4SC-101, a novel small molecule dihydroorotate dehydrogenase inhibitor, suppresses systemic lupus erythematosus in MRL-(Fas)lpr mice (Q33882490)

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1 February 2020

title

4SC-101, a novel small molecule dihydroorotate dehydrogenase inhibitor, suppresses systemic lupus erythematosus in MRL-(Fas)lpr mice (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20413687%20AND%20SRC:MED&resulttype=core&format=json

systemic lupus erythematosus

1 February 2020

main subject

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author

Hans-Joachim Anders

11

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9

Aldo Ammendola

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1 February 2020

author name string

Onkar P Kulkarni

1

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1 February 2020

Sufyan G Sayyed

2

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Claudia Kantner

3

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1 February 2020

Mi Ryu

4

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1 February 2020

Max Schnurr

5

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Miklós Sárdy

6

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Johann Leban

7

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Ruediger Jankowsky

8

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Robert Doblhofer

10

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language of work or name

English

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publication date

22 April 2010

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The American Journal of Pathology

1 February 2020

published in

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volume

176

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issue

6

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page(s)

2840-2847

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Mycophenolate mofetil versus cyclophosphamide for induction treatment of lupus nephritis

1 February 2020

cites work

1 reference

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Anti-Ccl2 Spiegelmer permits 75% dose reduction of cyclophosphamide to control diffuse proliferative lupus nephritis and pneumonitis in MRL-Fas(lpr) mice

5 July 2018

1 reference

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Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites

5 July 2018

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Expression and regulation of Toll-like receptors in lupus-like immune complex glomerulonephritis of MRL-Fas(lpr) mice

5 July 2018

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Leflunomide: an immunomodulatory drug for the treatment of rheumatoid arthritis and other autoimmune diseases

5 July 2018

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Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents

5 July 2018

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Disease modifying activity of HWA 486 on the development of SLE in MRL/1-mice.

5 July 2018

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Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease

5 July 2018

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Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis

5 July 2018

1 reference

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4SC-101, a novel immunosuppressive drug, inhibits IL-17 and attenuates colitis in two murine models of inflammatory bowel disease

5 July 2018

1 reference

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Induction treatment of proliferative lupus nephritis with leflunomide combined with prednisone: a prospective multi-centre observational study

29 October 2018

1 reference

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Leflunomide-induced subacute cutaneous lupus erythematosus with erythema multiforme-like lesions

29 October 2018

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Systemic lupus erythematosus.

29 October 2018

1 reference

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Leflunomide in subacute cutaneous lupus erythematosus - two sides of a coin

29 October 2018

1 reference

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Safety and efficacy of leflunomide in the treatment of lupus nephritis refractory or intolerant to traditional immunosuppressive therapy: an open label trial.

29 October 2018

1 reference

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Toll-like receptor-4: renal cells and bone marrow cells signal for neutrophil recruitment during pyelonephritis.

29 October 2018

1 reference

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Subacute cutaneous lupus erythematosus precipitated by leflunomide

29 October 2018

1 reference

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SAR, species specificity, and cellular activity of cyclopentene dicarboxylic acid amides as DHODH inhibitors

29 October 2018

1 reference

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Double-blind, randomized, placebo-controlled pilot study of leflunomide in systemic lupus erythematosus

29 October 2018

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Efficacy and safety of leflunomide in the treatment of psoriatic arthritis and psoriasis: a multinational, double-blind, randomized, placebo-controlled clinical trial

29 October 2018

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Serial determination of glomerular filtration rate in conscious mice using FITC-inulin clearance

29 October 2018

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Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: a double-blind, randomised, multicentre trial. European Leflunomide Study Group.

29 October 2018

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Systemic lupus erythematosus

29 October 2018

1 reference

12 December 2020

Dihydroorotate dehydrogenase. Profile of a novel target for antiproliferative and immunosuppressive drugs

1 reference

12 December 2020

Systemic lupus erythematosus

1 reference

12 December 2020

Spiegelmer inhibition of CCL2/MCP-1 ameliorates lupus nephritis in MRL-(Fas)lpr mice

1 reference

12 December 2020

Chemokine expression precedes inflammatory cell infiltration and chemokine receptor and cytokine expression during the initiation of murine lupus nephritis

1 reference

12 December 2020

Deficiency in beta(2)-microglobulin, but not CD1, accelerates spontaneous lupus skin disease while inhibiting nephritis in MRL-Fas(lpr) nice: an example of disease regulation at the organ level

1 reference

12 December 2020

Diffuse proliferative lupus nephritis: identification of specific pathologic features affecting renal outcome

1 reference

12 December 2020

Therapy of lupus nephritis. Controlled trial of prednisone and cytotoxic drugs

1 reference

12 December 2020

10.2353/AJPATH.2010.091227

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20413687%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20413687%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

PubMed publication ID

20413687

1 reference