The mechanism of the alkaline phosphatase reaction: insights from NMR, crystallography and site-specific mutagenesis (Q33783681)

29 July 2017

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title

The mechanism of the alkaline phosphatase reaction: insights from NMR, crystallography and site-specific mutagenesis (English)

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29 July 2017

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Holtz KM

1

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29 July 2017

Kantrowitz ER

series ordinal

2

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29 July 2017

language of work or name

English

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publication date

1 November 1999

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29 July 2017

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29 July 2017

volume

462

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29 July 2017

issue

1-2

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29 July 2017

page(s)

7-11

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Structural characteristics of the PHO8 gene encoding repressible alkaline phosphatase in Saccharomyces cerevisiae

29 July 2017

cites work

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Cloning, sequencing, and chromosomal localization of human term placental alkaline phosphatase cDNA

21 January 2018

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Cloning and sequencing of human intestinal alkaline phosphatase cDNA

21 January 2018

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Isolation and characterization of a cDNA encoding a human liver/bone/kidney-type alkaline phosphatase

21 January 2018

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Mutations at positions 153 and 328 in Escherichia coli alkaline phosphatase provide insight towards the structure and function of mammalian and yeast alkaline phosphatases

21 January 2018

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High-resolution (1.5 A) crystal structure of phospholipase C from Bacillus cereus

21 January 2018

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Phosphate incorporation into alkaline phosphatase of E. coli

21 January 2018

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Stereochemistry of phosphoryl group transfer using a chiral [16O, 17O, 18O] stereochemical course of alkaline phosphatase

21 January 2018

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Phosphorus-31 nuclear magnetic resonance study of alkaline phosphatase: the role of inorganic phosphate in limiting the enzyme turnover rate at alkaline pH

21 January 2018

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Reaction mechanism of alkaline phosphatase based on crystal structures. Two-metal ion catalysis

21 January 2018

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Trapping and visualization of a covalent enzyme–phosphate intermediate

21 January 2018

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A model of the transition state in the alkaline phosphatase reaction

21 January 2018

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Kinetic and X-ray structural studies of three mutant E. coli alkaline phosphatases: insights into the catalytic mechanism without the nucleophile Ser102

21 January 2018

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Dependence of the phosphorylation of alkaline phosphatase by phosphate monoesters on the pKa of the leaving group.

21 January 2018

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Use of site-directed mutagenesis to elucidate the role of arginine-166 in the catalytic mechanism of alkaline phosphatase

21 January 2018

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Alteration of aspartate 101 in the active site of Escherichia coli alkaline phosphatase enhances the catalytic activity.

21 January 2018

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3-D structure of the D153G mutant of Escherichia coli alkaline phosphatase: an enzyme with weaker magnesium binding and increased catalytic activity

21 January 2018

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Magnesium in the active site of Escherichia coli alkaline phosphatase is important for both structural stabilization and catalysis.

21 January 2018

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Mutagenesis of conserved residues within the active site of Escherichia coli alkaline phosphatase yields enzymes with increased kcat

21 January 2018

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A water-mediated salt link in the catalytic site of Escherichia coli alkaline phosphatase may influence activity.

21 January 2018

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Effect of magnesium on the properties of zinc alkaline phosphatase

21 January 2018

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Role of magnesium in Escherichia coli alkaline phosphatase

21 January 2018

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Kinetic and structural consequences of replacing the aspartate bridge by asparagine in the catalytic metal triad of Escherichia coli alkaline phosphatase

21 January 2018

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SETOR: hardware-lighted three-dimensional solid model representations of macromolecules

21 January 2018

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Alkaline phosphatase is an almost perfect enzyme

21 January 2018

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Structure of alkaline phosphatases

21 January 2018

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THE FREE ENERGY OF HYDROLYSIS OF PHOSPHORYL-PHOSPHATASE

21 January 2018

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https://api.crossref.org/works/10.1016%2FS0014-5793%2899%2901448-9

Function of arginine-166 in the active site of Escherichia coli alkaline phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2899%2901448-9

3-D structure of a mutant (Asp101-->Ser) of E.coli alkaline phosphatase with higher catalytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2899%2901448-9

Rate-determining step of Escherichia coli alkaline phosphatase altered by the removal of a positive charge at the active center

21 January 2018

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https://api.crossref.org/works/10.1016%2FS0014-5793%2899%2901448-9

10.1016/S0014-5793(99)01448-9

21 January 2018

Identifiers

DOI

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29 July 2017

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