Applications of mass spectrometry to metabolomics and metabonomics: detection of biomarkers of aging and of age-related diseases (Q33888328)

29 July 2017

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title

Applications of mass spectrometry to metabolomics and metabonomics: detection of biomarkers of aging and of age-related diseases (English)

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29 July 2017

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Robert J Mishur

1

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PubMed ID

21538458

29 July 2017

Shane L Rea

series ordinal

2

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29 July 2017

28 April 2011

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Mass Spectrometry Reviews

29 July 2017

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29 July 2017

31

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29 July 2017

70-95

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29 July 2017

1

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Integrated ionization approach for RRLC-MS/MS-based metabonomics: finding potential biomarkers for lung cancer

29 July 2017

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Observation of A2E oxidation products in human retinal lipofuscin

21 January 2018

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Use of meso- tetrakis(pentafluorophenyl)porphyrin as a matrix for low molecular weight alkylphenol ethoxylates in laser desorption/ ionization time-of-flight mass spectrometry

21 January 2018

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Metabolomics applied to diabetes research: moving from information to knowledge

21 January 2018

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Characterization of a new rat urinary metabolite of piperine by LC/NMR/MS studies.

21 January 2018

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Formation of a nonaoxirane from A2E, a lipofuscin fluorophore related to macular degeneration, and evidence of singlet oxygen involvement

21 January 2018

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Metabotyping of Caenorhabditis elegans reveals latent phenotypes

21 January 2018

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Shattuck lecture--cardiovascular medicine at the turn of the millennium: triumphs, concerns, and opportunities.

21 January 2018

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Predicting the future burden of cancer.

21 January 2018

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Forecasting the global burden of Alzheimer’s disease

21 January 2018

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Long-lived mitochondrial (Mit) mutants of Caenorhabditis elegans utilize a novel metabolism

21 January 2018

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Newborn screening of inborn errors of metabolism by capillary electrophoresis-electrospray ionization-mass spectrometry: a second-tier method with improved specificity and sensitivity

21 January 2018

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Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography mass spectrometry (GC/MS).

21 January 2018

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Practical approach for the identification and isomer elucidation of biomarkers detected in a metabonomic study for the discovery of individuals at risk for diabetes by integrating the chromatographic and mass spectrometric information

21 January 2018

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Metabonomics study of liver cancer based on ultra performance liquid chromatography coupled to mass spectrometry with HILIC and RPLC separations

21 January 2018

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RRLC-MS/MS-based metabonomics combined with in-depth analysis of metabolic correlation network: finding potential biomarkers for breast cancer.

21 January 2018

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Metabolomics of gastric cancer metastasis detected by gas chromatography and mass spectrometry

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Plasma metabolomics reveals biomarkers of the atherosclerosis

21 January 2018

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Probing single secretory vesicles with capillary electrophoresis

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Causes and prevalence of visual impairment among adults in the United States

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Metabolomic and flux-balance analysis of age-related decline of hypoxia tolerance in Drosophila muscle tissue

21 January 2018

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21 January 2018

Support-vector networks

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Metabolomic applications of HILIC-LC-MS.

21 January 2018

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Metabonomics and population studies: age-related amino acids excretion and inferring networks through the study of urine samples in two Italian isolated populations.

21 January 2018

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Mass spectrometry-based metabolic profiling reveals different metabolite patterns in invasive ovarian carcinomas and ovarian borderline tumors.

21 January 2018

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Metabolite profiling of human colon carcinoma--deregulation of TCA cycle and amino acid turnover

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Mass spectrometry-based metabolomics

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Gene selection and classification of microarray data using random forest.

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The photochemical oxidation of A2E results in the formation of a 5,8,5',8'-bis-furanoid oxide

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Measuring the metabolome: current analytical technologies

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Metabolomic analysis of eukaryotic tissue and prokaryotes using negative mode MALDI time-of-flight mass spectrometry

21 January 2018

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Metabolic pathway profiling of mitochondrial respiratory chain mutants in C. elegans.

21 January 2018

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Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM)

21 January 2018

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A liquid chromatography-quadrupole time-of-flight (LC-QTOF)-based metabolomic approach reveals new metabolic effects of catechin in rats fed high-fat diets

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Combining genomics, metabolome analysis, and biochemical modelling to understand metabolic networks

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Extending healthy life span--from yeast to humans

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Free amino acid and dipeptide changes in the body fluids from Alzheimer's disease subjects

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Genome-scale reconstruction of the Saccharomyces cerevisiae metabolic network

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alpha-hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population

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High temperature-ultra performance liquid chromatography-mass spectrometry for the metabonomic analysis of Zucker rat urine

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Metabolic profiles of cancer cells

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1H NMR metabolomics study of age profiling in children

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Ovarian cancer detection from metabolomic liquid chromatography/mass spectrometry data by support vector machines.

21 January 2018

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21 January 2018

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Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis

21 January 2018

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Prediction of breast cancer by profiling of urinary RNA metabolites using Support Vector Machine-based feature selection.

21 January 2018

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Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry.

21 January 2018

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Colorectal cancer screening: today and tomorrow

21 January 2018

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21 January 2018

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Standardizing GC-MS metabolomics.

21 January 2018

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Quantitation of low molecular mass substrates and products of enzyme catalyzed reactions using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

21 January 2018

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21 January 2018

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Metabolomics and systems biology: making sense of the soup

21 January 2018

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Metabolic footprinting and systems biology: the medium is the message

21 January 2018

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21 January 2018

The genetics of ageing

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A comprehensive urinary metabolomic approach for identifying kidney cancerr

21 January 2018

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Acid-induced denaturation of myoglobin studied by time-resolved electrospray ionization mass spectrometry.

21 January 2018

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Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye.

21 January 2018

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Metabolomics: opening another window into aging

21 January 2018

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Metabolomics in the study of aging and caloric restriction

21 January 2018

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Possible degradation/biotransformation of lutein in vitro and in vivo: isolation and structural elucidation of lutein metabolites by HPLC and LC-MS (atmospheric pressure chemical ionization).

21 January 2018

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Capillary electrophoresis with electrospray ionization mass spectrometric detection for single-cell metabolomics

21 January 2018

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Analysis of the adult human plasma metabolome

21 January 2018

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Differential rates of glutathione oxidation for assessment of cellular redox status and antioxidant capacity by capillary electrophoresis-mass spectrometry: an elusive biomarker of oxidative stress.

21 January 2018

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Comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry for metabonomics: Biomarker discovery for diabetes mellitus

21 January 2018

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Plasma metabolic profiling of Alzheimer's disease by liquid chromatography/mass spectrometry

21 January 2018

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LC-MS-based metabonomics analysis

21 January 2018

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Gas chromatography/time-of-flight mass spectrometry based metabonomic approach to differentiating hypertension- and age-related metabolic variation in spontaneously hypertensive rats

21 January 2018

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A metabonomic analysis of plasma from Zucker rat strains using gas chromatography/mass spectrometry and pattern recognition.

21 January 2018

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Development and validation of a gas chromatography/mass spectrometry method for the metabolic profiling of human colon tissue

21 January 2018

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On-line detection of human skin vapors.

21 January 2018

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Optimization and evaluation of metabolite extraction protocols for untargeted metabolic profiling of liver samples by UPLC-MS.

21 January 2018

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Highly sensitive matrix-assisted laser desorption ionization-mass spectrometry for high-throughput metabolic profiling

21 January 2018

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Metabolome analysis by capillary electrophoresis-mass spectrometry

21 January 2018

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Modifications to the basement membrane protein laminin using glycolaldehyde and A2E: a model for aging in Bruch's membrane

21 January 2018

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Compositional studies of human RPE lipofuscin

21 January 2018

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21 January 2018

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Quantitative profiling of polar cationic metabolites in human cerebrospinal fluid by reversed-phase nanoliquid chromatography/mass spectrometry

21 January 2018

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An "Omics" based survey of human colon cancer

21 January 2018

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CE-MS for metabolic profiling of volume-limited urine samples: application to accelerated aging TTD mice.

21 January 2018

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Plasma protein pentosidine and carboxymethyllysine, biomarkers for age-related macular degeneration

21 January 2018

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'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data

21 January 2018

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A structure-based anatomy of the E.coli metabolome

21 January 2018

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Yeast as a navigational aid in genome analysis. 1996 Kathleen Barton-Wright Memorial Lecture.

21 January 2018

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A new rule-based algorithm for identifying metabolic markers in prostate cancer using tandem mass spectrometry.

21 January 2018

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Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium

21 January 2018

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2002 global update of available data on visual impairment: a compilation of population-based prevalence studies

21 January 2018

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Noninvasive urinary metabonomic diagnosis of human bladder cancer.

21 January 2018

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Pathway analysis of kidney cancer using proteomics and metabolic profiling

21 January 2018

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Sample preconcentration with chemical derivatization in capillary electrophoresis. Capillary as preconcentrator, microreactor and chiral selector for high-throughput metabolite screening

21 January 2018

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Serum metabolite profiling of human colorectal cancer using GC-TOFMS and UPLC-QTOFMS.

21 January 2018

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Urinary metabonomic study on colorectal cancer

21 January 2018

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Metabolomics tools for identifying biomarkers for neuropsychiatric diseases

21 January 2018

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21 January 2018

CE-MS in metabolomics

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Bacteria, yeast, worms, and flies: exploiting simple model organisms to investigate human mitochondrial diseases

21 January 2018

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Caenorhabditis elegans diet significantly affects metabolic profile, mitochondrial DNA levels, lifespan and brood size

21 January 2018

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Metabolic profiling technologies for biomarker discovery in biomedicine and drug development

21 January 2018

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Metabonomics evaluations of age-related changes in the urinary compositions of male Sprague Dawley rats and effects of data normalization methods on statistical and quantitative analysis

21 January 2018

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Mass spectrometry in aging research

21 January 2018

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Capillary electrophoresis method for the analysis of inorganic anions, organic acids, amino acids, nucleotides, carbohydrates and other anionic compounds

21 January 2018

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Clinical applications of metabolomics in oncology: a review

21 January 2018

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Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression

21 January 2018

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Improving metabolite knowledge in stable atherosclerosis patients by association and correlation of GC-MS and 1H NMR fingerprints

21 January 2018

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Derivatization of small biomolecules for optimized matrix-assisted laser desorption/ionization mass spectrometry

21 January 2018

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The global burden of cancer: priorities for prevention

21 January 2018

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Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans

21 January 2018

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An outlook on ovarian cancer and borderline ovarian tumors: focus on genomic and proteomic findings

21 January 2018

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Orthogonal projections to latent structures (O-PLS)

21 January 2018

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Practical analytical approach for the identification of biomarker candidates in prediabetic state based upon metabonomic study by ultraperformance liquid chromatography coupled to electrospray ionization time-of-flight mass spectrometry.

21 January 2018

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Matrix-suppressed laser desorption/ionisation mass spectrometry and its suitability for metabolome analyses

21 January 2018

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Biomedical application of MALDI mass spectrometry for small-molecule analysis

21 January 2018

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Plasma phospholipid metabolic profiling and biomarkers of type 2 diabetes mellitus based on high-performance liquid chromatography/electrospray mass spectrometry and multivariate statistical analysis

21 January 2018

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Oxidation of A2E results in the formation of highly reactive aldehydes and ketones.

21 January 2018

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Systems toxicology study of doxorubicin on rats using ultra performance liquid chromatography coupled with mass spectrometry based metabolomics

21 January 2018

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Urinary metabolic profiling of colorectal carcinoma based on online affinity solid phase extraction-high performance liquid chromatography and ultra performance liquid chromatography-mass spectrometry

21 January 2018

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On the Origin of Cancer Cells

21 January 2018

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Global prevalence of diabetes: estimates for the year 2000 and projections for 2030

21 January 2018

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A combined (1)H NMR and HPLC-MS-based metabonomic study of urine from obese (fa/fa) Zucker and normal Wistar-derived rats

21 January 2018

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High resolution "ultra performance" liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies.

21 January 2018

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HPLC-MS-based methods for the study of metabonomics

21 January 2018

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HMDB: a knowledgebase for the human metabolome

21 January 2018

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Metabolomic investigation of gastric cancer tissue using gas chromatography/mass spectrometry

21 January 2018

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A serum metabolomic investigation on hepatocellular carcinoma patients by chemical derivatization followed by gas chromatography/mass spectrometry

21 January 2018

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Metabonomic characterization of aging and investigation on the anti-aging effects of total flavones of Epimedium

21 January 2018

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Urinary metabonomic study of lung cancer by a fully automatic hyphenated hydrophilic interaction/RPLC-MS system

21 January 2018

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A metabonomic study of hepatitis B-induced liver cirrhosis and hepatocellular carcinoma by using RP-LC and HILIC coupled with mass spectrometry

21 January 2018

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A GC-based metabonomics investigation of type 2 diabetes by organic acids metabolic profile.

21 January 2018

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Metabonomics study of atherosclerosis rats by ultra fast liquid chromatography coupled with ion trap-time of flight mass spectrometry

21 January 2018

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Metabonomics research of diabetic nephropathy and type 2 diabetes mellitus based on UPLC-oaTOF-MS system

21 January 2018

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Metabonomic fingerprints of fasting plasma and spot urine reveal human pre-diabetic metabolic traits

21 January 2018

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Current and emerging mass-spectrometry technologies for metabolomics

21 January 2018

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21 January 2018

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A proposed metabolic strategy for monitoring disease progression in Alzheimer's disease

21 January 2018

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Directly coupled HPLC-NMR and HPLC-NMR-MS in pharmaceutical research and development

21 January 2018

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Ocular Age Pigment “A2-E”: An Unprecedented Pyridinium Bisretinoid

21 January 2018

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Application of directly coupled LC–NMR–MS to the structural elucidation of metabolites of the HIV-1 reverse-transcriptase inhibitor BW935U83

21 January 2018

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Metabonomic Investigations of Aging and Caloric Restriction in a Life-Long Dog Study

21 January 2018

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Global metabolic profiling procedures for urine using UPLC–MS

21 January 2018

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21 January 2018

Random Forests

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Astrophysics Data System

15 December 2022

https://ui.adsabs.harvard.edu/abs/2001MachL..45....5B/citations

Identifiers

DOI

10.1002/MAS.20338

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29 July 2017

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1 reference

PubMed ID

21538458