Tyrosine kinase inhibitors in preclinical development (Q33832624)

29 July 2017

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title

Tyrosine kinase inhibitors in preclinical development (English)

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29 July 2017

Levitt ML

1

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PubMed ID

10665475

29 July 2017

Koty PP

series ordinal

2

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29 July 2017

1 January 1999

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Investigational New Drugs

29 July 2017

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29 July 2017

17

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29 July 2017

3

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29 July 2017

213-226

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https://scigraph.springernature.com/pub.10.1023/a:1006372102543

29 July 2017

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12 December 2020

A tyrosine-specific protein kinase inhibitor, alpha-cyano-3-ethoxy-4-hydroxy-5-phenylthiomethylcinnamamide, blocks the phosphorylation of tyrosine kinase substrate in intact cells.

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12 December 2020

Cytokine signaling through nonreceptor protein tyrosine kinases

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12 December 2020

Dysregulation of epidermal growth factor receptor expression in premalignant lesions during head and neck tumorigenesis

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12 December 2020

Tyrphostins. 3. Structure-activity relationship studies of alpha-substituted benzylidenemalononitrile 5-S-aryltyrphostins

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12 December 2020

Increase in activity and level of pp60c-src in progressive stages of human colorectal cancer

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12 December 2020

Cytokine receptor signalling

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12 December 2020

Modulation of methotrexate resistance by genistein in murine leukemia L1210 cells.

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12 December 2020

Synthesis and biochemical evaluation of a series of aminoflavones as potential inhibitors of protein-tyrosine kinases p56lck, EGFr, and p60v-src

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12 December 2020

Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors

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12 December 2020

Isoflavone genistein inhibits the initiation and promotion of two-stage skin carcinogenesis in mice

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12 December 2020

Transcriptional regulation by extracellular signals: mechanisms and specificity

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12 December 2020

Induction of apoptosis and inhibition of small cell lung cancer growth by the quinoxaline tyrphostins

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12 December 2020

Selective inhibition of the epidermal growth factor and HER2/neu receptors by tyrphostins

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12 December 2020

Genistein, a specific inhibitor of tyrosine-specific protein kinases

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12 December 2020

Cytotoxic activity of epidermal growth factor-genistein against breast cancer cells

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12 December 2020

Inhibition of human bladder cancer cell motility by genistein is dependent on epidermal growth factor receptor but not p21ras gene expression

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12 December 2020

Suppression of adhesion-induced protein tyrosine phosphorylation decreases invasive and metastatic potentials of B16-BL6 melanoma cells by protein tyrosine kinase inhibitor genistein

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12 December 2020

Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

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12 December 2020

Angiogenesis in cancer, vascular, rheumatoid and other disease

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12 December 2020

Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors

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12 December 2020

Autophosphorylation: a salient feature of protein kinases

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12 December 2020

Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling

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12 December 2020

Cytokine signal transduction

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12 December 2020

Induction of hydrogen peroxide production and Bax expression by caspase-3(-like) proteases in tyrosine kinase inhibitor-induced apoptosis in human small cell lung carcinoma cells.

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12 December 2020

Coexpression of platelet-derived growth factor (PDGF) and PDGF-receptor genes by primary human astrocytomas may contribute to their development and maintenance

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12 December 2020

Hematopoietic receptor complexes

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12 December 2020

Lck associates with and is activated by Kit in a small cell lung cancer cell line: inhibition of SCF-mediated growth by the Src family kinase inhibitor PP1.

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12 December 2020

A transmissible feline fibrosarcoma of viral origin

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12 December 2020

Protein tyrosine phosphatase roles in the regulation of lymphocyte signaling

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12 December 2020

Synthesis and antiproliferative activity of tyrphostins containing quinoline moieties.

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12 December 2020

Signal transduction by receptors with tyrosine kinase activity

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12 December 2020

Tyrosine kinase inhibition: an approach to drug development

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12 December 2020

Heterodimerization of the erbB-1 and erbB-2 receptors in human breast carcinoma cells: a mechanism for receptor transregulation

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12 December 2020

Growth factor signaling by receptor tyrosine kinases

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12 December 2020

Random mutagenesis of CSF-1 receptor (FMS) reveals multiple sites for activating mutations within the extracellular domain

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12 December 2020

Expression of EGF, TGF-alpha and EGFR in squamous cell lung carcinomas

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12 December 2020

Tyrosine kinase receptor-activated signal transduction pathways which lead to oncogenesis.

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12 December 2020

Tyrosine kinase activity and transformation potency of bcr-abl oncogene products.

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12 December 2020

EGF-dependent and independent programmed cell death pathways in NCI-H596 nonsmall cell lung cancer cells

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12 December 2020

Signal-transduction therapy. A novel approach to disease management

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12 December 2020

Activation of the c-abl oncogene by viral transduction or chromosomal translocation generates altered c-abl proteins with similar in vitro kinase properties

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12 December 2020

Structural organization of the bcr gene and its role in the Ph' translocation

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12 December 2020

Effects of herbimycin derivatives on src oncogene function in relation to antitumor activity

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12 December 2020

New EGF-R selective tyrosine kinase inhibitor reveals variable growth responses in prostate carcinoma cell lines PC-3 and DU-145.

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12 December 2020

Intermolecular association of the p185neu protein and EGF receptor modulates EGF receptor function

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12 December 2020

Tyrphostins: tyrosine kinase blockers as novel antiproliferative agents and dissectors of signal transduction

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12 December 2020

In vivo toxicity, pharmacokinetics, and anticancer activity of Genistein linked to recombinant human epidermal growth factor.

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12 December 2020

RETRACTED: Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class

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12 December 2020

Molecular and biochemical bases for activation of the transforming potential of the proto-oncogene c-ros

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12 December 2020

Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation

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12 December 2020

Mechanisms of action of the soy isoflavone genistein: emerging role for its effects via transforming growth factor beta signaling pathways

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12 December 2020

Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors

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12 December 2020

4-(Phenylamino)pyrrolopyrimidines: potent and selective, ATP site directed inhibitors of the EGF-receptor protein tyrosine kinase

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12 December 2020

A point mutation in the neu oncogene mimics ligand induction of receptor aggregation

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12 December 2020

Flk-1 as a target for tumor growth inhibition.

1 reference

12 December 2020

The role of metabolism in mammary epithelial cell growth inhibition by the isoflavones genistein and biochanin A.

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12 December 2020

Effects of the tyrosine-kinase inhibitor geldanamycin on ligand-induced Her-2/neu activation, receptor expression and proliferation of Her-2-positive malignant cell lines

1 reference

12 December 2020

Cell cycle-independent death of prostate adenocarcinoma is induced by the trk tyrosine kinase inhibitor CEP-751 (KT6587)

1 reference

12 December 2020

Dimerization of cell surface receptors in signal transduction

1 reference

12 December 2020

Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

1 reference

12 December 2020

Tyrosine kinase inhibitors, emodin and its derivative repress HER-2/neu-induced cellular transformation and metastasis-associated properties.

1 reference

12 December 2020

Sensitization of HER-2/neu-overexpressing non-small cell lung cancer cells to chemotherapeutic drugs by tyrosine kinase inhibitor emodin

1 reference

12 December 2020

Skin cancer chemopreventive effects of a flavonoid antioxidant silymarin are mediated via impairment of receptor tyrosine kinase signaling and perturbation in cell cycle progression.

1 reference

12 December 2020

Epidermal growth factor receptor tyrosine kinase inhibitors as potential cancer chemopreventives.

1 reference

12 December 2020

Inhibition of growth of primary human tumour cell cultures by a 4-anilinoquinazoline inhibitor of the epidermal growth factor receptor family of tyrosine kinases

1 reference

12 December 2020

Multichain immune recognition receptors: similarities in structure and signaling pathways

1 reference

12 December 2020

Prolactin-mediated gene activation in mammary epithelial cells

1 reference

12 December 2020

The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene

1 reference

12 December 2020

Tissue-specific transformation by epidermal growth factor receptor: a single point mutation within the ATP-binding pocket of the erbB product increases its intrinsic kinase activity and activates its sarcomagenic potential

1 reference

12 December 2020

Oncogenic activation of the neu-encoded receptor protein by point mutation and deletion

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12 December 2020

Non-receptor protein tyrosine kinases as immune targets of viruses

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12 December 2020

Cell differentiation and cell-cycle alterations by tyrosine kinase inhibitors in human melanoma cells

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12 December 2020

Molecular mechanism of growth hormone action

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12 December 2020

Chromosome studies on normal and leukemic human leukocytes

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12 December 2020

Quercetin in our diet: from potent mutagen to probable anticarcinogen

1 reference

12 December 2020

Chemosensitization of glioblastoma cells to bis-dichloroethyl-nitrosourea with tyrphostin AG17.

1 reference

12 December 2020

Protein-tyrosine kinase inhibition: mechanism-based discovery of antitumor agents

1 reference

12 December 2020

Tyrosine kinase inhibitors. 10. Isomeric 4-[(3-bromophenyl)amino]pyrido[d]-pyrimidines are potent ATP binding site inhibitors of the tyrosine kinase function of the epidermal growth factor receptor

1 reference

12 December 2020

Tyrphostin 4-nitrobenzylidene malononitrile reduces chemotherapy toxicity without impairing efficacy

1 reference

12 December 2020

Mechanism of signaling by growth hormone receptor

1 reference

12 December 2020

Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus

1 reference

12 December 2020

Inhibitors of tyrosine kinase

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12 December 2020

Signal transduction by T- and B-cell antigen receptors: converging structures and concepts

1 reference

12 December 2020

Platelet-derived growth factor. Structure, function and implications in normal and malignant cell growth

1 reference

12 December 2020

Signal transduction by lymphocyte antigen receptors

1 reference

12 December 2020

Preferential inhibition of glioblastoma cells with wild-type epidermal growth factor receptors by a novel tyrosine kinase inhibitor ethyl-2,5-dihydroxycinnamate.

1 reference

12 December 2020

Signalling by receptor tyrosine kinases

1 reference

12 December 2020

Effect of herbimycin A on tyrosine kinase receptors and platelet derived growth factor (PDGF)-induced signal transduction

1 reference

12 December 2020

Nonreceptor tyrosine protein kinases.

1 reference

12 December 2020

A new acute transforming feline retrovirus with fms homology specifies a C-terminally truncated version of the c-fms protein that is different from SM-feline sarcoma virus v-fms protein.

1 reference

12 December 2020

Heterocondensed quinazolones: synthesis and protein-tyrosine kinase inhibitory activity of 3,4-dihydro-1H,6H-[1,4] oxazino-[3,4-b]quinazolin-6-one derivatives

1 reference

12 December 2020

A specific inhibitor of the epidermal growth factor receptor tyrosine kinase

1 reference

12 December 2020

Effects of the protein tyrosine kinase inhibitor, herbimycin A, on prolactin gene expression in GH3 and 235-1 pituitary tumor cells

1 reference

12 December 2020

Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase

1 reference

12 December 2020

EGFR blockade by tyrosine kinase inhibitor or monoclonal antibody inhibits growth, directs terminal differentiation and induces apoptosis in the human squamous cell carcinoma HN5.

1 reference

12 December 2020

Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin

1 reference

12 December 2020

Epidermal‐Growth‐Factor‐Dependent Activation of the Src‐Family Kinases

1 reference

12 December 2020

Protein tyrosine kinases and cancer

1 reference

12 December 2020

The v-sea oncogene of avian erythroblastosis retrovirus S13: another member of the protein-tyrosine kinase gene family

1 reference

12 December 2020

Roles of protein-tyrosine phosphatases in growth factor signalling

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12 December 2020

Vascular endothelial growth factor (VEGF) and its receptors

1 reference

12 December 2020

Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops

1 reference

12 December 2020

The HER-2/neu oncogene in breast cancer: prognostic factor, predictive factor, and target for therapy.

1 reference

12 December 2020

Cytokine receptors and signal transduction

1 reference

12 December 2020

Tyrosine kinase inhibitors. 6. Structure-activity relationships among N- and 3-substituted 2,2'-diselenobis(1H-indoles) for inhibition of protein tyrosine kinases and comparative in vitro and in vivo studies against selected sulfur congeners

1 reference

12 December 2020

Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor

1 reference

12 December 2020

Endothelial receptor tyrosine kinases involved in angiogenesis.

1 reference

12 December 2020

2-Substituted aminopyrido[2,3-d]pyrimidin-7(8H)-ones. structure-activity relationships against selected tyrosine kinases and in vitro and in vivo anticancer activity

1 reference

12 December 2020

The inhibitory effect of an EGF receptor-specific tyrosine kinase inhibitor on pancreatic cancer cell lines was more potent than inhibitory antibodies against the receptors for EGF and IGF I.

1 reference

12 December 2020

From form to function: signaling by protein tyrosine phosphatases.

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12 December 2020

Inhibition of the epidermal growth factor receptor tyrosine kinase by PD153035 in human A431 tumors in athymic nude mice

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12 December 2020

A potent protein-tyrosine kinase inhibitor which selectively blocks proliferation of epidermal growth factor receptor-expressing tumor cells in vitro and in vivo

1 reference

12 December 2020

Studies on a new epidermal growth factor-receptor kinase inhibitor, erbstatin, produced by MH435-hF3

1 reference

12 December 2020

Enhancement of chemosensitivity by tyrphostin AG825 in high-p185(neu) expressing non-small cell lung cancer cells

1 reference

12 December 2020

Tyrosine kinase inhibitors. 14. Structure-activity relationships for methylamino-substituted derivatives of 4-[(3-bromophenyl)amino]-6-(methylamino)-pyrido[3,4-d]pyrimidine (PD 158780), a potent and specific inhibitor of the tyrosine kinase activity

1 reference

12 December 2020

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1 reference

12 December 2020

Immunohistochemical evidence of autocrine growth factors in adenocarcinoma of the human lung

1 reference

12 December 2020

Identifiers

DOI

10.1023/A:1006372102543

1 reference

PubMed ID

10665475

Dimensions Publication ID

29 July 2017

0 references

1 reference

PubMed ID

10665475