Synthesis of chemically modified bioactive peptides: recent advances, challenges and developments for medicinal chemistry. (Q33852418)

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26 January 2020

review article

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title

Synthesis of chemically modified bioactive peptides: recent advances, challenges and developments for medicinal chemistry (English)

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26 January 2020

2

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26 January 2020

Norbert Sewald

series ordinal

3

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26 January 2020

author name string

Soledad Royo Gracia

series ordinal

1

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publication date

1 October 2009

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Future Medicinal Chemistry

26 January 2020

published in

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26 January 2020

volume

1

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26 January 2020

issue

7

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26 January 2020

page(s)

1289-1310

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

26 January 2020

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Synthesis of bicyclic alkene-/alkane-bridged nisin mimics by ring-closing metathesis and their biochemical evaluation as lipid II binders: toward the design of potential novel antibiotics.

21 January 2018

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Designing peptide receptor agonists and antagonists

21 January 2018

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Reversible backbone protection enables combinatorial solid-phase ring-closing metathesis reaction (RCM) in peptides.

21 January 2018

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Solid phase synthesis and structural analysis of novel A-chain dicarba analogs of human relaxin-3 (INSL7) that exhibit full biological activity

21 January 2018

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Synthesis and conformational analysis of a cyclic peptide obtained via i to i+4 intramolecular side-chain to side-chain azide-alkyne 1,3-dipolar cycloaddition

21 January 2018

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Side chain-to-side chain cyclization by click reaction

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Head-to-tail peptide cyclodimerization by copper-catalyzed azide-alkyne cycloaddition

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Efficient route to C2 symmetric heterocyclic backbone modified cyclic peptides

21 January 2018

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Click chemistry as a macrocyclization tool in the solid-phase synthesis of small cyclic peptides.

21 January 2018

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Copper(I)-catalyzed synthesis of azoles. DFT study predicts unprecedented reactivity and intermediates

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Probing the bioactive conformation of an archetypal natural product HDAC inhibitor with conformationally homogeneous triazole-modified cyclic tetrapeptides.

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Conformationally homogeneous heterocyclic pseudotetrapeptides as three-dimensional scaffolds for rational drug design: receptor-selective somatostatin analogues

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The Staudinger ligation-a gift to chemical biology.

21 January 2018

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Staudinger ligation: a peptide from a thioester and azide.

21 January 2018

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A "traceless" Staudinger ligation for the chemoselective synthesis of amide bonds

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Staudinger ligation of peptides at non-glycyl residues

21 January 2018

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Reaction mechanism and kinetics of the traceless Staudinger ligation

21 January 2018

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Convergent glycopeptide synthesis by traceless Staudinger ligation and enzymatic coupling

21 January 2018

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Water-soluble phosphinothiols for traceless staudinger ligation and integration with expressed protein ligation

21 January 2018

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Electronic and steric effects on the rate of the traceless Staudinger ligation

21 January 2018

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Development of a functional backbone cyclic mimetic of the HIV-1 Tat arginine-rich motif

21 January 2018

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Effect of structural and conformation modifications, including backbone cyclization, of hydrophilic hexapeptides on their intestinal permeability and enzymatic stability

21 January 2018

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Human somatostatin receptor specificity of backbone-cyclic analogues containing novel sulfur building units

21 January 2018

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Insect neuropeptide antagonist. Part II. Synthesis and biological activity of backbone cyclic and precyclic PBAN antagonists

21 January 2018

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Synthesis of a novel macrocyclic library: discovery of an IGF-1R inhibitor

21 January 2018

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Design and synthesis of potent and selective alpha(4)beta(7) integrin antagonists

21 January 2018

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Integrins: molecular targets in cancer therapy

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21 January 2018

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21 January 2018

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21 January 2018

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Rapid optimization of a peptide inhibitor of malaria parasite invasion by comprehensive N-methyl scanning

21 January 2018

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Diketopiperazines as a tool for the study of transport across the blood-brain barrier (BBB) and their potential use as BBB-shuttles

21 January 2018

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Main chain hydrogen bond interactions in the binding of proline-rich gluten peptides to the celiac disease-associated HLA-DQ2 molecule.

21 January 2018

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N- and Calpha-methylation in biologically active peptides: synthesis, structural and functional aspects.

21 January 2018

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Structure-activity relationship and metabolic stability studies of backbone cyclization and N-methylation of melanocortin peptides

21 January 2018

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N-Methyl scan of somatostatin octapeptide agonists produces interesting effects on receptor subtype specificity

21 January 2018

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Highly potent and subtype selective ligands derived by N-methyl scan of a somatostatin antagonist

21 January 2018

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Multiple N-methylation by a designed approach enhances receptor selectivity

21 January 2018

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Solid-phase synthesis and characterization of N-methyl-rich peptides.

21 January 2018

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Efficient, racemization-free peptide coupling of N-alkyl amino acids by using amino acid chlorides generated in situ--total syntheses of the cyclopeptides cyclosporin O and omphalotin A.

21 January 2018

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Convenient synthesis of N-methylamino acids compatible with Fmoc solid-phase peptide synthesis

21 January 2018

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Optimized selective N-methylation of peptides on solid support

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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β-Amino acid-containing hybrid peptides—new opportunities in peptidomimetics

21 January 2018

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Difficult Macrocyclizations: New Strategies for Synthesizing Highly Strained Cyclic Tetrapeptides

21 January 2018

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21 January 2018

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21 January 2018

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Improving Oral Bioavailability of Peptides by Multiple N-Methylation: Somatostatin Analogues

21 January 2018

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21 January 2018

Identifiers

DOI

10.4155/FMC.09.97

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21426104%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

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