Monitoring pharmacokinetics of anticancer drugs: non-invasive investigation using magnetic resonance spectroscopy (Q33852965)

29 July 2017

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title

Monitoring pharmacokinetics of anticancer drugs: non-invasive investigation using magnetic resonance spectroscopy (English)

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29 July 2017

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J R Griffiths

1

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29 July 2017

J D Glickson

series ordinal

2

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29 July 2017

language of work or name

English

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publication date

1 March 2000

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Advanced Drug Delivery Reviews

29 July 2017

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29 July 2017

41

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29 July 2017

1

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29 July 2017

75-89

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describes a project that uses

29 July 2017

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Monitoring local disposition kinetics of carboplatin in vivo after subcutaneous injection in rats by means of 195Pt NMR.

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Association of intratumoral pharmacokinetics of fluorouracil with clinical response

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Non-invasive 19F-NMRS of 5-fluorouracil in pharmacokinetics and pharmacodynamic studies

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Locoregional administration of 5-fluoro-2'-deoxyuridine (FdUrd) in Novikoff hepatoma in the rat: effects of dose and infusion time on tumor growth and on FdUrd metabolite levels in tumor tissue as determined by 19F-NMR spectroscopy

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19F MRS studies of fluoropyrimidine chemotherapy. A review

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Superiority of hepatic arterial infusion in preventing catabolism of 5-FU compared with portal vein infusion revealed by an in vivo 19F NMR study

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Intra- and extracellular fluorouracil uptake: assessment with contrast-enhanced metabolic F-19 MR imaging

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SLIM: spectral localization by imaging

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Localized spectroscopy from anatomically matched compartments: improved sensitivity and localization for cardiac 31P MRS in humans.

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In vivo 19F NMR spectroscopy of the antimetabolite 5-fluorouracil and its analogues. An assessment of drug metabolism

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Demonstration of tumor-selective retention of fluorinated nitroimidazole probes by 19F magnetic resonance spectroscopy in vivo

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Non-invasive MRS in new anticancer drug development

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Pharmacokinetic studies with the antifolate C2-desamino-C2-methyl-N10-propargyl-2'-trifluoromethyl-5,8-dideazafolic acid (CB3988) in mice and rats using in vivo 19F-NMR spectroscopy

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19F nuclear magnetic resonance imaging of drug distribution in vivo: the disposition of an antifolate anticancer drug in mice

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Phase I trial of temozolomide (CCRG 81045: M&B 39831: NSC 362856)

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Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials

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NMR and molecular modeling investigation of the mechanism of activation of the antitumor drug temozolomide and its interaction with DNA.

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The Charing Cross Hospital experience with temozolomide in patients with gliomas.

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Multicentre CRC phase II trial of temozolomide in recurrent or progressive high-grade glioma.

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Depletion of O6-alkylguanine-DNA alkyltransferase correlates with potentiation of temozolomide and CCNU toxicity in human tumour cells

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Pharmacokinetic assessment of novel anti-cancer drugs using spectral analysis and positron emission tomography: a feasibility study.

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Enhancement of nuclear magnetic resonance signals by polarization transfer

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In vivo proton spectroscopy and spectroscopic imaging of [1-13C]-glucose and its metabolic products.

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7 January 2021

1H-Observe/13C-decouple spectroscopic measurements of lactate and glutamate in the rat brain in vivo

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7 January 2021

Pharmacokinetics of the 13C labeled anticancer agent temozolomide detected in vivo by selective cross-polarization transfer

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The relationship between regional variations in blood flow and histology in a transplanted rat fibrosarcoma

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Are cancer cells acidic?

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Proton detection of choline and lactate in EMT6 tumors by spin-echo-enhanced selective multiple-quantum-coherence transfer

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Correction of motional artifacts in diffusion-weighted MR images using navigator echoes.

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A comparative binding of platinum anti-tumour compounds to plasma proteins in the rat (in vivo) and mouse (in vitro)

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7 January 2021

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Identifiers

DOI

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29 July 2017

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