Antisense therapeutics: is it as simple as complementary base recognition? (Q33826614)

29 July 2017

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title

Antisense therapeutics: is it as simple as complementary base recognition? (English)

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29 July 2017

Agrawal S

1

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PubMed ID

10652480

29 July 2017

Kandimalla ER

series ordinal

2

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29 July 2017

1 February 2000

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Trends in Molecular Medicine

29 July 2017

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29 July 2017

6

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29 July 2017

2

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29 July 2017

72-81

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Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide

29 July 2017

1 reference

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Antisense therapeutics

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Vitravene--another piece in the mosaic

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Keeping the biotechnology of antisense in context.

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A sense phosphorothioate oligonucleotide directed to the initiation codon of transcription factor NF-kappa B p65 causes sequence-specific immune stimulation.

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Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage

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Ubiquitous induction of p53 in tumor cells by antisense inhibition of MDM2 expression.

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Characterization of a potent and specific class of antisense oligonucleotide inhibitor of human protein kinase C-alpha expression

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Growth inhibition of human pancreatic cancer cell lines by anti-sense oligonucleotides specific to mutated K-ras genes

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Antisense oligonucleotide blockade of connexin expression during embryonic bone formation: evidence of functional compensation within a multigene family

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Oligonucleotide sequences required for natural killer cell activation

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Immune stimulation by an antisense oligomer complementary to the rev gene of HIV-1

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CpG motifs in bacterial DNA trigger direct B-cell activation

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Effect of different chemically modified oligodeoxynucleotides on immune stimulation

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CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma

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Pattern and kinetics of cytokine production following administration of phosphorothioate oligonucleotides in mice

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Dual blockade of cyclic AMP response element- (CRE) and AP-1-directed transcription by CRE-transcription factor decoy oligonucleotide. gene-specific inhibition of tumor growth

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Application of transcription factor "decoy" strategy as means of gene therapy and study of gene expression in cardiovascular disease

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Selection of single-stranded DNA molecules that bind and inhibit human thrombin

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Malaria merozoite surface protein antisense oligodeoxynucleotides lack antisense activity but function as polyanions to inhibit red cell invasion

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Oligodeoxynucleotides enhance lipopolysaccharide-stimulated synthesis of tumor necrosis factor: dependence on phosphorothioate modification and reversal by heparin.

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Theoretical design of antisense RNA structures substantially improves annealing kinetics and efficacy in human cells

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Prediction of antisense oligonucleotide efficacy by in vitro methods

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Tetranucleotide GGGA motif in primary RNA transcripts. Novel target site for antisense design

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Single-stranded DNA and RNA targeted triplex-formation: UV, CD and molecular modeling studies of foldback triplexes containing different RNA, 2'-OMe-RNA and DNA strand combinations

1 reference

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The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes

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7 January 2021

In vivo pharmacokinetics of phosphorothioate oligonucleotides containing contiguous guanosines

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7 January 2021

Effects of synthetic oligonucleotides on human complement and coagulation

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Effects of phosphorothioate oligodeoxyribonucleotide and oligoribonucleotides on human complement and coagulation

1 reference

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7 January 2021

In vivo stability, disposition and metabolism of a "hybrid" oligonucleotide phosphorothioate in rats

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Mixed-backbone oligonucleotides as second generation antisense oligonucleotides: in vitro and in vivo studies

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Effect of aspirin on protein binding and tissue disposition of oligonucleotide phosphorothioate in rats

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Toxicologic effects of an oligodeoxynucleotide phosphorothioate and its analogs following intravenous administration in rats

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7 January 2021

Mixed backbone oligonucleotides: improvement in oligonucleotide-induced toxicity in vivo

1 reference

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7 January 2021

Absorption, tissue distribution and in vivo stability in rats of a hybrid antisense oligonucleotide following oral administration

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7 January 2021

On the quality control of antisense oligonucleotides

1 reference

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7 January 2021

Phosphorothioate oligodeoxynucleotides bind to basic fibroblast growth factor, inhibit its binding to cell surface receptors, and remove it from low affinity binding sites on extracellular matrix

1 reference

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7 January 2021

Characterization of Binding Sites, Extent of Binding, and Drug Interactions of Oligonucleotides with Albumin

1 reference

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7 January 2021

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Identifiers

DOI

1 reference

29 July 2017

1 reference

PubMed ID

10652480