Valproic acid sensitizes pancreatic cancer cells to natural killer cell-mediated lysis by upregulating MICA and MICB via the PI3K/Akt signaling pathway (Q33825014)

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English	Valproic acid sensitizes pancreatic cancer cells to natural killer cell-mediated lysis by upregulating MICA and MICB via the PI3K/Akt signaling pathway	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

29 July 2017

Valproic acid sensitizes pancreatic cancer cells to natural killer cell-mediated lysis by upregulating MICA and MICB via the PI3K/Akt signaling pathway (English)

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Europe PubMed Central

PubMed publication ID

29 July 2017

pancreatic cancer

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based on heuristic

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author name string

Pengfei Shi

1

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Europe PubMed Central

PubMed publication ID

29 July 2017

Tao Yin

2

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Europe PubMed Central

PubMed publication ID

29 July 2017

Feng Zhou

3

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Europe PubMed Central

PubMed publication ID

29 July 2017

Pengfei Cui

4

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Europe PubMed Central

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29 July 2017

Shanmiao Gou

5

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Europe PubMed Central

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29 July 2017

Chunyou Wang

6

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29 July 2017

language of work or name

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publication date

25 May 2014

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Europe PubMed Central

PubMed publication ID

29 July 2017

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Europe PubMed Central

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29 July 2017

14

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Europe PubMed Central

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29 July 2017

370

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Europe PubMed Central

PubMed publication ID

29 July 2017

Akt1 enhances CA916798 expression through mTOR pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076062

4 July 2018

Valproic acid upregulates NKG2D ligand expression through an ERK-dependent mechanism and potentially enhances NK cell-mediated lysis of myeloma

1 reference

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4 July 2018

Chimeric NKG2D CAR-expressing T cell-mediated attack of human ovarian cancer is enhanced by histone deacetylase inhibition

1 reference

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4 July 2018

Ursolic acid inhibits growth and induces apoptosis in gemcitabine-resistant human pancreatic cancer via the JNK and PI3K/Akt/NF-κB pathways

1 reference

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4 July 2018

Melanoma cells become resistant to NK-cell-mediated killing when exposed to NK-cell numbers compatible with NK-cell infiltration in the tumor.

1 reference

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Engineering lymph node homing of ex vivo-expanded human natural killer cells via trogocytosis of the chemokine receptor CCR7.

1 reference

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Retracted: 3, 3'-Diindolylmethane Exhibits Antileukemic Activity In Vitro and In Vivo through a Akt-Dependent Process

1 reference

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HER2/HER3 signaling regulates NK cell-mediated cytotoxicity via MHC class I chain-related molecule A and B expression in human breast cancer cell lines

1 reference

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Human ovarian tumor cells escape γδ T cell recognition partly by down regulating surface expression of MICA and limiting cell cycle related molecules

1 reference

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Body mass index, abdominal fatness and pancreatic cancer risk: a systematic review and non-linear dose-response meta-analysis of prospective studies

1 reference

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Global cancer statistics

1 reference

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Induction of a CD8+ T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valproate in patients with acute myeloid leukemia and myelodysplasia

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p21 Downregulation is an important component of PAX3/FKHR oncogenicity and its reactivation by HDAC inhibitors enhances combination treatment.

1 reference

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Radiosensitization of epidermal growth factor receptor/HER2-positive pancreatic cancer is mediated by inhibition of Akt independent of ras mutational status

1 reference

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Hydroxyurea upregulates NKG2D ligand expression in myeloid leukemia cells synergistically with valproic acid and potentially enhances susceptibility of leukemic cells to natural killer cell-mediated cytolysis

1 reference

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Targeting PI3K signalling in cancer: opportunities, challenges and limitations

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HDAC2 mediates therapeutic resistance of pancreatic cancer cells via the BH3-only protein NOXA.

1 reference

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ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype

1 reference

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Decreased Dicer expression elicits DNA damage and up-regulation of MICA and MICB.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076062

4 July 2018

Regulation of the expression of MHC class I-related chain A, B (MICA, MICB) via chromatin remodeling and its impact on the susceptibility of leukemic cells to the cytotoxicity of NKG2D-expressing cells

1 reference

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Valproic acid induces p21 and topoisomerase-II (alpha/beta) expression and synergistically enhances etoposide cytotoxicity in human glioblastoma cell lines

1 reference

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4 July 2018

Valproic acid inhibits adhesion of vincristine- and cisplatin-resistant neuroblastoma tumour cells to endothelium

1 reference

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Cytokine-driven regulation of NK cell functions in tumor immunity: role of the MICA-NKG2D system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4076062

4 July 2018

TGF-beta and metalloproteinases differentially suppress NKG2D ligand surface expression on malignant glioma cells

1 reference

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In vivo synergy between topoisomerase II and histone deacetylase inhibitors: predictive correlates

1 reference

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Oncogenic PI3K deregulates transcription and translation

1 reference

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The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor

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Unravelling natural killer cell function: triggering and inhibitory human NK receptors

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Anti-tumor mechanisms of valproate: a novel role for an old drug

1 reference

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Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

1 reference

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Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA

1 reference

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4 July 2018

Hypoxia increases tumor cell shedding of MHC class I chain-related molecule: role of nitric oxide

1 reference

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21 January 2018

Adenomatous polyposis coli determines sensitivity to histone deacetylase inhibitor-induced apoptosis in colon cancer cells.

1 reference

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21 January 2018

Effective in vivo induction of NKG2D ligands in acute myeloid leukaemias by all-trans-retinoic acid or sodium valproate

1 reference

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21 January 2018

Natural killer cell-mediated lysis of hepatoma cells via specific induction of NKG2D ligands by the histone deacetylase inhibitor sodium valproate

1 reference

https://api.crossref.org/works/10.1186%2F1471-2407-14-370

21 January 2018

Clinical significance of the immunostimulatory MHC class I chain-related molecule A and NKG2D receptor on NK cells in pancreatic cancer

1 reference

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1 reference

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Histone deacetylase inhibition by valproic acid down-regulates c-FLIP/CASH and sensitizes hepatoma cells towards CD95- and TRAIL receptor-mediated apoptosis and chemotherapy.

1 reference

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Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATR-dependent mechanism and become susceptible to autologous NK- cell lysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24885711

12 December 2020

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10.1186/1471-2407-14-370

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Europe PubMed Central

PubMed publication ID

29 July 2017

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Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

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Europe PubMed Central

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29 July 2017

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