G1/S cell cycle arrest provides anoikis resistance through Erk-mediated Bim suppression (Q33836907)

29 July 2017

title

G1/S cell cycle arrest provides anoikis resistance through Erk-mediated Bim suppression (English)

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29 July 2017

6

Joan S Brugge

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29 July 2017

Nicole L Collins

1

1 reference

29 July 2017

Maurico J Reginato

2

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29 July 2017

Jessica K Paulus

3

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29 July 2017

Dennis C Sgroi

4

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29 July 2017

Joshua Labaer

5

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29 July 2017

language of work or name

English

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publication date

1 June 2005

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Molecular and Cellular Biology

29 July 2017

published in

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29 July 2017

volume

25

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29 July 2017

issue

12

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29 July 2017

page(s)

5282-5291

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Bim is an apoptosis sensor that responds to loss of survival signals delivered by epidermal growth factor but not those provided by integrins

29 July 2017

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4 July 2018

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Extracellular signal-regulated kinases 1/2 are serum-stimulated "Bim(EL) kinases" that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnover

4 July 2018

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Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.

4 July 2018

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4 July 2018

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4 July 2018

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Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.

4 July 2018

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Activation of ERK1/2 by deltaRaf-1:ER* represses Bim expression independently of the JNK or PI3K pathways

4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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Nerve growth factor (NGF) down-regulates the Bcl-2 homology 3 (BH3) domain-only protein Bim and suppresses its proapoptotic activity by phosphorylation

4 July 2018

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A novel form of constitutively active farnesylated Akt1 prevents mammary epithelial cells from anoikis and suppresses chemotherapy-induced apoptosis

4 July 2018

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IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation

4 July 2018

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4 July 2018

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Sensing the environment: a historical perspective on integrin signal transduction

4 July 2018

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Germ line transmission of the Cdk4(R24C) mutation facilitates tumorigenesis and escape from cellular senescence

4 July 2018

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Integrins and cell proliferation: regulation of cyclin-dependent kinases via cytoplasmic signaling pathways

4 July 2018

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4 July 2018

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A study of death by anoikis in cultured epithelial cells

4 July 2018

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Analysis of the transcriptional program induced by Raf in epithelial cells

4 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140593

The role of bim, a proapoptotic BH3-only member of the Bcl-2 family in cell-death control

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140593

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

4 July 2018

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4 July 2018

Cell cycle and apoptosis

1 reference

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MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-X(L), and Mcl-1 and promotes survival of human pancreatic cancer cells

4 July 2018

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Apoptosis, anoikis and their relevance to the pathobiology of colon cancer

4 July 2018

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Rb function in cell-cycle regulation and apoptosis

4 July 2018

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Cell-cycle inhibitors: three families united by a common cause

4 July 2018

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Mimosine arrests cells in G1 by enhancing the levels of p27(Kip1)

4 July 2018

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Cell adhesion: old and new questions

4 July 2018

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Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase

4 July 2018

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Cell cycle arrest and inhibition of anoikis by galectin-3 in human breast epithelial cells

4 July 2018

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Adhesion-mediated signaling in the regulation of mammary epithelial cell survival

4 July 2018

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CDK inhibitors: positive and negative regulators of G1-phase progression

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140593

Modulation of apoptosis by the cyclin-dependent kinase inhibitor p27(Kip1)

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140593

Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation

4 July 2018

1 reference

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Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase

4 July 2018

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Bim: a novel member of the Bcl-2 family that promotes apoptosis

4 July 2018

1 reference

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Integrins and anoikis

1 reference

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4 July 2018

1 reference

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4 July 2018

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4 July 2018

1 reference

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4 July 2018

1 reference

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Disruption of epithelial cell-matrix interactions induces apoptosis

4 July 2018

1 reference

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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29 October 2018

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29 October 2018

1 reference

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29 October 2018

1 reference

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Premature p34cdc2 activation required for apoptosis.

29 October 2018

1 reference

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29 October 2018

1 reference

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Persistence of solitary mammary carcinoma cells in a secondary site: a possible contributor to dormancy

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Cell cycle blockers mimosine, ciclopirox, and deferoxamine prevent the death of PC12 cells and postmitotic sympathetic neurons after removal of trophic support

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Apoptosis and the cell cycle

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p21WAF1/CIP1/SDI1 is elevated through a p53-independent pathway by mimosine

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10.1128/MCB.25.12.5282-5291.2005

Identifiers

DOI

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29 July 2017

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29 July 2017

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