1 October 2009

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Science Translational Medicine

30 January 2020

published in

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volume

1

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issue

1

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30 January 2020

page(s)

1ra1

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Functional selectivity through protean and biased agonism: who steers the ship?

30 January 2020

cites work

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Beta-arrestins and cell signaling

4 July 2018

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The use of parathyroid hormone in the treatment of osteoporosis

4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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beta-Arrestin2 regulates the differential response of cortical and trabecular bone to intermittent PTH in female mice

4 July 2018

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Clinical implications of the osteoprotegerin/RANKL/RANK system for bone and vascular diseases.

4 July 2018

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Parathyroid hormone: a double-edged sword for bone metabolism

4 July 2018

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Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system

4 July 2018

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Anabolic effects of a G protein-coupled receptor kinase inhibitor expressed in osteoblasts

4 July 2018

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The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals

4 July 2018

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Parathyroid hormone-dependent signaling pathways regulating genes in bone cells.

4 July 2018

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Internalization determinants of the parathyroid hormone receptor differentially regulate beta-arrestin/receptor association

4 July 2018

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Classical and new roles of beta-arrestins in the regulation of G-protein-coupled receptors

4 July 2018

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Signaling at zero G: G-protein-independent functions for 7-TM receptors

4 July 2018

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Inverse, protean, and ligand-selective agonism: matters of receptor conformation

4 July 2018

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Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds

4 July 2018

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Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3

4 July 2018

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beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2

4 July 2018

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Enhanced morphine analgesia in mice lacking beta-arrestin 2

4 July 2018

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Parathyroid hormone activates mitogen-activated protein kinase in opossum kidney cells

4 July 2018

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Endocytosis of ligand-human parathyroid hormone receptor 1 complexes is protein kinase C-dependent and involves beta-arrestin2. Real-time monitoring by fluorescence microscopy

4 July 2018

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3',5'-Cyclic adenosine monophosphate activation in osteoblastic cells: effects on parathyroid hormone-1 receptors and osteoblastic differentiation in vitro

4 July 2018

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Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes

4 July 2018

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Parathyroid hormone exerts disparate effects on osteoblast differentiation depending on exposure time in rat osteoblastic cells

4 July 2018

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Parathyroid hormone activates mitogen-activated protein kinase via a cAMP-mediated pathway independent of Ras.

4 July 2018

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Inverse agonism of amino-terminally truncated parathyroid hormone (PTH) and PTH-related peptide (PTHrP) analogs revealed with constitutively active mutant PTH/PTHrP receptors

4 July 2018

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4 July 2018

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Cloned, stably expressed parathyroid hormone (PTH)/PTH-related peptide receptors activate multiple messenger signals and biological responses in LLC-PK1 kidney cells

4 July 2018

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4 July 2018

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Effects of continuous and intermittent administration and inhibition of resorption on the anabolic response of bone to parathyroid hormone

4 July 2018

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4 July 2018

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4 July 2018

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Targeted overexpression of G protein-coupled receptor kinase-2 in osteoblasts promotes bone loss.

30 October 2018

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Heptahelical terpsichory. Who calls the tune?

30 October 2018

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12 December 2020

Rickets in cation-sensing receptor-deficient mice: an unexpected skeletal phenotype

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12 December 2020

Evidence that intermittent treatment with parathyroid hormone increases bone formation in adult rats by activation of bone lining cells

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12 December 2020

Truncation of the amino terminus of PTH alters its anabolic activity on bone in vivo

1 reference

12 December 2020

Bone response to intermittent parathyroid hormone is altered in mice null for {beta}-Arrestin2

1 reference

12 December 2020

10.1126/SCITRANSLMED.3000071

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30 January 2020

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30 January 2020

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