Targeted deletion of hepatocyte ABCA1 leads to very low density lipoprotein triglyceride overproduction and low density lipoprotein hypercatabolism (Q33782576)

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English	Targeted deletion of hepatocyte ABCA1 leads to very low density lipoprotein triglyceride overproduction and low density lipoprotein hypercatabolism	scientific article

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18 January 2020

Targeted deletion of hepatocyte ABCA1 leads to very low density lipoprotein triglyceride overproduction and low density lipoprotein hypercatabolism (English)

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18 January 2020

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Roshni Singaraja

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18 January 2020

Michael R. Hayden

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Michael R Hayden

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18 January 2020

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Soonkyu Chung

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18 January 2020

Jenelle M Timmins

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18 January 2020

Myngan Duong

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18 January 2020

Chiara Degirolamo

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18 January 2020

Shunxing Rong

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18 January 2020

Janet K Sawyer

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18 January 2020

Nobuyo Maeda

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18 January 2020

Lawrence L Rudel

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18 January 2020

Gregory S Shelness

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18 January 2020

John S Parks

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18 January 2020

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23 February 2010

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18 January 2020

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13

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Journal of Biological Chemistry

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18 January 2020

285

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18 January 2020

16

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18 January 2020

12197-12209

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18 January 2020

A novel role for ABCA1-generated large pre-beta migrating nascent HDL in the regulation of hepatic VLDL triglyceride secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852959

4 July 2018

ABCA1 promotes the de novo biogenesis of apolipoprotein CIII-containing HDL particles in vivo and modulates the severity of apolipoprotein CIII-induced hypertriglyceridemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852959

4 July 2018

Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852959

4 July 2018

FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852959

4 July 2018

Golgi-associated maturation of very low density lipoproteins involves conformational changes in apolipoprotein B, but is not dependent on apolipoprotein E

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852959

4 July 2018

Phosphoinositide-metabolizing enzymes at the interface between membrane traffic and cell signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852959

4 July 2018

ABCA1 overexpression in the liver of LDLr-KO mice leads to accumulation of pro-atherogenic lipoproteins and enhanced atherosclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852959

4 July 2018

Phosphatidylinositol-3,4,5-trisphosphate regulates the formation of the basolateral plasma membrane in epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852959

4 July 2018

Intestinal ABCA1 directly contributes to HDL biogenesis in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852959

4 July 2018

Evolution and mechanism of apolipoprotein B-containing lipoprotein assembly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852959

4 July 2018

Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852959

4 July 2018

ABCA1-dependent lipid efflux to apolipoprotein A-I mediates HDL particle formation and decreases VLDL secretion from murine hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852959

4 July 2018

Insulin regulates hepatic apolipoprotein B production independent of the mass or activity of Akt1/PKBalpha.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852959

4 July 2018

Postprandial hypertriglyceridaemia in patients with Tangier disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852959

4 July 2018

Alterations of plasma lipids in mice via adenoviral-mediated hepatic overexpression of human ABCA1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852959

4 July 2018

Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852959

4 July 2018

Endocytosis is enhanced in Tangier fibroblasts: possible role of ATP-binding cassette protein A1 in endosomal vesicular transport

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852959

4 July 2018

Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852959

4 July 2018

Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852959

4 July 2018

The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852959

4 July 2018

Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852959

4 July 2018

Phosphoinositide 3-kinase activity is necessary for insulin-dependent inhibition of apolipoprotein B secretion by rat hepatocytes and localizes to the endoplasmic reticulum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852959

4 July 2018

Insulin-mediated inhibition of apolipoprotein B secretion requires an intracellular trafficking event and phosphatidylinositol 3-kinase activation: studies with brefeldin A and wortmannin in primary cultures of rat hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852959

4 July 2018

Studies on the mechanism of hypertriglyceridemia in Tangier disease. Determination of plasma lipolytic activities, k1 values and apolipoprotein composition of the major lipoprotein density classes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852959

4 July 2018

Tangier disease: a disorder of intracellular membrane traffic

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852959

4 July 2018

Hydrolysis of neutral lipid substrates by rat hepatic lipase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852959

4 July 2018

ABCA1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.096933

21 January 2018

ACAT2 contributes cholesteryl esters to newly secreted VLDL, whereas LCAT adds cholesteryl ester to LDL in mice.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.096933

21 January 2018

Determining hepatic triglyceride production in mice: comparison of poloxamer 407 with Triton WR-1339.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.096933

21 January 2018

PI3-kinase activity modulates apo B available for hepatic VLDL production in apobec-1-/- mice.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.096933

21 January 2018

Both hepatic and extrahepatic ABCA1 have discrete and essential functions in the maintenance of plasma high-density lipoprotein cholesterol levels in vivo.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.096933

21 January 2018

Overproduction of VLDL1 driven by hyperglycemia is a dominant feature of diabetic dyslipidemia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.096933

21 January 2018

Insulin inhibits the maturation phase of VLDL assembly via a phosphoinositide 3-kinase-mediated event

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.096933

21 January 2018

Transport of lipids from golgi to plasma membrane is defective in tangier disease patients and Abc1-deficient mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.096933

21 January 2018

Secretory vesicular transport from the Golgi is altered during ATP-binding cassette protein A1 (ABCA1)-mediated cholesterol efflux

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.096933

21 January 2018

Cholesterol and apolipoprotein B metabolism in Tangier disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.096933

21 January 2018

Tissue-specific roles of ABCA1 influence susceptibility to atherosclerosis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.096933

21 January 2018

Homozygous Tangier disease and cardiovascular disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.096933

21 January 2018

In vivo contribution of LCAT to apolipoprotein B lipoprotein cholesteryl esters in LDL receptor and apolipoprotein E knockout mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2852959

30 October 2018

Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.096933

21 January 2018

Different kinetic fates of apolipoproteins A-I and A-II from lymph chylomicra of nonhuman primates. Effect of saturated versus polyunsaturated dietary fat

1 reference

https://pubmed.ncbi.nlm.nih.gov/20178985

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Measurement of apolipoprotein B radioactivity in whole blood plasma by precipitation with isopropanol

1 reference

https://pubmed.ncbi.nlm.nih.gov/20178985

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal processing of Golgi elements and lysosomes in Tangier disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20178985

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzymatic determination of triglyceride, free cholesterol, and total cholesterol in tissue lipid extracts

1 reference

https://pubmed.ncbi.nlm.nih.gov/20178985

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute suppression of VLDL1 secretion rate by insulin is associated with hepatic fat content and insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/20178985

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M109.096933

1 reference

Europe PubMed Central

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18 January 2020

PMC publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20178985%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20178985%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

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