Pharmacology of ramelteon, a selective MT1/MT2 receptor agonist: a novel therapeutic drug for sleep disorders (Q33854026)

29 July 2017

5 references

25 April 2019

31 July 2019

7 November 2019

13 November 2019

15 December 2019

Pharmacology of ramelteon, a selective MT1/MT2 receptor agonist: a novel therapeutic drug for sleep disorders (English)

1 reference

29 July 2017

5 references

25 April 2019

31 July 2019

7 November 2019

13 November 2019

15 December 2019

cell surface receptor

1 reference

31 July 2019

1 reference

7 November 2019

1 reference

13 November 2019

1 reference

15 December 2019

Masaomi Miyamoto

1

1 reference

29 July 2017

publication date

1 January 2009

1 reference

CNS Neuroscience & Therapeutics

29 July 2017

published in

6 references

29 July 2017

25 April 2019

31 July 2019

7 November 2019

13 November 2019

15 December 2019

15

1 reference

29 July 2017

issue

1

1 reference

29 July 2017

page(s)

32-51

1 reference

Creative Commons Attribution 2.5 Generic

29 July 2017

copyright license

1 reference

Creative Commons Attribution

25 April 2019

4 references

31 July 2019

7 November 2019

13 November 2019

15 December 2019

0 references

on focus list of Wikimedia project

ScienceSource

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cites work

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Ramelteon (TAK-375), a selective MT1/MT2-receptor agonist, reduces latency to persistent sleep in a model of transient insomnia related to a novel sleep environment

5 July 2018

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Benefit-risk assessment of zaleplon in the treatment of insomnia

5 July 2018

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The human pineal gland and melatonin in aging and Alzheimer's disease

5 July 2018

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Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist

5 July 2018

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The sleep-promoting action of ramelteon (TAK-375) in freely moving cats

5 July 2018

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Residual effects of hypnotics: epidemiology and clinical implications

5 July 2018

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Abuse and dependence potential for the non-benzodiazepine hypnotics zolpidem and zopiclone: a review of case reports and epidemiological data

5 July 2018

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Molecular pharmacology, regulation and function of mammalian melatonin receptors

5 July 2018

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Importance and relevance of melatonin to human biological rhythms

5 July 2018

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New drugs for insomnia: comparative tolerability of zopiclone, zolpidem and zaleplon

5 July 2018

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Non-benzodiazepines for the treatment of insomnia

5 July 2018

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Targeted disruption of the mouse Mel(1b) melatonin receptor

5 July 2018

1 reference

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Mammalian melatonin receptors: molecular biology and signal transduction.

5 July 2018

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The use of melatonin in Alzheimer's disease.

5 July 2018

1 reference

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Effects of melatonin administration on daytime sleep after simulated night shift work

5 July 2018

1 reference

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Melatonin treatment for age-related insomnia.

5 July 2018

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Evidence for a biological dawn and dusk in the human circadian timing system

5 July 2018

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Melatonin for the prevention and treatment of jet lag.

5 July 2018

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Effects of hypnotics on the sleep EEG of healthy young adults: new data and psychopharmacologic implications

5 July 2018

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Identification of the melatonin-binding site MT3 as the quinone reductase 2.

5 July 2018

1 reference

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Zaleplon improves sleep without producing rebound effects in outpatients with insomnia. Zaleplon Clinical Study Group.

5 July 2018

1 reference

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Nonselective and selective benzodiazepine receptor agonists--where are we today?

5 July 2018

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Zaleplon and triazolam in humans: acute behavioral effects and abuse potential

5 July 2018

1 reference

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Characterization of 2-[125I]iodomelatonin binding sites in Syrian hamster peripheral organs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871175

Selective MT2 melatonin receptor antagonists block melatonin-mediated phase advances of circadian rhythms

5 July 2018

1 reference

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The role of melatonin and circadian phase in age-related sleep-maintenance insomnia: assessment in a clinical trial of melatonin replacement

5 July 2018

1 reference

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Efficacy of melatonin as a sleep-promoting agent

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871175

Molecular dissection of two distinct actions of melatonin on the suprachiasmatic circadian clock.

5 July 2018

1 reference

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Pharmacokinetics and oral bioavailability of exogenous melatonin in preclinical animal models and clinical implications

5 July 2018

1 reference

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Melatonin receptors step into the light: cloning and classification of subtypes

5 July 2018

1 reference

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Recent developments in the behavioral pharmacology of benzodiazepine (omega) receptors: evidence for the functional significance of receptor subtypes

5 July 2018

1 reference

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Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses

5 July 2018

1 reference

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Melatonin receptors: are there multiple subtypes?

5 July 2018

1 reference

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Zolpidem in the treatment of transient insomnia: a double-blind, randomized comparison with placebo.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871175

Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871175

Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a)

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871175

Hypnotics and the control of breathing: a review

5 July 2018

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Plasma melatonin--an index of brain aging in humans?

5 July 2018

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HPLC-purified 2-[125I]iodomelatonin labels multiple binding sites in hamster brain

5 July 2018

1 reference

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A role for the mesolimbic dopamine system in the reinforcing properties of diazepam

5 July 2018

1 reference

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Effect of benzodiazepine hypnotics on all-night sleep EEG spectra.

5 July 2018

1 reference

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Comparison of triazolam and pentobarbital: performance impairment, subjective effects and abuse liability.

5 July 2018

1 reference

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Zolpidem and triazolam in humans: behavioral and subjective effects and abuse liability.

5 July 2018

1 reference

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Daily variation in the concentration of melatonin and 5-methoxytryptophol in the human pineal gland: effect of age and Alzheimer's disease.

5 July 2018

1 reference

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Pharmacological characterization of melatonin binding sites in Syrian hamster hypothalamus.

5 July 2018

1 reference

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Effect of zolpidem on sleep and sleep EEG spectra in healthy young men.

5 July 2018

1 reference

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Delayed sleep phase syndrome response to melatonin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871175

Circadian rhythm abnormalities in totally blind people: incidence and clinical significance

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871175

Circadian rhythms and the suprachiasmatic nucleus in perinatal development, aging and Alzheimer's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871175

Zolpidem behavioral pharmacology in baboons: self-injection, discrimination, tolerance and withdrawal

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871175

A 2-night, 3-period, crossover study of ramelteon's efficacy and safety in older adults with chronic insomnia.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871175

Ramelteon: a novel hypnotic lacking abuse liability and sedative adverse effects.

29 October 2018

1 reference

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Efficacy and safety of zolpidem-MR: a double-blind, placebo-controlled study in adults with primary insomnia.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871175

Acute and chronic effects of ramelteon in rhesus monkeys (Macaca mulatta): dependence liability studies.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871175

Effects of ramelteon on patient-reported sleep latency in older adults with chronic insomnia.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871175

Prolonged assessment of sleep and daytime sleepiness in unrestrained Macaca mulatta.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871175

Disposition kinetics and tolerance of escalating single doses of ramelteon, a high-affinity MT1 and MT2 melatonin receptor agonist indicated for treatment of insomnia

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871175

An efficacy, safety, and dose-response study of Ramelteon in patients with chronic primary insomnia

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871175

An assessment of the efficacy and safety of eszopiclone in the treatment of transient insomnia in healthy adults

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871175

Ramelteon (TAK-375) accelerates reentrainment of circadian rhythm after a phase advance of the light-dark cycle in rats

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871175

Effects of ramelteon (TAK-375) on nocturnal sleep in freely moving monkeys

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871175

Melatonin treatment of day-night rhythm disturbances and sundowning in Alzheimer disease: an open-label pilot study using actigraphy

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871175

Sustained efficacy of eszopiclone over 6 months of nightly treatment: results of a randomized, double-blind, placebo-controlled study in adults with chronic insomnia

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871175

Serum melatonin and urinary 6-sulfatoxymelatonin in major depression

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871175

Double blind study of melatonin effects on the sleep-wake rhythm, cognitive and non-cognitive functions in Alzheimer type dementia

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871175

Zolpidem dependence case series: possible neurobiological mechanisms and clinical management

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871175

Dose-response effects of zaleplon as compared with triazolam (0.25 mg) and placebo in chronic primary insomnia.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871175

Pilot study comparing in blind the therapeutic effect of two doses of agomelatine, melatoninergic agonist and selective 5HT2C receptors antagonist, in the treatment of major depressive disorders

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871175

Synthesis of a novel series of tricyclic indan derivatives as melatonin receptor agonists

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871175

Comparative pharmacological studies of melatonin receptors: MT1, MT2 and MT3/QR2. Tissue distribution of MT3/QR2 .

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871175

Comparison of the effects of zaleplon, zolpidem, and triazolam on memory, learning, and psychomotor performance.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871175

Effect of zopiclone and temazepam on sleep EEG parameters, psychomotor and memory functions in healthy elderly volunteers.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871175

Independent sleep EEG slow-wave and spindle band dynamics associated with 4 weeks of continuous application of short-half-life hypnotics in healthy subjects.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871175

Delayed sleep phase syndrome: A placebo-controlled cross-over study on the effects of melatonin administered five hours before the individual dim light melatonin onset.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871175

Melatonin replacement therapy of elderly insomniacs.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871175

The association between the nocturnal sleep gate and nocturnal onset of urinary 6-sulfatoxymelatonin.

29 October 2018

1 reference

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Sleep-inducing effects of low doses of melatonin ingested in the evening.

29 October 2018

1 reference

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Melatonin and delayed sleep phase syndrome: ambulatory polygraphic evaluation.

29 October 2018

1 reference

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Melatonin inhibits cyclic AMP and cyclic GMP accumulation in the rat pituitary

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2871175

Effect of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist, on motor performance in mice

29 October 2018

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12 December 2020

Nocturnal melatonin and 24-hour 6-sulphatoxymelatonin levels in various phases of bipolar affective disorder

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Effects of low oral doses of melatonin, given 2-4 hours before habitual bedtime, on sleep in normal young humans

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Melatonin and adjustment to phase shift

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12 December 2020

Improvement of sleep quality by controlled-release melatonin in benzodiazepine-treated elderly insomniacs

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Melatonin excretion, body temperature and subjective arousal during 64 hours of sleep deprivation

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12 December 2020

Effects of lorazepam on memory, attention and sedation in man: antagonism by Ro 15-1788.

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Neuroendocrine aspects of primary endogenous depression. XI. Serum melatonin measures in patients and matched control subjects

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10.1111/J.1755-5949.2008.00066.X

Identifiers

DOI

1 reference

29 July 2017

1 reference

29 July 2017

1 reference