Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling (Q33799288)

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English	Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling	scientific article

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scholarly article

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Europe PubMed Central

29 July 2017

Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling (English)

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Europe PubMed Central

29 July 2017

8

object named as

Andrej Sali

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author name string

Matthias B Wittwer

1

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Europe PubMed Central

29 July 2017

Arik A Zur

2

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Europe PubMed Central

29 July 2017

Natalia Khuri

3

1 reference

Europe PubMed Central

29 July 2017

Yasuto Kido

4

1 reference

Europe PubMed Central

29 July 2017

Alan Kosaka

5

1 reference

Europe PubMed Central

29 July 2017

Xuexiang Zhang

6

1 reference

Europe PubMed Central

29 July 2017

Kari M Morrissey

7

1 reference

Europe PubMed Central

29 July 2017

Yong Huang

9

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Europe PubMed Central

29 July 2017

Kathleen M Giacomini

10

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Europe PubMed Central

29 July 2017

language of work or name

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publication date

22 January 2013

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Europe PubMed Central

29 July 2017

Journal of Medicinal Chemistry

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Europe PubMed Central

29 July 2017

56

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29 July 2017

3

1 reference

Europe PubMed Central

29 July 2017

781-795

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Europe PubMed Central

29 July 2017

Twelve transmembrane helices form the functional core of mammalian MATE1 (multidrug and toxin extruder 1) protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

Molecular determinants of ligand selectivity for the human multidrug and toxin extruder proteins MATE1 and MATE2-K.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

Proton pump inhibitors inhibit metformin uptake by organic cation transporters (OCTs)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

Characterization of the human MATE2 proton-coupled polyspecific organic cation exporter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

Interactions of tyrosine kinase inhibitors with organic cation transporters and multidrug and toxic compound extrusion proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

DrugBank 3.0: a comprehensive resource for 'omics' research on drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

Double-transfected MDCK cells expressing human OCT1/MATE1 or OCT2/MATE1: determinants of uptake and transcellular translocation of organic cations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

Structure of a cation-bound multidrug and toxic compound extrusion transporter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

Organic cation transporters modulate the uptake and cytotoxicity of picoplatin, a third-generation platinum analogue.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

Transporter studies with the 3-O-sulfate conjugate of 17alpha-ethinylestradiol: assessment of human kidney drug transporters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

Therapeutic implications of renal anionic drug transporters.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

Membrane transporters in drug development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

Maraviroc: pharmacokinetics and drug interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

Involvement of human multidrug and toxin extrusion 1 in the drug interaction between cimetidine and metformin in renal epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

The inhibition of human multidrug and toxin extrusion 1 is involved in the drug-drug interaction caused by cimetidine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

Transcellular transport of organic cations in double-transfected MDCK cells expressing human organic cation transporters hOCT1/hMATE1 and hOCT2/hMATE1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

Assessment of the absorption, metabolism and absolute bioavailability of maraviroc in healthy male subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

DrugBank: a knowledgebase for drugs, drug actions and drug targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

Organic cation transporters are determinants of oxaliplatin cytotoxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

DrugBank: a comprehensive resource for in silico drug discovery and exploration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

A human transporter protein that mediates the final excretion step for toxic organic cations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

Effect of St John's wort on imatinib mesylate pharmacokinetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

Transport of organic anions across the basolateral membrane of proximal tubule cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

Influence of substrate structure on turnover of the organic cation/H+ exchanger of the renal luminal membrane.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

Factors affecting the differentiation of epithelial transport and responsiveness to hormones

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

Contraluminal transport of organic cations in the proximal tubule of the rat kidney. I. Kinetics of N1-methylnicotinamide and tetraethylammonium, influence of K+, HCO3-, pH; inhibition by aliphatic primary, secondary and tertiary amines and mono- an

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

4 July 2018

Comparison of different approaches to define the applicability domain of QSAR models.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

30 October 2018

Screening of OATP1B1/3 and OCT1 inhibitors in cryopreserved hepatocytes in suspension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

30 October 2018

Targeted disruption of the multidrug and toxin extrusion 1 (mate1) gene in mice reduces renal secretion of metformin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

30 October 2018

Pharmacokinetics and effect on caffeine metabolism of the proton pump inhibitors, omeprazole, lansoprazole, and pantoprazole

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4068829

30 October 2018

Predicting the Predictability: A Unified Approach to the Applicability Domain Problem of QSAR Models

1 reference

https://pubmed.ncbi.nlm.nih.gov/23241029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure and interaction of inhibitors with the TEA/H+ exchanger of rabbit renal brush border membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23241029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contraluminal transport of organic cations in the proximal tubule of the rat kidney. II. Specificity: anilines, phenylalkylamines (catecholamines), heterocyclic compounds (pyridines, quinolines, acridines)

1 reference

https://pubmed.ncbi.nlm.nih.gov/23241029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of a MATE protein inhibitor, pyrimethamine, on the renal elimination of metformin at oral microdose and at therapeutic dose in healthy subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/23241029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of substrate structure on substrate binding to the renal organic cation/H+ exchanger

1 reference

https://pubmed.ncbi.nlm.nih.gov/23241029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Luminal transport system for choline+ in relation to the other organic cation transport systems in the rat proximal tubule. Kinetics, specificity: alkyl/arylamines, alkylamines with OH, O, SH, NH2, ROCO, RSCO and H2PO4-groups, methylaminostyryl, rho

1 reference

https://pubmed.ncbi.nlm.nih.gov/23241029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Porous-bottom dishes for culture of polarized cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23241029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Competitive Inhibition of the Luminal Efflux by Multidrug and Toxin Extrusions, but Not Basolateral Uptake by Organic Cation Transporter 2, Is the Likely Mechanism Underlying the Pharmacokinetic Drug-Drug Interactions Caused by Cimetidine in the Kidn

1 reference

https://pubmed.ncbi.nlm.nih.gov/23241029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Luminal transport system for H+/organic cations in the rat proximal tubule. Kinetics, dependence on pH; specificity as compared with the contraluminal organic cation-transport system

1 reference

https://pubmed.ncbi.nlm.nih.gov/23241029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Stepwise Approach for Defining the Applicability Domain of SAR and QSAR Models

1 reference

https://pubmed.ncbi.nlm.nih.gov/23241029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three useful dimensions for domain applicability in QSAR models using random forest

1 reference

https://pubmed.ncbi.nlm.nih.gov/23241029

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM301302S

1 reference

Europe PubMed Central

29 July 2017

release_5ptydb42fbfj3e5kunqbbhzdli

1 reference

https://api.fatcat.wiki/v0/release/5ptydb42fbfj3e5kunqbbhzdli

24 November 2022

based on heuristic

mapped directly with Wikidata item

1 reference

Europe PubMed Central

29 July 2017

1 reference

Europe PubMed Central

29 July 2017

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