Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis (Q33877517)

29 July 2017

Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis (English)

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29 July 2017

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Christian Cole

1

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Sara J Brown

Sara J Brown

11

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Geoffrey J. Barton

Geoffrey J Barton

9

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Alan D. Irvine

Alan D Irvine

10

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Nicholas Schurch

Nicholas J Schurch

3

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Aileen Sandilands

4

Aileen Sandilands

1 reference

29 July 2017

2

Karin Kroboth

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29 July 2017

6

Grainne M O'Regan

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29 July 2017

7

Rosemarie M Watson

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29 July 2017

8

W H Irwin McLean

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29 July 2017

Alexander Sherstnev

5

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PubMed ID

24880632

29 July 2017

language of work or name

English

0 references

publication date

28 May 2014

1 reference

The Journal of Allergy and Clinical Immunology

29 July 2017

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29 July 2017

134

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1

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82-91

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PubMed ID

24880632

describes a project that uses

29 July 2017

edgeR

EdgeR

1 reference

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

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Guidelines of care for the management of atopic dermatitis: section 1. Diagnosis and assessment of atopic dermatitis

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Cell death by cornification

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Atopic dermatitis results in intrinsic barrier and immune abnormalities: implications for contact dermatitis

5 July 2018

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Comparative transcriptomic analyses of atopic dermatitis and psoriasis reveal shared neutrophilic inflammation.

5 July 2018

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Mechanisms of IFN-γ-induced apoptosis of human skin keratinocytes in patients with atopic dermatitis

5 July 2018

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IL-17 downregulates filaggrin and affects keratinocyte expression of genes associated with cellular adhesion

5 July 2018

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Filaggrin genotype determines functional and molecular alterations in skin of patients with atopic dermatitis and ichthyosis vulgaris

5 July 2018

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Intragenic copy number variation within filaggrin contributes to the risk of atopic dermatitis with a dose-dependent effect

5 July 2018

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Filaggrin mutations associated with skin and allergic diseases.

5 July 2018

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Filaggrin genotype in ichthyosis vulgaris predicts abnormalities in epidermal structure and function

5 July 2018

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Human atopic dermatitis complicated by eczema herpeticum is associated with abnormalities in IFN-γ response

5 July 2018

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Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity.

5 July 2018

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5 July 2018

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Raman profiles of the stratum corneum define 3 filaggrin genotype-determined atopic dermatitis endophenotypes

5 July 2018

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Chromosome 11q13.5 variant associated with childhood eczema: an effect supplementary to filaggrin mutations

5 July 2018

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Dynamic and physical clustering of gene expression during epidermal barrier formation in differentiating keratinocytes

5 July 2018

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5 July 2018

Direct RNA sequencing

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Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum.

5 July 2018

1 reference

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Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens

5 July 2018

1 reference

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Filaggrin haploinsufficiency is highly penetrant and is associated with increased severity of eczema: further delineation of the skin phenotype in a prospective epidemiological study of 792 school children.

5 July 2018

1 reference

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5 July 2018

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Phenotype of atopic dermatitis subjects with a history of eczema herpeticum.

5 July 2018

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Filaggrin in the frontline: role in skin barrier function and disease

5 July 2018

1 reference

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Global expression profiling in atopic eczema reveals reciprocal expression of inflammatory and lipid genes

5 July 2018

1 reference

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Revealing the architecture of gene regulation: the promise of eQTL studies

5 July 2018

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5 July 2018

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Genetics of gene expression and its effect on disease

5 July 2018

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A systems biology approach to anatomic diversity of skin

5 July 2018

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Basis for the barrier abnormality in atopic dermatitis: outside-inside-outside pathogenic mechanisms

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4090750

Cytokine modulation of atopic dermatitis filaggrin skin expression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4090750

Major differences in inflammatory dendritic cells and their products distinguish atopic dermatitis from psoriasis.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4090750

Early cutaneous gene transcription changes in adult atopic dermatitis and potential clinical implications

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4090750

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4090750

Transcriptional regulation of the cartilage intermediate layer protein (CILP) gene

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4090750

Clinical practice. Atopic dermatitis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4090750

The cornified envelope: a model of cell death in the skin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4090750

One of two chondrocyte‐expressed isoforms of cartilage intermediate‐layer protein functions as an insulin‐like growth factor 1 antagonist

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4090750

T cell-mediated Fas-induced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4090750

Filaggrin breakdown to water binding compounds during development of the rat stratum corneum is controlled by the water activity of the environment.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4090750

Knock-down of filaggrin does not affect lipid organization and composition in stratum corneum of reconstructed human skin equivalents.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4090750

Electron diffraction study of lipids in non-lesional stratum corneum of atopic eczema patients

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4090750

Transcriptional profiling after lipid raft disruption in keratinocytes identifies critical mediators of atopic dermatitis pathways.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4090750

Molecular diagnostics of psoriasis, atopic dermatitis, allergic contact dermatitis and irritant contact dermatitis.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4090750

DNA microarray analyses and interactomic predictions for atopic dermatitis.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4090750

The Nottingham Eczema Severity Score: preliminary refinement of the Rajka and Langeland grading.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4090750

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4090750

Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4090750

Proceedings of the 4th Georg Rajka International Symposium on Atopic Dermatitis, Arcachon, France, September 15-17, 2005

29 October 2018

1 reference

12 December 2020

Loss-of-Function Mutations in the Filaggrin Gene Lead to Reduced Level of Natural Moisturizing Factor in the Stratum Corneum

1 reference

12 December 2020

Meta-analysis of filaggrin polymorphisms in eczema and asthma: Robust risk factors in atopic disease

1 reference

12 December 2020

Broad defects in epidermal cornification in atopic dermatitis identified through genomic analysis

1 reference

12 December 2020

Interleukin-22 downregulates filaggrin expression and affects expression of profilaggrin processing enzymes

1 reference

12 December 2020

Altered penetration of polyethylene glycols into uninvolved skin of atopic dermatitis patients

1 reference

12 December 2020

Distinct patterns of gene expression in the skin lesions of atopic dermatitis and psoriasis: a gene microarray analysis

1 reference

12 December 2020

Large-scale DNA microarray analysis of atopic skin lesions shows overexpression of an epidermal differentiation gene cluster in the alternative pathway and lack of protective gene expression in the cornified envelope

1 reference

12 December 2020

10.1016/J.JACI.2014.04.021

Identifiers

DOI

1 reference

29 July 2017

1 reference

29 July 2017

1 reference

PubMed ID

24880632