Extracellular chaperones modulate the effects of Alzheimer's patient cerebrospinal fluid on Abeta(1-42) toxicity and uptake (Q33838883)

29 July 2017

title

Extracellular chaperones modulate the effects of Alzheimer's patient cerebrospinal fluid on Abeta(1-42) toxicity and uptake (English)

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29 July 2017

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Justin J Yerbury

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29 July 2017

Mark R Wilson

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29 July 2017

publication date

27 May 2009

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29 July 2017

published in

Cell Stress & Chaperones

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29 July 2017

volume

15

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29 July 2017

issue

1

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29 July 2017

page(s)

115-121

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Potential roles of abundant extracellular chaperones in the control of amyloid formation and toxicity.

29 July 2017

cites work

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The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures

28 July 2018

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Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system

28 July 2018

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Enhanced sequence coverage of proteins in human cerebrospinal fluid using multiple enzymatic digestion and linear ion trap LC-MS/MS.

28 July 2018

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Quality control of protein folding in extracellular space

28 July 2018

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28 July 2018

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Metabolism of amyloid-beta peptide and Alzheimer's disease

28 July 2018

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Metals and amyloid-beta in Alzheimer's disease

28 July 2018

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28 July 2018

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28 July 2018

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Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

28 July 2018

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Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets

28 July 2018

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Clusterin is an ATP-independent chaperone with very broad substrate specificity that stabilizes stressed proteins in a folding-competent state

28 July 2018

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Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Clusterin protects against oxidative stress in vitro through aggregative and nonaggregative properties

28 July 2018

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28 July 2018

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Interaction of apolipoprotein J-amyloid beta-peptide complex with low density lipoprotein receptor-related protein-2/megalin. A mechanism to prevent pathological accumulation of amyloid beta-peptide

28 July 2018

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28 July 2018

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Clusterin (Apo J) protects against in vitro amyloid-beta (1-40) neurotoxicity

28 July 2018

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Apolipoprotein E epsilon 4 is associated with the presence and earlier onset of hemorrhage in cerebral amyloid angiopathy

28 July 2018

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28 July 2018

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SP-40,40, a newly identified normal human serum protein found in the SC5b-9 complex of complement and in the immune deposits in glomerulonephritis

28 July 2018

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Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

28 July 2018

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Detection of interleukin-6 and alpha 2-macroglobulin immunoreactivity in cortex and hippocampus of Alzheimer's disease patients

28 July 2018

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A derivative of the plasma protease inhibitor alpha(2)-macroglobulin regulates the response to peripheral nerve injury.

28 July 2018

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Clusterin in cerebrospinal fluid: analysis of carbohydrates and quantification of native and glycosylated forms.

29 October 2018

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Cerebrospinal fluid of Alzheimer patients promotes beta-amyloid fibril formation in vitro

29 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866977

Normal levels of clusterin in cerebrospinal fluid in Alzheimer's disease, and no change after acute ischemic stroke.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866977

Structure-function analysis of the antioxidant properties of haptoglobin

29 October 2018

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alpha 1-Proteinase inhibitor, alpha 1-antichymotrypsin, and alpha 2-macroglobulin are the antiapoptotic factors of vascular smooth muscle cells

29 October 2018

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Increased tau protein level in postmortem cerebrospinal fluid

29 October 2018

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Alpha2-macroglobulin complexes with and mediates the endocytosis of beta-amyloid peptide via cell surface low-density lipoprotein receptor-related protein.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866977

Deposition of apolipoproteins E and J in senile plaques is topographically determined in both Alzheimer's disease and Down's syndrome brain

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866977

Effects of Clusterin Overexpression on TNFα- and TGFβ-Mediated Death of L929 Cells†

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866977

Role of alpha2-macroglobulin in regulating amyloid beta-protein neurotoxicity: protective or detrimental factor?

29 October 2018

1 reference

12 December 2020

Neuroprotective effects of riluzole in ALS CSF toxicity

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12 December 2020

alpha2-Macroglobulin and haptoglobin suppress amyloid formation by interacting with prefibrillar protein species

1 reference

12 December 2020

On S. Seyfert, V. Kunzmann, N. Schwertfeger, H. C. Koch, A. Faulstich: Determinants of lumbar CSF protein concentration

1 reference

12 December 2020

CARE-LASS (calcein-release-assay), an improved fluorescence-based test system to measure cytotoxic T lymphocyte activity

1 reference

12 December 2020

Protease activation of alpha2-macroglobulin modulates a chaperone-like action with broad specificity

1 reference

12 December 2020

The acute phase protein haptoglobin is a mammalian extracellular chaperone with an action similar to clusterin

1 reference

12 December 2020

Clusterin is an extracellular chaperone that specifically interacts with slowly aggregating proteins on their off-folding pathway

1 reference

12 December 2020

Clusterin Has Chaperone-like Activity Similar to That of Small Heat Shock Proteins

1 reference

12 December 2020

10.1007/S12192-009-0122-0

Identifiers

DOI

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29 July 2017

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29 July 2017

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