The role of SLP-76 and LAT in lymphocyte development (Q33860548)

29 July 2017

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title

The role of SLP-76 and LAT in lymphocyte development (English)

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29 July 2017

Pivniouk VI

1

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29 July 2017

Geha RS

series ordinal

2

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29 July 2017

publication date

1 April 2000

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Current Opinion in Immunology

29 July 2017

published in

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29 July 2017

volume

12

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29 July 2017

issue

2

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29 July 2017

page(s)

173-178

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Structure and function of the pre-T cell receptor

29 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Early T lymphocyte progenitors

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

RAG-1-deficient mice have no mature B and T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

The CD3gamma chain is essential for development of both the TCRalphabeta and TCRgammadelta lineages

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

T cell development in mice lacking the CD3-zeta/eta gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Profound block in thymocyte development in mice lacking p56lck

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

T cell antigen receptor signal transduction pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

TcR zeta/CD3 signal transduction in T-cells: downstream signalling via ZAP-70, SLP-76 and FYB.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function

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https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

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https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

The role of Grb2-associated proteins in T-cell activation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

BLNK: a central linker protein in B cell activation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Localization of LAT in glycolipid-enriched microdomains is required for T cell activation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Linker for activation of T cells (LAT), a novel immunohistochemical marker for T cells, NK cells, mast cells, and megakaryocytes: evaluation in normal and pathological conditions

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Lck regulates Vav activation of members of the Rho family of GTPases

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

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https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Differential signaling by lymphocyte antigen receptors.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNK

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

FYN-T-FYB-SLP-76 interactions define a T-cell receptor zeta/CD3-mediated tyrosine phosphorylation pathway that up-regulates interleukin 2 transcription in T-cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Essential role of LAT in T cell development

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

CD3 epsilon-mediated signals rescue the development of CD4+CD8+ thymocytes in RAG-2-/- mice in the absence of TCR beta chain expression.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Restoration of thymopoiesis in pT alpha-/- mice by anti-CD3epsilon antibody treatment or with transgenes encoding activated Lck or tailless pT alpha.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Regulation of thymocyte development through CD3: Functional dissociation between p56lck and CD3ζ in early thymic selection

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Allelic exclusion of the T cell receptor beta locus requires the SH2 domain-containing leukocyte protein (SLP)-76 adaptor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Allelic exclusion in pTalpha-deficient mice: no evidence for cell surface expression of two T cell receptor (TCR)-beta chains, but less efficient inhibition of endogeneous Vbeta--> (D)Jbeta rearrangements in the presence of a functional TCR-beta tra

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

NK cytokine secretion and cytotoxicity occur independently of the SLP-76 adaptor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Pleiotropic changes controlled by the pre-T-cell receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Essential role of the pre-T cell receptor in allelic exclusion of the T cell receptor beta locus.

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

The CD3-gammadeltaepsilon and CD3-zeta/eta modules are each essential for allelic exclusion at the T cell receptor beta locus but are both dispensable for the initiation of V to (D)J recombination at the T cell receptor-beta, -gamma, and -delta loci

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

T lymphocyte development in p56lck deficient mice: allelic exclusion of the TcR β locus is incomplete but thymocyte development is not restored by TcR β or TcR αβ transgenes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

In transgenic mice the introduced functional T cell receptor beta gene prevents expression of endogenous beta genes

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Immature thymocytes employ distinct signaling pathways for allelic exclusion versus differentiation and expansion

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

Distinct signals mediate maturation and allelic exclusion in lymphocyte progenitors

1 reference

https://api.crossref.org/works/10.1016%2FS0952-7915%2899%2900068-0

7 January 2021

10.1016/S0952-7915(99)00068-0

Identifiers

DOI

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29 July 2017

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