Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity (Q33794968)

29 July 2017

Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity (English)

1 reference

29 July 2017

Rebecca A Stockton

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29 July 2017

Robert Shenkar

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2

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29 July 2017

Issam A Awad

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3

1 reference

29 July 2017

Mark H Ginsberg

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4

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29 July 2017

language of work or name

English

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publication date

22 March 2010

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Journal of Experimental Medicine

29 July 2017

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29 July 2017

207

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29 July 2017

4

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29 July 2017

881-896

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Cerebral cavernous malformation 2 protein promotes smad ubiquitin regulatory factor 1-mediated RhoA degradation in endothelial cells

29 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

Immune response in human cerebral cavernous malformations

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

Tissue-specific conditional CCM2 knockout mice establish the essential role of endothelial CCM2 in angiogenesis: implications for human cerebral cavernous malformations

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

A two-hit mechanism causes cerebral cavernous malformations: complete inactivation of CCM1, CCM2 or CCM3 in affected endothelial cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

Biallelic somatic and germline mutations in cerebral cavernous malformations (CCMs): evidence for a two-hit mechanism of CCM pathogenesis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

Advanced magnetic resonance imaging of cerebral cavernous malformations: part II. Imaging of lesions in murine models

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

Advanced magnetic resonance imaging of cerebral cavernous malformations: part I. High-field imaging of excised human lesions

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

Hemorrhage from cavernous malformations of the brain: definition and reporting standards. Angioma Alliance Scientific Advisory Board

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

Smooth muscle cell calcium activation mechanisms

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

Applications for ROCK kinase inhibition

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

Multiple cerebral cavernous malformations associated with extracranial mesenchymal anomalies

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

Laser-scanning velocimetry: a confocal microscopy method for quantitative measurement of cardiovascular performance in zebrafish embryos and larvae

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

Highly variable penetrance in subjects affected with cavernous cerebral angiomas (CCM) carrying novel CCM1 and CCM2 mutations.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

Induction of vascular permeability: beta PIX and GIT1 scaffold the activation of extracellular signal-regulated kinase by PAK.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

Mouse preimplantation embryo responses to culture medium osmolarity include increased expression of CCM2 and p38 MAPK activation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

Deletions in CCM2 are a common cause of cerebral cavernous malformations

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

Rho kinases in cardiovascular physiology and pathophysiology

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

Genetics of cerebral cavernous malformations

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

Rho-kinase is an important therapeutic target in cardiovascular medicine

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

28 July 2018

Rho and vascular disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

Radiation-induced cavernomas of the brain

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

Loss of p53 sensitizes mice with a mutation in Ccm1 (KRIT1) to development of cerebral vascular malformations.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

p21-activated kinase regulates endothelial permeability through modulation of contractility.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

Pathobiology of human cerebrovascular malformations: basic mechanisms and clinical relevance

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

Intracellular signalling involved in modulating human endothelial barrier function

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

Cytoskeletal regulation of pulmonary vascular permeability

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

Ultrastructural and immunocytochemical evidence that an incompetent blood-brain barrier is related to the pathophysiology of cavernous malformations

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

Association of Krev-1/rap1a with Krit1, a novel ankyrin repeat-containing protein encoded by a gene mapping to 7q21-22

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

Proteomic identification of the cerebral cavernous malformation signaling complex

28 July 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20091258

ccm1 cell autonomously regulates endothelial cellular morphogenesis and vascular tubulogenesis in zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20091258

Mutations in a gene encoding a novel protein containing a phosphotyrosine-binding domain cause type 2 cerebral cavernous malformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20091258

santa and valentine pattern concentric growth of cardiac myocardium in the zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20091258

Activation of Rho kinase isoforms in lung endothelial cells during inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20091258

Patterns of expression of the three cerebral cavernous malformation (CCM) genes during embryonic and postnatal brain development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20091258

Neuronal expression of the Ccm2 gene in a new mouse model of cerebral cavernous malformations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20091258

Blocking p21-activated kinase reduces lipopolysaccharide-induced acute lung injury by preventing polymorphonuclear leukocyte infiltration

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20091258

Mutations in the gene encoding KRIT1, a Krev-1/rap1a binding protein, cause cerebral cavernous malformations (CCM1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20091258

Amelioration of endothelial damage/dysfunction is a possible mechanism for the neuroprotective effects of Rho-kinase inhibitors against ischemic brain damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20091258

CCM2 expression parallels that of CCM1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20091258

Rho and ROCK signaling in VEGF-induced microvascular endothelial hyperpermeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20091258

An essential role for Rac1 in endothelial cell function and vascular development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20091258

Ccm1 is required for arterial morphogenesis: implications for the etiology of human cavernous malformations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20091258

Rap1 GTPase inhibits leukocyte transmigration by promoting endothelial barrier function

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20091258

Rac and Rho play opposing roles in the regulation of hypoxia/reoxygenation-induced permeability changes in pulmonary artery endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20091258

Fasudil, a Rho kinase (ROCK) inhibitor, protects against ischemic neuronal damage in vitro and in vivo by acting directly on neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20091258

CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20091258

Interaction between krit1 and malcavernin: implications for the pathogenesis of cerebral cavernous malformations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20091258

Central role of rho kinase in lipopolysaccharide-induced platelet capture on venous endothelium

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

Reactive oxygen species mediate Rac-induced loss of cell-cell adhesion in primary human endothelial cells

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

Rho and Rac but not Cdc42 regulate endothelial cell permeability.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856024

Hyperosmotic induction of mitogen-activated protein kinase scaffolding

30 October 2018

1 reference

12 December 2020

Unfolding knowledge on cerebral cavernous malformations

1 reference

12 December 2020

Epac1 regulates integrity of endothelial cell junctions through VE-cadherin

1 reference

12 December 2020

Attenuating burn wound inflammatory signaling reduces systemic inflammation and acute lung injury

1 reference

12 December 2020

Spectrum of genotype and clinical manifestations in cerebral cavernous malformations

1 reference

12 December 2020

Pathological considerations to irradiation of cavernous malformations

1 reference

12 December 2020

Oligoclonal immune response in cerebral cavernous malformations. Laboratory investigation

1 reference

12 December 2020

Differential roles of p55 and p75 tumor necrosis factor receptors on stretch-induced pulmonary edema in mice

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20091258

1 reference

29 July 2017

1 reference

29 July 2017

1 reference