Novel insight from transgenic mice into thyroid hormone resistance and the regulation of thyrotropin (Q33835161)

29 July 2017

title

Novel insight from transgenic mice into thyroid hormone resistance and the regulation of thyrotropin (English)

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29 July 2017

E D Abel

1

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29 July 2017

H C Kaulbach

2

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29 July 2017

A Campos-Barros

3

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29 July 2017

R S Ahima

4

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29 July 2017

M E Boers

5

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29 July 2017

K Hashimoto

6

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29 July 2017

D Forrest

7

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29 July 2017

F E Wondisford

8

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29 July 2017

language of work or name

English

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publication date

1 January 1999

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Journal of Clinical Investigation

29 July 2017

published in

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29 July 2017

volume

103

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29 July 2017

issue

2

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29 July 2017

page(s)

271-279

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Distributions of leptin receptor mRNA isoforms in the rat brain

29 July 2017

cites work

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Selective pituitary resistance to thyroid hormone produced by expression of a mutant thyroid hormone receptor beta gene in the pituitary gland of transgenic mice

4 July 2018

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Tertiary hypothyroidism and hyperglycemia in mice with targeted disruption of the thyrotropin-releasing hormone gene

4 July 2018

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Transgenic mice bearing a human mutant thyroid hormone beta 1 receptor manifest thyroid function anomalies, weight reduction, and hyperactivity.

4 July 2018

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Nuclear receptor corepressors activate rather than suppress basal transcription of genes that are negatively regulated by thyroid hormone

4 July 2018

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Thyroid hormone resistance syndrome manifests as an aberrant interaction between mutant T3 receptors and transcriptional corepressors

4 July 2018

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Isoform variable action among thyroid hormone receptor mutants provides insight into pituitary resistance to thyroid hormone

4 July 2018

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A natural transactivation mutation in the thyroid hormone beta receptor: impaired interaction with putative transcriptional mediators.

4 July 2018

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A mouse model of resistance to thyroid hormone produced by somatic gene transfer of a mutant thyroid hormone receptor

4 July 2018

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Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor beta: evidence for tissue-specific modulation of receptor function

4 July 2018

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4 July 2018

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Evidence for the secretion of thyrotropin with enhanced bioactivity in syndromes of thyroid hormone resistance

4 July 2018

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Genetic analysis of 29 kindreds with generalized and pituitary resistance to thyroid hormone. Identification of thirteen novel mutations in the thyroid hormone receptor beta gene

4 July 2018

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Molecular mechanisms of dominant negative activity by nuclear hormone receptors.

4 July 2018

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Localization of promoter sequences required for thyrotropin-releasing hormone and thyroid hormone responsiveness of the glycoprotein hormone alpha-gene in primary cultures of rat pituitary cells

4 July 2018

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Ligand-Dependent and -Independent Transactivation by Thyroid Hormone Receptor β2 Is Determined by the Structure of the Hormone Response Element

4 July 2018

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Enhancer-mediated high level expression of mouse pituitary glycoprotein hormone alpha-subunit transgene in thyrotropes, gonadotropes, and developing pituitary gland.

4 July 2018

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Thyroid-pituitary interaction: feedback regulation of thyrotropin secretion by thyroid hormones

4 July 2018

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Hypothalamic hypothyroidism caused by lesions in rat paraventricular nuclei alters the carbohydrate structure of secreted thyrotropin

4 July 2018

1 reference

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Thyroid hormone regulates TRH biosynthesis in the paraventricular nucleus of the rat hypothalamus

4 July 2018

1 reference

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Thyrotropin-releasing hormone precursor: characterization in rat brain

4 July 2018

1 reference

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Decreased receptor binding of biologically inactive thyrotropin in central hypothyroidism. Effect of treatment with thyrotropin-releasing hormone

4 July 2018

1 reference

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Thyroid hormone regulates the mouse thyrotropin beta-subunit gene promoter in transfected primary thyrotropes

4 July 2018

1 reference

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Thyroid hormone inhibition of human thyrotropin beta-subunit gene expression is mediated by a cis-acting element located in the first exon

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=407884

Negative regulation of the thyroid-stimulating hormone alpha gene by thyroid hormone: receptor interaction adjacent to the TATA box

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=407884

A homozygous deletion in the c-erbA beta thyroid hormone receptor gene in a patient with generalized thyroid hormone resistance: isolation and characterization of the mutant receptor

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=407884

Thyrotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus is dependent upon feedback regulation by both triiodothyronine and thyroxine

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=407884

Thyroid hormone resistance: pathophysiology at the molecular level.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=407884

The Thyrotropin Receptor and the Regulation of Thyrocyte Function and Growth*

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=407884

Kindred S thyroid hormone receptor is an active and constitutive silencer and a repressor for thyroid hormone and retinoic acid responses

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=407884

Cloning of the mouse hypothalamic preprothyrotropin-releasing hormone (TRH) cDNA and tissue distribution of its mRNA

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=407884

Defective release of corepressor by hinge mutants of the thyroid hormone receptor found in patients with resistance to thyroid hormone.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=407884

AP-1 antagonizes thyroid hormone receptor action on the thyrotropin beta-subunit gene.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=407884

Spectrum of transcriptional, dimerization, and dominant negative properties of twenty different mutant thyroid hormone beta-receptors in thyroid hormone resistance syndrome.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=407884

Identification of thyroid hormone receptor isoforms in thyrotropin-releasing hormone neurons of the hypothalamic paraventricular nucleus

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=407884

Altered thyrotropin (TSH) carbohydrate structures in hypothalamic hypothyroidism created by paraventricular nuclear lesions are corrected by in vivo TSH-releasing hormone administration

29 October 2018

1 reference

12 December 2020

Triiodothyronine exerts direct cell-specific regulation of thyrotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus

1 reference

12 December 2020

The effect of hypothyroidism and thyrotoxicosis on thyroxine metabolism in the rat

1 reference

12 December 2020

Immunohistochemical localization of thyrotropin-releasing hormone in the rat hypothalamus and pituitary

1 reference

12 December 2020

Iodothyronine metabolism in liver and kidney homogenates from hyperthyroid and hypothyroid rats

1 reference

12 December 2020

The human thyrotropin-releasing hormone gene is regulated by thyroid hormone through two distinct classes of negative thyroid hormone response elements

1 reference

12 December 2020

Negative regulation of the glycoprotein hormone alpha gene promoter by thyroid hormone: mutagenesis of a proximal receptor binding site preserves transcriptional repression

1 reference

12 December 2020

Ligand-dependent antagonism by retinoid X receptors of inhibitory thyroid hormone response elements

1 reference

12 December 2020

Function of nuclear co-repressor protein on thyroid hormone response elements is regulated by the receptor A/B domain

1 reference

12 December 2020

Nuclear corepressors enhance the dominant negative activity of mutant receptors that cause resistance to thyroid hormone

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI5205

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29 July 2017

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29 July 2017

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