Metabolic engineering and directed evolution for the production of pharmaceuticals (Q33884992)

29 July 2017

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title

Metabolic engineering and directed evolution for the production of pharmaceuticals (English)

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29 July 2017

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Chartrain M

1

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29 July 2017

Salmon PM

series ordinal

2

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29 July 2017

Robinson DK

series ordinal

3

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29 July 2017

Buckland BC

series ordinal

4

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29 July 2017

1 April 2000

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Current Opinion in Biotechnology

29 July 2017

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29 July 2017

11

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29 July 2017

2

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29 July 2017

209-214

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Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering

29 July 2017

1 reference

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Tolerance and specificity of polyketide synthases

1 reference

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The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases

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Novel erythromycins from a recombinant Saccharopolyspora erythraea strain NRRL 2338 pIG1. I. Fermentation, isolation and biological activity

1 reference

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A chain initiation factor common to both modular and aromatic polyketide synthases

1 reference

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Spontaneous priming of a downstream module in 6-deoxyerythronolide B synthase leads to polyketide biosynthesis

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7 January 2021

Dissecting and exploiting intermodular communication in polyketide synthases

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7 January 2021

Evaluating precursor-directed biosynthesis towards novel erythromycins through in vitro studies on a bimodular polyketide synthase

1 reference

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7 January 2021

Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units

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7 January 2021

Harnessing the biosynthetic code: combinations, permutations, and mutations

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7 January 2021

Mechanism and specificity of the terminal thioesterase domain from the erythromycin polyketide synthase

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7 January 2021

Ectopic expression of the minimal whiE polyketide synthase generates a library of aromatic polyketides of diverse sizes and shapes

1 reference

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7 January 2021

The Streptomyces peucetius dpsY anddnrX Genes Govern Early and Late Steps of Daunorubicin and Doxorubicin Biosynthesis

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Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene

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A two-plasmid system for the glycosylation of polyketide antibiotics: bioconversion of epsilon-rhodomycinone to rhodomycin D

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7 January 2021

Production of the antitumor drug epirubicin (4'-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius

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7 January 2021

Self-sufficient biosynthesis of pregnenolone and progesterone in engineered yeast

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Novel biosynthetic approaches to the production of unnatural amino acids using transaminases

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Production of the carotenoids lycopene, beta-carotene, and astaxanthin in the food yeast Candida utilis

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Production of lycopene by the food yeast, Candida utilis that does not naturally synthesize carotenoid

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7 January 2021

Increased carotenoid production by the food yeast Candida utilis through metabolic engineering of the isoprenoid pathway.

1 reference

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7 January 2021

Engineered isoprenoid pathway enhances astaxanthin production in Escherichia coli

1 reference

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7 January 2021

Biocatalysis for pharmaceuticals--status and prospects for a key technology

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Isolation and characterization of indene bioconversion genes from Rhodococcus strain I24

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7 January 2021

Novel approaches for discovering industrial enzymes

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7 January 2021

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1 reference

7 January 2021

Applications of oxidoreductases

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7 January 2021

Dehalogenases applied to industrial-scale biocatalysis

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7 January 2021

The power of evolution: accessing the synthetic potential of P450s

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7 January 2021

Chemical modification of enzymes for enhanced functionality

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7 January 2021

Biocatalysts for clean industrial products and processes

1 reference

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7 January 2021

Improved green fluorescent protein by molecular evolution using DNA shuffling.

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7 January 2021

Directed evolution of a para-nitrobenzyl esterase for aqueous-organic solvents

1 reference

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7 January 2021

Directed evolution of biocatalysts

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7 January 2021

Directed evolution of an esterase for the stereoselective resolution of a key intermediate in the synthesis of epothilones

1 reference

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7 January 2021

Molecular evolution by staggered extension process (StEP) in vitro recombination

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7 January 2021

Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation

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7 January 2021

A high-throughput digital imaging screen for the discovery and directed evolution of oxygenases

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7 January 2021

A general strategy for enzyme engineering

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7 January 2021

Directed evolution converts subtilisin E into a functional equivalent of thermitase

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7 January 2021

Directed evolution of a thermostable esterase.

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7 January 2021

A structural view of evolutionary divergence

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7 January 2021

Functional expression of horseradish peroxidase in E. coli by directed evolution

1 reference

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7 January 2021

The Streptomyces peucetius dpsC Gene Determines the Choice of Starter Unit in Biosynthesis of the Daunorubicin Polyketide

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.1128/JB.181.15.4690-4695.1999

Identifiers

DOI

10.1016/S0958-1669(00)00081-1

1 reference

29 July 2017

1 reference