Substance P antagonists: the next breakthrough in treating depression? (Q33826480)

29 July 2017

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title

Substance P antagonists: the next breakthrough in treating depression? (English)

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29 July 2017

Baby S

1

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29 July 2017

Nguyen M

series ordinal

2

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29 July 2017

Tran D

series ordinal

3

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29 July 2017

Raffa RB

series ordinal

4

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29 July 2017

publication date

1 December 1999

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Journal of Clinical Pharmacy and Therapeutics

29 July 2017

published in

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29 July 2017

volume

24

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29 July 2017

issue

6

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29 July 2017

page(s)

461-469

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Distinct mechanism for antidepressant activity by blockade of central substance P receptors

29 July 2017

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Drug treatment of depression in the 1990s. An overview of achievements and future possibilities

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New antidepressant drugs and the treatment of depression in the medically ill patient

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Possible role(s) of neurokinins in CNS development and neurodegenerative or other disorders.

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Regional distribution of substance P, neurokinin alpha and neurokinin beta in rat spinal cord, nerve roots and dorsal root ganglia, and the effects of dorsal root section or spinal transection

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Distribution of cells containing mRNAs encoding substance P and neurokinin B in the rat central nervous system.

21 January 2018

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Human substance P receptor (NK-1): organization of the gene, chromosome localization, and functional expression of cDNA clones

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Isolation and characterisation of the human lung NK-1 receptor cDNA

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Molecular cloning, structural characterization and functional expression of the human substance P receptor

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Molecular characterisation, expression and localisation of human neurokinin‐3 receptor

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cDNA sequence and heterologous expression of the human neurokinin-3 receptor

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The primary structure and gene organization of human substance P and neuromedin K receptors

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Nonpeptide antagonists herald new era in tachykinin research

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The discovery of (2S,3S)-cis-2-(diphenylmethyl)-N-[(2-methoxyphenyl)methyl]-1- azabicyclo[2.2.2]-octan-3-amine as a novel, nonpeptide substance P antagonisst

21 January 2018

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Activity and Distribution of Binding Sites in Brain of a Nonpeptide Substance P (NK 1 ) Receptor Antagonist

21 January 2018

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Role of muscarinic receptor subtypes in central antinociception

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A potent and selective non-peptide antagonist of the neurokinin a (NK2) receptor

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SR 142801, the first potent non-peptide antagonist of the tachykinin NK3 receptor

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Perturbation of Rat Brain Serotonergic Systems Results in an Inverse Relation Between Substance P and Serotonin Concentrations Measured in Discrete Nuclei

21 January 2018

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Serotonin and substance P coexist in neurons of the rat's central nervous system

21 January 2018

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Immunohistochemical evidence of substance P-like immunoreactivity in some 5-hydroxytryptamine-containing neurons in the rat central nervous system

21 January 2018

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Monoaminergic modulation of the sensitivity of neurones in the cingulate cortex to iontophoretically applied substance P

21 January 2018

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Increased levels of substance P and cholecystokinin in rat cerebral cortex following repeated electroconvulsive shock and subchronic treatment with a serotonin uptake inhibitor

21 January 2018

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CSF substance P immunoreactivity in affective disorders

21 January 2018

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Fluoxetine treatment of depression. Clinical effects, drug concentrations and monoamine metabolites and N-terminally extended substance P in cerebrospinal fluid.

21 January 2018

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Evidence that substance P is utilized in medial amygdaloid facilitation of defensive rage behavior in the cat.

21 January 2018

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Structural optimization affording 2-(R)-(1-(R)-3, 5-bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a potent, orally active, long-acting morpholine acetal human NK-1 receptor antagonist

21 January 2018

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Reward for persistence in substance P research

21 January 2018

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PSYCHOPHARMACOLOGY:Can the Placebo Be the Cure?

21 January 2018

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10.1046/J.1365-2710.1999.00257.X

21 January 2018

Identifiers

DOI

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29 July 2017

1 reference