New approaches to rational drug design (Q33832817)

29 July 2017

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title

New approaches to rational drug design (English)

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29 July 2017

Farber GK

1

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29 July 2017

1 December 1999

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Pharmacology & Therapeutics

29 July 2017

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29 July 2017

84

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29 July 2017

3

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29 July 2017

327-332

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Oligomerization of a 45 kilodalton fragment of diphtheria toxin at pH 5.0 to a molecule of 20-24 subunits

29 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

Effect of pH on the conformation of diphtheria toxin and its implications for membrane penetration

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

Structure of influenza haemagglutinin at the pH of membrane fusion

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

Influenza hemagglutinin is spring-loaded by a metastable native conformation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

Genome sequence of the nematode C. elegans: a platform for investigating biology

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

Ionic interactions in crystalline bovine pancreatic ribonuclease A

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

Assigning folds to the proteins encoded by the genome of Mycoplasma genitalium

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

Enzyme crystal structure in a neat organic solvent

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

X-ray crystal structure of cross-linked subtilisin Carlsberg in water vs. acetonitrile

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

Discovering high-affinity ligands for proteins

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https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

The methotrexate story: a paradigm for development of cancer chemotherapeutic agents.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

Triple-resonance multidimensional NMR study of calmodulin complexed with the binding domain of skeletal muscle myosin light-chain kinase: indication of a conformational change in the central helix

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

On the attribution and additivity of binding energies

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

Comparison of experimental and computational functional group mapping of an RNase A structure: implications for computer-aided drug design

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

Protein folding Folding with a two-stroke motor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

Engineering an anion-binding cavity in antichymotrypsin modulates the "spring-loaded" serpin-protease interaction

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

Analogous inhibitors of elastase do not always bind analogously

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

Taking a structured approach to understanding proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

The structure and evolution of alpha/beta barrel proteins

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https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

What makes a binding site a binding site?

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

Study of protein dynamics by X-ray diffraction

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

The crystal structure of subtilisin Carlsberg in anhydrous dioxane and its comparison with those in water and acetonitrile

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

Binding of Cyclopropane to Sperm Whale Myoglobin

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

Binding of xenon to sperm whale myoglobin.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

Discovering high-affinity ligands for proteins: SAR by NMR

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

Crystal structure at 2.6-A resolution of human macrophage migration inhibitory factor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

Direct link between cytokine activity and a catalytic site for macrophage migration inhibitory factor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

Cavities in proteins: structure of a metmyoglobin-xenon complex solved to 1.9 A.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

X-ray studies on cross-linked lysozyme crystals in acetonitrile-water mixture

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

The crystal structure of the asymmetric GroEL-GroES-(ADP)7 chaperonin complex

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

X-ray crystal structure of gamma-chymotrypsin in hexane

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

A Structural Explanation for Enzyme Memory in Nonaqueous Solvents

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

Adjustment of conformational flexibility is a key event in the thermal adaptation of proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

X-ray studies on two forms of bovine beta-trypsin crystals in neat cyclohexane

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2899%2900039-X

7 January 2021

10.1016/S0163-7258(99)00039-X

Identifiers

DOI

1 reference

29 July 2017

1 reference

PubMed ID

10665832