ZD6474, a multitargeted inhibitor for receptor tyrosine kinases, suppresses growth of gliomas expressing an epidermal growth factor receptor mutant, EGFRvIII, in the brain (Q33870872)

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English	ZD6474, a multitargeted inhibitor for receptor tyrosine kinases, suppresses growth of gliomas expressing an epidermal growth factor receptor mutant, EGFRvIII, in the brain	scientific article

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30 January 2020

ZD6474, a multitargeted inhibitor for receptor tyrosine kinases, suppresses growth of gliomas expressing an epidermal growth factor receptor mutant, EGFRvIII, in the brain (English)

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30 January 2020

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30 January 2020

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Jia-Jean Yiin

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30 January 2020

Bo Hu

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30 January 2020

Paul A Schornack

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30 January 2020

Raghvendra S Sengar

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30 January 2020

Kun-Wei Liu

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30 January 2020

Frank S Lieberman

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30 January 2020

Shih-Hwa Chiou

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30 January 2020

Jann N Sarkaria

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30 January 2020

Erik C Wiener

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30 January 2020

Hsin-I Ma

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30 January 2020

Shi-Yuan Cheng

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6 April 2010

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30 January 2020

Molecular Cancer Therapeutics

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30 January 2020

9

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30 January 2020

4

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30 January 2020

929-941

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30 January 2020

Targeted therapy for malignant glioma patients: lessons learned and the road ahead

1 reference

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Vandetanib (ZD6474), an inhibitor of VEGFR and EGFR signalling, as a novel molecular-targeted therapy against cholangiocarcinoma

1 reference

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ADP-ribosylation factor 6 regulates glioma cell invasion through the IQ-domain GTPase-activating protein 1-Rac1-mediated pathway

1 reference

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Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators

1 reference

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Vandetanib inhibits growth of adenoid cystic carcinoma in an orthotopic nude mouse model.

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Malignant gliomas in adults

1 reference

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Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

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5 July 2018

Effects of the VEGFR inhibitor ZD6474 in combination with radiotherapy and temozolomide in an orthotopic glioma model

1 reference

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5 July 2018

Antiangiogenic compounds interfere with chemotherapy of brain tumors due to vessel normalization.

1 reference

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Investigation of two dosing schedules of vandetanib (ZD6474), an inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling, in combination with irinotecan in a human colon cancer xenograft model.

1 reference

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Malignant astrocytic glioma: genetics, biology, and paths to treatment

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5 July 2018

Chemoradiotherapy in malignant glioma: standard of care and future directions

1 reference

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5 July 2018

Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma

1 reference

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5 July 2018

Induction of cell cycle arrest and apoptosis in human nasopharyngeal carcinoma cells by ZD6474, an inhibitor of VEGFR tyrosine kinase with additional activity against EGFR tyrosine kinase.

1 reference

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Targeted therapy of orthotopic human lung cancer by combined vascular endothelial growth factor and epidermal growth factor receptor signaling blockade

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Synergistic antitumor activity of ZD6474, an inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling, with gemcitabine and ionizing radiation against pancreatic cancer.

1 reference

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5 July 2018

ZD6474, a novel tyrosine kinase inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor, inhibits tumor growth of multiple nervous system tumors

1 reference

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5 July 2018

Evaluation of the functional diffusion map as an early biomarker of time-to-progression and overall survival in high-grade glioma

1 reference

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5 July 2018

Cooperative antitumor effect of multitargeted kinase inhibitor ZD6474 and ionizing radiation in glioblastoma

1 reference

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ZD6474, a potent inhibitor of vascular endothelial growth factor signaling, combined with radiotherapy: schedule-dependent enhancement of antitumor activity.

1 reference

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1 reference

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Dynamic, contrast-enhanced perfusion MRI in mouse gliomas: correlation with histopathology

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Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase.

1 reference

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1 reference

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1 reference

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12 December 2020

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30 January 2020

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