Safety of non-antiarrhythmic drugs that prolong the QT interval or induce torsade de pointes: an overview (Q33844000)

29 July 2017

1 reference

title

Safety of non-antiarrhythmic drugs that prolong the QT interval or induce torsade de pointes: an overview (English)

1 reference

29 July 2017

Elisabetta Poluzzi

2

0 references

author name string

Fabrizio De Ponti

1

1 reference

29 July 2017

Andrea Cavalli

3

1 reference

29 July 2017

Maurizio Recanatini

4

1 reference

29 July 2017

Nicola Montanaro

5

1 reference

29 July 2017

1 January 2002

1 reference

29 July 2017

1 reference

29 July 2017

25

1 reference

29 July 2017

4

1 reference

29 July 2017

263-286

1 reference

https://scigraph.springernature.com/pub.10.2165/00002018-200225040-00004

29 July 2017

0 references

cites work

Relationship between QT interval and heart rate in Alderley Park beagles.

1 reference

Crossref

https://api.crossref.org/works/10.2165%2F00002018-200225040-00004

ISHNE guidelines for electrocardiographic evaluation of drug-related QT prolongation and other alterations in ventricular repolarization: task force summary. A report of the Task Force of the International Society for Holter and Noninvasive Electroc

21 January 2018

1 reference

12 December 2020

Prolongation of QT interval corrected for heart rate by Bazett's equation and linear formula as predictor of arrhythmic events after myocardial infarction.

1 reference

12 December 2020

The pre-clinical assessment of QT interval prolongation: a comparison of in vitro and in vivo methods

1 reference

12 December 2020

Dynamic analysis of the QT interval in long QT1 syndrome patients with a normal phenotype

1 reference

12 December 2020

Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death

1 reference

12 December 2020

The preclinical assessment of the risk for QT interval prolongation

1 reference

12 December 2020

QT dispersion in medicine: electrophysiological holy grail or fool's gold?

1 reference

12 December 2020

Mechanism of block and identification of the verapamil binding domain to HERG potassium channels

1 reference

12 December 2020

Potassium channels: molecular defects, diseases, and therapeutic opportunities.

1 reference

12 December 2020

Correct the QT interval correctly: QTc should be expressed in the same unit as the QT interval

1 reference

12 December 2020

Assessment of QTc prolongation for non-cardiac-related drugs from a drug development perspective

1 reference

12 December 2020

The assessment of potential for QT interval prolongation with new pharmaceuticals: impact on drug development

1 reference

12 December 2020

QTc-interval abnormalities and psychotropic drug therapy in psychiatric patients

1 reference

12 December 2020

A structural basis for drug-induced long QT syndrome

1 reference

12 December 2020

Structure and function of cardiac sodium and potassium channels

1 reference

12 December 2020

CYP2D6 and CYP2C19 genotypes of patients with terodiline cardiotoxicity identified through the yellow card system

1 reference

12 December 2020

Molecular determinants of dofetilide block of HERG K+ channels.

1 reference

12 December 2020

HERG K+ channels: friend and foe.

1 reference

12 December 2020

QT interval, heart rate and arterial pressures using propofol, thiopentone or methohexitone for induction of anaesthesia in children.

1 reference

12 December 2020

Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias.

1 reference

12 December 2020

QT interval prolongation and torsades de pointes due to erythromycin lactobionate

1 reference

12 December 2020

Is gender a risk factor for adverse drug reactions? The example of drug-induced long QT syndrome

1 reference

12 December 2020

Risk assessment for antimicrobial agent-induced QTc interval prolongation and torsades de pointes

1 reference

12 December 2020

Impaired fasting glucose, diabetes mellitus, and cardiovascular disease risk factors are associated with prolonged QTc duration. Results from the Third National Health and Nutrition Examination Survey.

1 reference

12 December 2020

Electrocardiographic assessment of antianxiety medication in dogs and correlation with serum drug concentration

1 reference

12 December 2020

Contraindicated medications dispensed with cisapride: temporal trends in relation to the sending of 'Dear Doctor' letters

1 reference

12 December 2020

Risk of torsades de pointes with non-cardiac drugs. Doctors need to be aware that many drugs can cause qt prolongation

1 reference

12 December 2020

Low penetrance in the long-QT syndrome: clinical impact

1 reference

12 December 2020

Screening for drug-induced (acquired) long QT syndrome: is it time to apply new methods?

1 reference

12 December 2020

Idiopathic prolonged QT interval and QT dispersion: the effects of propofol during implantation of cardioverter-defibrillator.

1 reference

12 December 2020

Female gender is a risk factor for drug-induced long QT and cardiac arrhythmias in an in vivo rabbit model

1 reference

12 December 2020

Downregulation of delayed rectifier K(+) currents in dogs with chronic complete atrioventricular block and acquired torsades de pointes

1 reference

12 December 2020

Changes in ventricular fibrillation threshold during acute hypothermia. A model for future studies

1 reference

12 December 2020

The missing second: what is the correct unit for the Bazett corrected QT interval?

1 reference

12 December 2020

The 1997 Stevenson Award Lecture. Cardiac K+ channel gating: cloned delayed rectifier mechanisms and drug modulation.

1 reference

12 December 2020

Differential effects of orally versus parenterally administered qinghaosu derivative artemether in dogs

1 reference

12 December 2020

Cocaine blocks HERG, but not KvLQT1+minK, potassium channels

1 reference

12 December 2020

QT prolongation and torsades de pointes induced by an antifungal agent, D0870, in conscious dogs

1 reference

12 December 2020

Molecular basis for the lack of HERG K+ channel block-related cardiotoxicity by the H1 receptor blocker cetirizine compared with other second-generation antihistamines

1 reference

12 December 2020

The effects of midazolam or propofol followed by suxamethonium on the QT interval in humans.

1 reference

12 December 2020

QT dispersion: time for an obituary?

1 reference

12 December 2020

Blockade of HERG and Kv1.5 by ketoconazole

1 reference

12 December 2020

Molecular biology and the prolonged QT syndromes

1 reference

12 December 2020

QT-interval prolongation by non-cardiac drugs: lessons to be learned from recent experience

1 reference

12 December 2020

Speculations on difference between tricyclic and selective serotonin reuptake inhibitor antidepressants on their cardiac effects. Is there any?

1 reference

12 December 2020

Block of human heart hH1 sodium channels by amitriptyline.

1 reference

12 December 2020

Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic

1 reference

12 December 2020

Evidence for a cardiac ion channel mutation underlying drug-induced QT prolongation and life-threatening arrhythmias

1 reference

12 December 2020

Methods of collecting and evaluating non-clinical cardiac electrophysiology data in the pharmaceutical industry: results of an international survey

1 reference

12 December 2020

The long QT syndromes: genetic basis and clinical implications

1 reference

12 December 2020

Progress in the understanding of cardiac early afterdepolarizations and torsades de pointes: time to revise current concepts

1 reference

12 December 2020

Drug-induced QT prolongation in women during the menstrual cycle

1 reference

12 December 2020

QSAR and CoMFA: a perspective on the practical application to drug discovery

1 reference

12 December 2020

QT prolongation and torsades de pointes after administration of trimethoprim-sulfamethoxazole

1 reference

12 December 2020

Comparative electrophysiologic and hemodynamic effects of several amide local anesthetic drugs in anesthetized dogs.

1 reference

12 December 2020

The heart of psychotropic drug therapy

1 reference

12 December 2020

3-D pharmacophores in drug discovery

1 reference

12 December 2020

The potential for QT prolongation and proarrhythmia by non-antiarrhythmic drugs: clinical and regulatory implications. Report on a policy conference of the European Society of Cardiology

1 reference

12 December 2020

Long-term treatment with antipsychotic drugs in conventional doses prolonged QTc dispersion, but did not increase ventricular tachyarrhythmias in patients with schizophrenia in the absence of cardiac disease

1 reference

12 December 2020

Effects of fluoroquinolones on HERG currents

1 reference

12 December 2020

Azimilide and dofetilide produce similar electrophysiological and proarrhythmic effects in a canine model of Torsade de Pointes arrhythmias

1 reference

12 December 2020

Flecainide: electrophysiologic and antiarrhythmic properties in refractory ventricular tachycardia

1 reference

12 December 2020

A common polymorphism associated with antibiotic-induced cardiac arrhythmia

1 reference

12 December 2020

Rate-corrected QT interval: techniques and limitations

1 reference

12 December 2020

The molecular and ionic specificity of antiarrhythmic drug actions

1 reference

12 December 2020

Rank power of metrics used to assess QTc interval prolongation by clinical trial simulation

1 reference

12 December 2020

Drugs that prolong QT interval as an unwanted effect: assessing their likelihood of inducing hazardous cardiac dysrhythmias

1 reference

12 December 2020

An animal model of spontaneous arrhythmic death

1 reference

12 December 2020

Levofloxacin induced polymorphic ventricular tachycardia with normal QT interval

1 reference

12 December 2020

Importance of QT interval determination and renal function assessment during antiarrhythmic drug therapy

1 reference

12 December 2020

QT lengthening and life-threatening arrhythmias associated with fexofenadine

1 reference

12 December 2020

Computer-assisted comparison of the structural and electronic dispositions of ebastine and terfenadine

1 reference

12 December 2020

Molecular determinant of high-affinity dofetilide binding to HERG1 expressed in Xenopus oocytes: involvement of S6 sites.

1 reference

12 December 2020

MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia

1 reference

12 December 2020

Experimental models of torsade de pointes

1 reference

12 December 2020

Inhibition of human ether-a-go-go potassium channels by cocaine

1 reference

12 December 2020

Sudden death, impaired glucose tolerance, and diabetes in Japanese American men.

1 reference

12 December 2020

Taking the "idio" out of "idiosyncratic": predicting torsades de pointes

1 reference

12 December 2020

Contraindicated use of cisapride: impact of food and drug administration regulatory action

1 reference

12 December 2020

Impact of a Web-based clinical information system on cisapride drug interactions and patient safety

1 reference

12 December 2020

Effect of imipramine on calcium and potassium currents in isolated bovine ventricular myocytes

1 reference

12 December 2020

Comparative effects of sodium bicarbonate and sodium chloride on reversing cocaine-induced changes in the electrocardiogram

1 reference

12 December 2020

QT corrected for heart rate and relation between QT and RR intervals in beagle dogs.

1 reference

12 December 2020

Sympathetic activation enhances QT prolongation by quinidine.

1 reference

12 December 2020

Time trends in the coprescribing of cisapride and contraindicated drugs in Umbria, Italy

1 reference

12 December 2020

A new approach for TU complex characterization.

1 reference

12 December 2020

Measurement, interpretation and clinical potential of QT dispersion.

1 reference

12 December 2020

The heart of psychotropic drug therapy

1 reference

12 December 2020

QT dispersion: an electrocardiographic derivative of QT prolongation

1 reference

12 December 2020

Comparison of formulae for heart rate correction of QT interval in exercise electrocardiograms

1 reference

12 December 2020

[3H]dofetilide binding to HERG transfected membranes: a potential high throughput preclinical screen.

1 reference

12 December 2020

Acquired long QT syndromes and the risk of proarrhythmia

1 reference

12 December 2020

Evaluation of 10 QT prediction formulas in 881 middle-aged men from the seven countries study: emphasis on the cubic root Fridericia's equation

1 reference

12 December 2020

Effects of nonsedating antihistamine, astemizole, on the in situ canine heart assessed by cardiohemodynamic and monophasic action potential monitoring

1 reference

12 December 2020

QT dispersion does not represent electrocardiographic interlead heterogeneity of ventricular repolarization

1 reference

12 December 2020

[Idiopathic long QT-syndrome. Changes in the duration of the QTC during anesthesia with propofol]

1 reference

12 December 2020

Organising evidence on QT prolongation and occurrence of Torsades de Pointes with non-antiarrhythmic drugs: a call for consensus

1 reference

12 December 2020

An improved method to correct the QT interval of the electrocardiogram for changes in heart rate.

1 reference

12 December 2020

Problems of heart rate correction in assessment of drug-induced QT interval prolongation.

1 reference

12 December 2020

The canine Purkinje fiber: an in vitro model system for acquired long QT syndrome and drug-induced arrhythmogenesis

1 reference

12 December 2020

Drug block of I(kr): model systems and relevance to human arrhythmias

1 reference

12 December 2020

Effects of a K(+) channel opener to reduce transmural dispersion of repolarization and prevent torsade de pointes in LQT1, LQT2, and LQT3 models of the long-QT syndrome

1 reference

12 December 2020

Cocaine abuse: repolarization abnormalities and ventricular arrhythmias

1 reference

12 December 2020

The heart rate-corrected QT interval of conscious beagle dogs: a formula based on analysis of covariance

1 reference

12 December 2020

KVLQT1 C-terminal missense mutation causes a forme fruste long-QT syndrome

1 reference

12 December 2020

Interactions of a series of fluoroquinolone antibacterial drugs with the human cardiac K+ channel HERG.

1 reference

12 December 2020

U wave: facts, hypotheses, misconceptions, and misnomers

1 reference

12 December 2020

Q-T interval prolongation in cirrhosis: prevalence, relationship with severity, and etiology of the disease and possible pathogenetic factors

1 reference

12 December 2020

1 reference

12 December 2020

The pharmacokinetics and pharmacodynamics of oral dofetilide after twice daily and three times daily dosing

1 reference

12 December 2020

Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole

1 reference

12 December 2020

The inhibitory effect of the antipsychotic drug haloperidol on HERG potassium channels expressed in Xenopus oocytes

1 reference

12 December 2020

The electrocardiographic QT interval and its prolongation in response to medications: differences between men and women

1 reference

12 December 2020

pH-dependent cocaine-induced cardiotoxicity

1 reference

12 December 2020

Acute canine model for drug-induced Torsades de Pointes in drug safety evaluation-influences of anesthesia and validation with quinidine and astemizole

1 reference

12 December 2020

Acquired long QT syndromes and the risk of proarrhythmia

1 reference

12 December 2020

Pharmacokinetics and pharmacodynamics of sotalol in a pediatric population with supraventricular and ventricular tachyarrhythmia

1 reference

12 December 2020

Safety of antihistamines in children

1 reference

12 December 2020

Errors in manual measurement of QT intervals

1 reference

12 December 2020

Ostensible day-night difference of QT prolongation during long-term treatment with antiarrhythmic drugs: reappraisal of the law of "regression to the mean"

1 reference

12 December 2020

QT interval prolongation by non-cardiovascular drugs: issues and solutions for novel drug development

1 reference

12 December 2020

New insights into the second generation antihistamines

1 reference

12 December 2020

Phase 2 early afterdepolarization as a trigger of polymorphic ventricular tachycardia in acquired long-QT syndrome : direct evidence from intracellular recordings in the intact left ventricular wall

1 reference

12 December 2020

An overview of class III electrophysiological agents: a new generation of antiarrhythmic therapy

1 reference

12 December 2020

Generalized seizures as the presentation of flecainide toxicity

1 reference

12 December 2020

Screening lead compounds for QT interval prolongation

1 reference

12 December 2020

Further characterization of the effects of imipramine on plateau membrane currents in guinea-pig ventricular myocytes

1 reference

12 December 2020

Centennial of the string galvanometer and the electrocardiogram

1 reference

12 December 2020

Evaluation of drug-induced QT interval prolongation: implications for drug approval and labelling

1 reference

12 December 2020

Drug-induced proarrhythmic effects: assessment of changes in QT interval

1 reference

12 December 2020

Ventricular hypertrophy amplifies transmural repolarization dispersion and induces early afterdepolarization

1 reference

12 December 2020

Block of HERG potassium channels by the antihistamine astemizole and its metabolites desmethylastemizole and norastemizole

1 reference

12 December 2020

Female gender as a risk factor for torsades de pointes associated with cardiovascular drugs

1 reference

12 December 2020

QT prolongation and paroxysmal ventricular tachycardia occurring during fever following trimethoprim-sulfamethoxazole administration

1 reference

12 December 2020

Effects of the antifungal agents on oxidative drug metabolism: clinical relevance

1 reference

12 December 2020

Gastrointestinal prokinetic drugs have different affinity for the human cardiac human ether-à-gogo K(+) channel

1 reference

12 December 2020

ERG proteins and functional cardiac I(Kr) channels in rat, mouse, and human heart.

1 reference

12 December 2020

I(Kr): the hERG channel

1 reference

12 December 2020

QT interval of the ECG, heart rate and arterial pressure using propofol, methohexital or midazolam for induction of anaesthesia.

1 reference

12 December 2020

Fluconazole-induced torsade de pointes

1 reference

12 December 2020

Long QT syndrome and torsade de pointes in a patient receiving fluconazole

1 reference

12 December 2020

Evolutionary changes in the electrocardiogram of severe progressive hypothermia

1 reference

12 December 2020

10.2165/00002018-200225040-00004

Identifiers

DOI

1 reference

Dimensions Publication ID

29 July 2017

0 references

1 reference