Ultra-low concentrations of naloxone selectively antagonize excitatory effects of morphine on sensory neurons, thereby increasing its antinociceptive potency and attenuating tolerance/dependence during chronic cotreatment (Q33782677)

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English	Ultra-low concentrations of naloxone selectively antagonize excitatory effects of morphine on sensory neurons, thereby increasing its antinociceptive potency and attenuating tolerance/dependence during chronic cotreatment	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Ultra-low concentrations of naloxone selectively antagonize excitatory effects of morphine on sensory neurons, thereby increasing its antinociceptive potency and attenuating tolerance/dependence during chronic cotreatment (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

1 reference

based on heuristic

inferred from title

author name string

Crain SM

1

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Shen KF

2

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

language of work or name

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publication date

1 November 1995

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Europe PubMed Central

PubMed publication ID

29 July 2017

number of pages

5

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inferred from page(s)

Proceedings of the National Academy of Sciences of the United States of America

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Europe PubMed Central

PubMed publication ID

29 July 2017

92

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

23

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

10540-10544

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Antinociceptive profile of biphalin, a dimeric enkephalin analog

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Direct coupling of opioid receptors to both stimulatory and inhibitory guanine nucleotide-binding proteins in F-11 neuroblastoma-sensory neuron hybrid cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Antagonists at excitatory opioid receptors on sensory neurons in culture increase potency and specificity of opiate analgesics and attenuate development of tolerance/dependence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Diversity of agents that modify opioid tolerance, physical dependence, abstinence syndrome, and self-administrative behavior.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Dose-dependent analgesic and hyperalgesic effects of systemic naloxone in arthritic rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Endogenous opiates and nociception: a possible functional role in both pain inhibition and detection as revealed by intrathecal naloxone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

A comparison of the effects of morphine sulphate and nitrous oxide analgesia on chronic pain states in man.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Opioid peptides with differential affinity for mu and delta receptors decrease sensory neuron calcium-dependent action potentials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Possible medullary kappa hyperalgesic mechanism. I. A new potential role for endogenous opioid peptides in pain perception

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Drug interaction in the field of analgesic drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Naltrexone, an antagonist for the treatment of heroin dependence. Effects in man.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Postoperative pain relief with naloxone. Severe respiratory depression and pain after high dose buprenorphine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Method of administration determines the effect of naloxone on pain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Low doses of naloxone produce analgesia in the mouse brain by blocking presynaptic autoinhibition of enkephalin release

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Maturation of opioid sensitivity of fetal mouse dorsal root ganglion neuron perikarya in organotypic cultures: regulation by spinal cord

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Potentiation of pentazocine analgesia by low-dose naloxone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

"Paradoxical" analgesia induced by naloxone and naltrexone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Analgesia produced by low doses of the opiate antagonist naloxone in arthritic rats is reduced in morphine-tolerant animals.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Naltrexone. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in the management of opioid dependence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Behavioural evidence for a bidirectional effect of systemic naloxone in a model of experimental neuropathy in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Morphine: some puzzles of well-known substance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Enhancement of naloxone-induced analgesia by pretreatment with morphine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Dual opioid modulation of the action potential duration of mouse dorsal root ganglion neurons in culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Paradoxical analgesia produced by low doses of the opiate-antagonist naloxone is mediated by interaction at a site with characteristics of the delta opioid receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

A pharmacological overview of opioid mechanisms mediating analgesia and hyperalgesia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Cholera toxin-A subunit blocks opioid excitatory effects on sensory neuron action potentials indicating mediation by Gs-linked opioid receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Opioids can evoke direct receptor-mediated excitatory effects on sensory neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Cholera toxin-B subunit blocks excitatory effects of opioids on sensory neuron action potentials indicating that GM1 ganglioside may regulate Gs-linked opioid receptor functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Chronic selective blockade of mu opioid receptors produces analgesia and augmentation of the effects of a kappa agonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

After GM1 ganglioside treatment of sensory neurons naloxone paradoxically prolongs the action potential but still antagonizes opioid inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Brief treatment of sensory ganglion neurons with GM1 ganglioside enhances the efficacy of opioid excitatory effects on the action potential

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Somal membrane properties of physiologically identified sensory neurons in the rat: effects of nerve growth factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Chronic selective activation of excitatory opioid receptor functions in sensory neurons results in opioid 'dependence' without tolerance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

After chronic opioid exposure sensory neurons become supersensitive to the excitatory effects of opioid agonists and antagonists as occurs after acute elevation of GM1 ganglioside

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Opioid and nicotinic analgesic and hyperalgesic loci in the rat brain stem

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Reinitiation of sensitivity to naloxone by a single narcotic injection in postaddicted mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

The effects of naltrexone on the development of physical dependence on morphine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Naloxone alters pain perception and somatosensory evoked potentials in normal subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Naloxone dose dependently produces analgesia and hyperalgesia in postoperative pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Enkephalin inhibits release of substance P from sensory neurons in culture and decreases action potential duration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Inhibition by naloxone of tolerance and dependence in mice treated acutely and chronically with morphine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Responsivity to naloxone during morphine dependence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

4 July 2018

Pharmacologic characteristics of a medullary hyperalgesic center.

1 reference

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30 October 2018

Hyperalgesic and analgesic actions of morphine, U50-488, naltrexone, and (-)-lobeline in the rat brainstem.

1 reference

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30 October 2018

Nerve growth factor rapidly prolongs the action potential of mature sensory ganglion neurons in culture, and this effect requires activation of Gs-coupled excitatory kappa-opioid receptors on these cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=40647

30 October 2018

Specific N- or C-terminus modified dynorphin and beta-endorphin peptides can selectively block excitatory opioid receptor functions in sensory neurons and unmask potent inhibitory effects of opioid agonists

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30 October 2018

Analgesia produced by normal doses of opioid antagonists alone and in combination with morphine

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30 October 2018

Opioids excite rather than inhibit sensory neurons after chronic opioid exposure of spinal cord-ganglion cultures

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30 October 2018

Analgesia and hyperalgesia produced in the rat by intrathecal naloxone

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https://pubmed.ncbi.nlm.nih.gov/7479836

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simultaneous quantitative assessment of morphine tolerance and physical dependence

1 reference

https://pubmed.ncbi.nlm.nih.gov/7479836

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systemic administration of naloxone produces analgesia in BALB/c mice in the formalin pain test

1 reference

https://pubmed.ncbi.nlm.nih.gov/7479836

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low dose naloxone enhances buprenorphine in a tooth pulp antinociceptive assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/7479836

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Naloxone analgesia: an update

1 reference

https://pubmed.ncbi.nlm.nih.gov/7479836

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracerebroventricular physostigmine-induced analgesia: enhancement by naloxone, beta-funaltrexamine and nor-binaltorphimine and antagonism by dynorphin A (1-17)

1 reference

https://pubmed.ncbi.nlm.nih.gov/7479836

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Maintenance of morphine dependence by naloxone in acutely dependent mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/7479836

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibiting a spinal dynorphin A component enhances intrathecal morphine antinociception in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/7479836

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of the antianalgesic action of dynorphin A in mice by cholera toxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/7479836

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.92.23.10540

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

1995PNAS...9210540C

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

ResearchGate publication ID

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