PEGylated recombinant human soluble tumour necrosis factor receptor type I (r-Hu-sTNF-RI): novel high affinity TNF receptor designed for chronic inflammatory diseases (Q33782360)

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English	PEGylated recombinant human soluble tumour necrosis factor receptor type I (r-Hu-sTNF-RI): novel high affinity TNF receptor designed for chronic inflammatory diseases	scientific article

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scholarly article

1 reference

Europe PubMed Central

29 July 2017

1 reference

Europe PubMed Central

PEGylated recombinant human soluble tumour necrosis factor receptor type I (r-Hu-sTNF-RI): novel high affinity TNF receptor designed for chronic inflammatory diseases (English)

1 reference

Europe PubMed Central

29 July 2017

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author name string

C K Edwards

1

1 reference

Europe PubMed Central

29 July 2017

language of work or name

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publication date

1 November 1999

1 reference

Europe PubMed Central

29 July 2017

Annals of the Rheumatic Diseases

1 reference

Europe PubMed Central

29 July 2017

58 Suppl 1

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Europe PubMed Central

29 July 2017

I73-81

1 reference

Europe PubMed Central

29 July 2017

Animal models of arthritis: relevance to human disease

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4 July 2018

Biologic agents in the treatment of inflammatory rheumatic diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766570

4 July 2018

The role of tumor necrosis factor in health and disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766570

4 July 2018

Inhibitors of tumor necrosis factor for rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766570

4 July 2018

A casein kinase I motif present in the cytoplasmic domain of members of the tumour necrosis factor ligand family is implicated in 'reverse signalling'

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766570

4 July 2018

Efficacy of sustained blood levels of interleukin-1 receptor antagonist in animal models of arthritis: comparison of efficacy in animal models with human clinical data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766570

4 July 2018

Etanercept therapy in rheumatoid arthritis. A randomized, controlled trial.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766570

4 July 2018

The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766570

4 July 2018

Anti-tumor necrosis factor alpha therapy of rheumatoid arthritis. Mechanism of action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766570

4 July 2018

TNF blockade in rheumatoid arthritis: implications for therapy and pathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766570

4 July 2018

Anti-tumor necrosis factor-alpha therapy of rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766570

4 July 2018

What is the mechanism of action of anti-tumour necrosis factor-alpha antibody in rheumatoid arthritis?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766570

4 July 2018

Role of cytokines in rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766570

4 July 2018

Protection against lethal Escherichia coli bacteremia in baboons (Papio anubis) by pretreatment with a 55-kDa TNF receptor (CD120a)-Ig fusion protein, Ro 45-2081.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766570

4 July 2018

The tumor necrosis factor ligand and receptor families.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766570

4 July 2018

Ligand passing: the 75-kDa tumor necrosis factor (TNF) receptor recruits TNF for signaling by the 55-kDa TNF receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766570

4 July 2018

Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766570

4 July 2018

Protective effect of 55- but not 75-kD soluble tumor necrosis factor receptor-immunoglobulin G fusion proteins in an animal model of gram-negative sepsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766570

4 July 2018

Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766570

4 July 2018

Inhibition of the production and effects of interleukin-1 and tumor necrosis factor alpha in rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766570

4 July 2018

Multifunctional regulation of the biological effects of TNF-alpha by the soluble type I and type II TNF receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766570

4 July 2018

Interleukin-1, tumor necrosis factor and their specific inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766570

4 July 2018

TNF inhibitors are produced spontaneously by rheumatoid and osteoarthritic synovial joint cell cultures: evidence of feedback control of TNF action.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766570

4 July 2018

The inhibitory activity of human interleukin-1 receptor antagonist is enhanced by type II interleukin-1 soluble receptor and hindered by type I interleukin-1 soluble receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766570

4 July 2018

Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766570

4 July 2018

The biology of cachectin/TNF--a primary mediator of the host response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766570

4 July 2018

Cytokine production in the rheumatoid joint: implications for treatment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766570

4 July 2018

Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766570

4 July 2018

A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766570

4 July 2018

Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766570

4 July 2018

Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766570

4 July 2018

Revisiting the role of tumor necrosis factor alpha and the response to surgical injury and inflammation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766570

30 October 2018

Repeated therapy with monoclonal antibody to tumour necrosis factor alpha (cA2) in patients with rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766570

30 October 2018

American College of Rheumatology. Preliminary definition of improvement in rheumatoid arthritis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1766570

30 October 2018

Combination benefit of PEGylated soluble tumor necrosis factor receptor type I (PEG sTNF-RI) and dexamethasone or indomethacin in adjuvant arthritic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/10577978

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PEG-BP-30 Monotherapy Attenuates the Cytokine-Mediated Inflammatory Cascade in Baboon Escherichia coli Septic Shock

1 reference

https://pubmed.ncbi.nlm.nih.gov/10577978

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10577978

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein. The Soluble TNF Receptor Sepsis Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/10577978

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The clinical relevance of circulating tumor necrosis factor-alpha in acute decompensated chronic heart failure without cachexia

1 reference

https://pubmed.ncbi.nlm.nih.gov/10577978

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of 26-kDa cell-associated TNF-alpha in experimental hepatitis and exacerbation of liver injury with a matrix metalloproteinase inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/10577978

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p55 Tumor necrosis factor receptor fusion protein in the treatment of patients with severe sepsis and septic shock. A randomized controlled multicenter trial. Ro 45-2081 Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/10577978

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/10577978

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anticytokine therapy in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10577978

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Concentrations and origins of soluble interleukin 6 receptor-alpha in serum and synovial fluid

1 reference

https://pubmed.ncbi.nlm.nih.gov/10577978

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DBA/1 mice expressing the human TNF-alpha transgene develop a severe, erosive arthritis: characterization of the cytokine cascade and cellular composition

1 reference

https://pubmed.ncbi.nlm.nih.gov/10577978

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TNF inhibition and sepsis — sounding a cautionary note

1 reference

https://pubmed.ncbi.nlm.nih.gov/10577978

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of arthritis and pneumonitis in motheaten mice by soluble tumor necrosis factor receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/10577978

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactivation of streptococcal cell wall-induced arthritis by homologous and heterologous cell wall polymers

1 reference

https://pubmed.ncbi.nlm.nih.gov/10577978

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenosine and a related carbocyclic nucleoside analogue selectively inhibit tumor necrosis factor-alpha production and protect mice against endotoxin challenge

1 reference

https://pubmed.ncbi.nlm.nih.gov/10577978

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/10577978

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor α

1 reference

https://pubmed.ncbi.nlm.nih.gov/10577978

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unraveling function in the TNF ligand and receptor families

1 reference

https://pubmed.ncbi.nlm.nih.gov/10577978

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics, immunogenicity, and efficacy of dimeric TNFR binding proteins in healthy and bacteremic baboon

1 reference

https://pubmed.ncbi.nlm.nih.gov/10577978

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Should improvement in rheumatoid arthritis clinical trials be defined as fifty percent or seventy percent improvement in core set measures, rather than twenty percent?

1 reference

https://pubmed.ncbi.nlm.nih.gov/10577978

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of pro-inflammatory cytokines in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10577978

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical trials on biologics in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10577978

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of autoimmunity by proinflammatory cytokines

1 reference

https://pubmed.ncbi.nlm.nih.gov/10577978

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution of TNF-alpha, TNF-R55 and TNF-R75 in the rheumatoid synovial membrane: TNF receptors are localized preferentially in the lining layer; TNF-alpha is distributed mainly in the vicinity of TNF receptors in the deeper layers

1 reference

https://pubmed.ncbi.nlm.nih.gov/10577978

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiarthritic activity of soluble tumor necrosis factor receptor type I forms in adjuvant arthritis: correlation of plasma levels with efficacy

1 reference

https://pubmed.ncbi.nlm.nih.gov/10577978

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble tumor necrosis factor receptors in arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/10577978

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1136/ARD.58.2008.I73

1 reference

Europe PubMed Central

29 July 2017

1 reference

Europe PubMed Central

29 July 2017

1 reference

Europe PubMed Central

29 July 2017

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