The role of senescence and immortalization in carcinogenesis (Q33846221)

29 July 2017

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title

The role of senescence and immortalization in carcinogenesis (English)

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29 July 2017

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Reddel RR

1

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PubMed ID

10688868

29 July 2017

language of work or name

English

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publication date

1 March 2000

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29 July 2017

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29 July 2017

21

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29 July 2017

3

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29 July 2017

477-484

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The serial cultivation of human diploid cell strains

29 July 2017

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Microarray analysis of replicative senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Replicative senescence: the human fibroblast comes of age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Origins of G1 arrest in senescent human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

21 January 2018

Coming of age in culture

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Replicative senescence: an old lives' tale?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Senescence as a mode of tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Telomere maintenance mechanisms and cellular immortalization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Extension of life-span by introduction of telomerase into normal human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

A reassessment of the telomere hypothesis of senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Restoration of the cellular senescence program and repression of telomerase by human chromosome 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

The RNA component of human telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

A survey of telomerase activity in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Identification of a specific telomere terminal transferase activity in Tetrahymena extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

A mammalian telomerase-associated protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Functional requirement of p23 and Hsp90 in telomerase complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Telomerase activity in normal and malignant hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

An alternative pathway for yeast telomere maintenance rescues est1- senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Mammalian telomeres end in a large duplex loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Repression of an alternative mechanism for lengthening of telomeres in somatic cell hybrids

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Control of replicative life span in human cells: barriers to clonal expansion intermediate between M1 senescence and M2 crisis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

p16(INK4a) and the control of cellular proliferative life span.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Essential role of mouse telomerase in highly proliferative organs

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Telomerase activity is sufficient to allow transformed cells to escape from crisis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Creation of human tumour cells with defined genetic elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Absence of cancer-associated changes in human fibroblasts immortalized with telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Analysis of genomic integrity and p53-dependent G1 checkpoint in telomerase-induced extended-life-span human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Inactivation of tumor suppressor p53 by mot-2, a hsp70 family member.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Decrease in amplified telomeric sequences and induction of senescence markers by introduction of human chromosome 7 or its segments in SUSM-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Differential effects of human papillomavirus type 6, 16, and 18 DNAs on immortalization and transformation of human cervical epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Suppression of tumor growth by senescence in virally transformed human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Induction of immortality is an early event in malignant transformation of mammalian cells by carcinogens.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

SV40-induced immortalization and ras-transformation of human bronchial epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Clonal variation of tumorigenic potential in v-Ha-ras-transformed human bronchial epithelial cells: relationship to ras oncogene expression and CAD gene amplification

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

A genetic model for colorectal tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

Replicative senescence: implications for in vivo aging and tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F21.3.477

21 January 2018

Identifiers

DOI

10.1093/CARCIN/21.3.477

1 reference

29 July 2017

1 reference

PubMed ID

10688868