Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-beta after vascular damage (Q33853378)

29 July 2017

Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-beta after vascular damage (English)

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29 July 2017

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8

Katerina Akassoglou

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29 July 2017

Christian Schachtrup

1

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29 July 2017

Jae K Ryu

2

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29 July 2017

Matthew J Helmrick

3

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29 July 2017

Eirini Vagena

4

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29 July 2017

Dennis K Galanakis

5

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29 July 2017

Jay L Degen

6

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29 July 2017

Richard U Margolis

7

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29 July 2017

language of work or name

English

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publication date

1 April 2010

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29 July 2017

Journal of Neuroscience

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29 July 2017

30

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29 July 2017

5843-5854

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29 July 2017

17

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describes a project that uses

29 July 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2871011/fullTextXML

inferred from PubMed Central ID database lookup

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Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix

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Fibrinogen signal transduction as a mediator and therapeutic target in inflammation: lessons from multiple sclerosis

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5 July 2018

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T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation

5 July 2018

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Fibrinogen and fibrin: scaffold proteins in hemostasis

5 July 2018

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Absence of integrin-mediated TGFbeta1 activation in vivo recapitulates the phenotype of TGFbeta1-null mice

5 July 2018

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The fibrin-derived gamma377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease

5 July 2018

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Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology

5 July 2018

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Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy

5 July 2018

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Integrin-mediated transforming growth factor-beta activation regulates homeostasis of the pulmonary epithelial-mesenchymal trophic unit

5 July 2018

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Identification of an ordered compact structure within the recombinant bovine fibrinogen alphaC-domain fragment by NMR.

5 July 2018

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Astrocyte-endothelial interactions at the blood-brain barrier

5 July 2018

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Reactive astrocytes in neural repair and protection

5 July 2018

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Fibrinogen heterogeneity: inherited and noninherited

5 July 2018

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Growth factor and cytokine regulation of chondroitin sulfate proteoglycans by astrocytes.

5 July 2018

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Integrin alpha(v)beta8-mediated activation of transforming growth factor-beta by perivascular astrocytes: an angiogenic control switch

5 July 2018

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Transglutaminase-mediated oligomerization of the fibrin(ogen) alphaC domains promotes integrin-dependent cell adhesion and signaling.

5 July 2018

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Fibrin mechanisms and functions in nervous system pathology

5 July 2018

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Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1.

5 July 2018

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Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis.

5 July 2018

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Reactive astrocytes protect tissue and preserve function after spinal cord injury

5 July 2018

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5 July 2018

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The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injury

5 July 2018

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Making sense of latent TGFbeta activation

5 July 2018

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Akt1 regulates a JNK scaffold during excitotoxic apoptosis

5 July 2018

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Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth

5 July 2018

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The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1

5 July 2018

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Chondroitinase ABC promotes functional recovery after spinal cord injury

5 July 2018

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Nervous system pathology: the fibrin perspective

5 July 2018

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

5 July 2018

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Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines

5 July 2018

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Developmental regulation of alphav integrins produces functional changes in astrocyte behavior.

5 July 2018

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The structure and biological features of fibrinogen and fibrin.

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871011

Characteristics of sustained blood-brain barrier opening and tissue injury in a model for focal trauma in the rat.

5 July 2018

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Role of transforming growth factor beta in human disease

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871011

Latent transforming growth factor-beta binding proteins (LTBPs)--structural extracellular matrix proteins for targeting TGF-beta action

5 July 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871011

5 July 2018

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TGF-beta in blood: a complex problem

29 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871011

The glial scar and central nervous system repair

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871011

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871011

The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871011

Crystal structure of a recombinant alphaEC domain from human fibrinogen-420

5 July 2018

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TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871011

Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin

5 July 2018

1 reference

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TAG-1/axonin-1 is a high-affinity ligand of neurocan, phosphacan/protein-tyrosine phosphatase-zeta/beta, and N-CAM

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871011

TGF-beta receptors and actions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871011

The neuronal chondroitin sulfate proteoglycan neurocan binds to the neural cell adhesion molecules Ng-CAM/L1/NILE and N-CAM, and inhibits neuronal adhesion and neurite outgrowth

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871011

Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871011

Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871011

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871011

Global analysis of Smad2/3-dependent TGF-beta signaling in living mice reveals prominent tissue-specific responses to injury.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871011

Interleukin-1beta but not IL-1alpha binds to fibrinogen and fibrin and has enhanced activity in the bound form.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871011

alphaVbeta8 integrin is a Schwann cell receptor for fibrin

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871011

FGF-2 but not FGF-1 binds fibrin and supports prolonged endothelial cell growth

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871011

Expression of TGFbeta2 but not TGFbeta1 correlates with the deposition of scar tissue in the lesioned spinal cord.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871011

Latent TGF-beta binding protein LTBP-1 contains three potential extracellular matrix interacting domains.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871011

Bovine CNS myelin contains neurite growth-inhibitory activity associated with chondroitin sulfate proteoglycans.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871011

Cellular and molecular mechanisms of glial scarring and progressive cavitation: in vivo and in vitro analysis of inflammation-induced secondary injury after CNS trauma.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871011

The preparation and properties of human fibrinogen of relatively high solubility

29 October 2018

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12 December 2020

Human fibrinogen heterogeneities. I. Structural and related studies of plasma fibrinogens which are high solubility catabolic intermediates

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12 December 2020

Regulation of hepatic stellate cell differentiation by the neurotrophin receptor p75NTR

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12 December 2020

Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice

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12 December 2020

Release and activation of platelet latent TGF-beta in blood clots during dissolution with plasmin

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12 December 2020

Acute inflammatory responses to mechanical lesions in the CNS: differences between brain and spinal cord

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12 December 2020

The chondroitin sulfate proteoglycans neurocan and phosphacan are expressed by reactive astrocytes in the chronic CNS glial scar

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12 December 2020

Neurocan is upregulated in injured brain and in cytokine-treated astrocytes

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12 December 2020

Vascular endothelial growth factor binds to fibrinogen and fibrin and stimulates endothelial cell proliferation

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12 December 2020

Fibrin inhibits peripheral nerve remyelination by regulating Schwann cell differentiation

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12 December 2020

Homophenotypic Aalpha R16H fibrinogen (Kingsport): uniquely altered polymerization associated with slower fibrinopeptide A than fibrinopeptide B release

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12 December 2020

The pro domain of pre-pro-transforming growth factor beta 1 when independently expressed is a functional binding protein for the mature growth factor

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12 December 2020

Blood-brain barrier damage in acute multiple sclerosis plaques. An immunocytological study

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12 December 2020

Molecular mechanisms of initiation of fibrinolysis by fibrin

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12 December 2020

10.1523/JNEUROSCI.0137-10.2010

Identifiers

DOI

1 reference

29 July 2017

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29 July 2017

1 reference