Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites (Q33837172)

29 July 2017

Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites (English)

1 reference

29 July 2017

0 references

8

Ronald M Evans

0 references

author name string

Junichiro Sonoda

1

1 reference

29 July 2017

Ling Wa Chong

2

1 reference

29 July 2017

Michael Downes

3

1 reference

29 July 2017

Grant D Barish

4

1 reference

29 July 2017

Sally Coulter

5

1 reference

29 July 2017

Christopher Liddle

6

1 reference

29 July 2017

Chih-Hao Lee

7

1 reference

29 July 2017

language of work or name

English

0 references

publication date

25 January 2005

1 reference

Proceedings of the National Academy of Sciences of the United States of America

29 July 2017

1 reference

29 July 2017

102

1 reference

29 July 2017

6

1 reference

29 July 2017

2198-2203

1 reference

A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR.

29 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=548561

Induction of bilirubin clearance by the constitutive androstane receptor (CAR)

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=548561

Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=548561

The enzymes, regulation, and genetics of bile acid synthesis

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=548561

Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=548561

The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=548561

Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR).

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=548561

Software and methods for oligonucleotide and cDNA array data analysis

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=548561

Genetic defects in hepatobiliary transport.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=548561

Nuclear receptors and lipid physiology: opening the X-files

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=548561

Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=548561

Orphan nuclear receptors: the exotics of xenobiotics.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=548561

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=548561

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=548561

Differences in hepatic levels of intermediates in bile acid biosynthesis between Cyp27(-/-) mice and CTX.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=548561

Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=548561

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=548561

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=548561

Human UDP-glucuronosyltransferases: metabolism, expression, and disease

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=548561

The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=548561

Localization and function of the organic anion-transporting polypeptide Oatp2 in rat liver.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=548561

Features of Alagille syndrome in 92 patients: frequency and relation to prognosis

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=548561

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=548561

Unexpected clinical remission of cholestasis after rifampicin therapy in patients with normal or slightly increased levels of gamma-glutamyl transpeptidase

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=548561

Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=548561

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=548561

Incidence, predictive factors, and prognosis of the hepatorenal syndrome in cirrhosis with ascites

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=548561

Effects of long-term rifampicin administration in primary biliary cirrhosis

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=548561

Hypercholesterolemia and atherosclerosis in primary biliary cirrhosis: what is the risk?

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=548561

Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification

4 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0409481102

Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0409481102

Side chain hydroxylations in bile acid biosynthesis catalyzed by CYP3A are markedly up-regulated in Cyp27-/- mice but not in cerebrotendinous xanthomatosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0409481102

CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0409481102

Feed-forward regulation of bile acid detoxification by CYP3A4: studies in humanized transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0409481102

Cholesterol and cholate components of an atherogenic diet induce distinct stages of hepatic inflammatory gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0409481102

A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0409481102

The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0409481102

1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene, an extremely potent modulator of mouse hepatic cytochrome P-450 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0409481102

Resistance of SHP-null mice to bile acid-induced liver damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0409481102

Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0409481102

Bile system morphogenesis defects and liver dysfunction upon targeted deletion of HNF1beta.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=548561

Key regulatory oxysterols in liver: analysis as delta4-3-ketone derivatives by HPLC and response to physiological perturbations

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=548561

Abnormal lipoprotein pattern in patients with Alagille syndrome depends on Icterus severity

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15671183

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Molecular mechanisms of cholestasis: causes and consequences of impaired bile formation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15671183

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

INDUCTION OF GALLSTONES IN MICE BY FEEDING A CHOLESTEROL-CHOLIC ACID CONTAINING DIET

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15671183

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0409481102

1 reference

29 July 2017

0 references

1 reference

29 July 2017

1 reference