ras-p21-induced cell transformation: unique signal transduction pathways and implications for the design of new chemotherapeutic agents (Q33853704)

29 July 2017

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title

ras-p21-induced cell transformation: unique signal transduction pathways and implications for the design of new chemotherapeutic agents (English)

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29 July 2017

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Pincus MR

1

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29 July 2017

Brandt-Rauf PW

2

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29 July 2017

Michl J

3

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29 July 2017

Carty RP

4

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29 July 2017

Friedman FK

5

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29 July 2017

publication date

1 January 2000

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29 July 2017

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29 July 2017

volume

18

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29 July 2017

issue

1

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29 July 2017

page(s)

39-50

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https://api.crossref.org/works/10.3109%2F07357900009023061

29 July 2017

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Transformation of NIH 3T3 cells by microinjection of Ha-ras p21 protein

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

The p21 ras C-terminus is required for transformation and membrane association

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

Dominant inhibitory Ras mutants selectively inhibit the activity of either cellular or oncogenic Ras.

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

Evidence that oocyte maturation induced by an oncogenic ras-p21 protein and insulin is mediated by overlapping yet distinct mechanisms

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

Pseudodipeptide inhibitors of protein farnesyltransferase

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

Two dominant inhibitory mutants of p21ras interfere with insulin-induced gene expression.

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

Mutational analysis of a ras catalytic domain

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

Biology of the Rap proteins, members of the ras superfamily of GTP-binding proteins

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

Atomic structure of the MAP kinase ERK2 at 2.3 A resolution

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

Phosphatidylinositol-3-OH kinase as a direct target of Ras

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

The structural basis of the activation of Ras by Sos

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

Peptides containing a consensus Ras binding sequence from Raf-1 and theGTPase activating protein NF1 inhibit Ras function

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

Insulin stimulation of a MEK-dependent but ERK-independent SOS protein kinase

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

Inhibition of serum- and ras-stimulated DNA synthesis by antibodies to phospholipase C.

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

Evidence that the ras oncogene-encoded p21 protein induces oocyte maturation via activation of protein kinase C

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

Phospholipase C-gamma 1 can induce DNA synthesis by a mechanism independent of its lipase activity

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

The regulation of AP-1 activity by mitogen-activated protein kinases

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G 1

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

Structural significance of the GTP-binding domain of ras p21 studied by site-directed mutagenesis

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

Structure and energetics of ligand binding to proteins: Escherichia coli dihydrofolate reductase-trimethoprim, a drug-receptor system.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357900009023061

On the multiple-minima problem in the conformational analysis of polypeptides. II. An electrostatically driven Monte Carlo method--tests on poly(L-alanine).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357900009023061

Comparison of the computed three-dimensional structures of oncogenic forms (bound to GDP) of the ras-gene-encoded p21 protein with the structure of the normal (non-transforming) wild-type protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357900009023061

Selective inhibition of oncogenic ras-p21 in vivo by agents that block its interaction with jun-N-kinase (JNK) and jun proteins. Implications for the design of selective chemotherapeutic agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357900009023061

Permanent conversion of mouse and human cells transformed by activated ras or raf genes to apparently normal cells by treatment with the antibiotic azatyrosine

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

Oncogenic ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

Control of p34cdc2 Activation

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

Identification of an intracellular protein that specifically interacts with photoaffinity-labeled oncogenic p21 protein

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

Activation of c-Jun-NH2-kinase by UV irradiation is dependent on p21ras

21 January 2018

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https://api.crossref.org/works/10.3109%2F07357900009023061

Complexes of p21RAS with JUN N-terminal kinase and JUN proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357900009023061

Inhibition of oncogenic and activated wild-type ras-p21 protein-induced oocyte maturation by peptides from the ras-binding domain of the raf-p74 protein, identified from molecular dynamics calculations

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F07357900009023061

10.3109/07357900009023061

21 January 2018

Identifiers

DOI

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29 July 2017

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