Loss of AP-2 results in downregulation of c-KIT and enhancement of melanoma tumorigenicity and metastasis. (Q33889210)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9687504%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

title

Loss of AP-2 results in downregulation of c-KIT and enhancement of melanoma tumorigenicity and metastasis (English)

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13 November 2019

2

1 reference

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13 November 2019

Michael Tainsky

4

1 reference

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13 November 2019

author name string

S Huang

1

1 reference

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13 November 2019

M Luca

3

1 reference

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13 November 2019

M Bar-Eli

5

1 reference

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13 November 2019

language of work or name

English

0 references

publication date

1 August 1998

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13 November 2019

1 reference

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13 November 2019

volume

17

1 reference

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13 November 2019

issue

15

1 reference

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13 November 2019

page(s)

4358-4369

1 reference

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Expression of interleukin-8 by human melanoma cells up-regulates MMP-2 activity and increases tumor growth and metastasis

13 November 2019

cites work

1 reference

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Convergence of MAP kinase pathways on the ternary complex factor Sap-1a

5 July 2018

1 reference

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AP2 inhibits cancer cell growth and activates p21WAF1/CIP1 expression

5 July 2018

1 reference

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Activation of transcription factor AP-2 mediates UVA radiation- and singlet oxygen-induced expression of the human intercellular adhesion molecule 1 gene

5 July 2018

1 reference

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Enforced c-KIT expression renders highly metastatic human melanoma cells susceptible to stem cell factor-induced apoptosis and inhibits their tumorigenic and metastatic potential

5 July 2018

1 reference

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Wavelength-specific induction of immediate early genes by ultraviolet radiation

5 July 2018

1 reference

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Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2

5 July 2018

1 reference

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Transcription factor AP-2 essential for cranial closure and craniofacial development

5 July 2018

1 reference

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An alternatively spliced mRNA from the AP-2 gene encodes a negative regulator of transcriptional activation by AP-2

5 July 2018

1 reference

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Microcell-mediated transfer of chromosome 6 into metastatic human C8161 melanoma cells suppresses metastasis but does not inhibit tumorigenicity

5 July 2018

1 reference

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The genomic structure of the human AP-2 transcription factor

5 July 2018

1 reference

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Bcl-2 expression in human melanocytes and melanocytic tumors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

N-ras oncogene causes AP-2 transcriptional self-interference, which leads to transformation.

5 July 2018

1 reference

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The developmentally regulated transcription factor AP-2 is involved in c-erbB-2 overexpression in human mammary carcinoma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

The melanoma differentiation-associated gene mda-6, which encodes the cyclin-dependent kinase inhibitor p21, is differentially expressed during growth, differentiation and progression in human melanoma cells.

5 July 2018

1 reference

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Wild-type p53 regulates its own transcription in a cell-type specific manner

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

Transcription factor AP-2 regulates human insulin-like growth factor binding protein-5 gene expression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

Microdissection based cloning of a translocation breakpoint in a human malignant melanoma.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

Characterization of the promoter region of the human c-kit proto-oncogene

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

Mutations and defective expression of the WAF1 p21 tumour-suppressor gene in malignant melanomas.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

Abnormalities in the CDKN2 (p16INK4/MTS-1) gene in human melanoma cells: relevance to tumor growth and metastasis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

Involvement of chromosome 6 in rearrangements in human malignant melanoma cell lines

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

An RNA polymerase II transcription factor binds to an upstream element in the adenovirus major late promoter.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

Upstream promoter element of the human metallothionein-IIA gene can act like an enhancer element

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

Effect of ultraviolet-B radiation on the in vivo growth of murine melanoma cells.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

Positive and negative regulation of transcription in vitro: enhancer-binding protein AP-2 is inhibited by SV40 T antigen

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

Identification of a recurring translocation site involving chromosome 6 in human malignant melanoma.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

An AP-2 element acts synergistically with the cyclic AMP- and phorbol ester-inducible enhancer of the human proenkephalin gene

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

Regulation of transcription factor AP-2 by the morphogen retinoic acid and by second messengers.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice--evidence for an impaired c-kit kinase in mutant mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

Interaction of cellular proteins with the human T-cell leukemia virus type I transcriptional control region. Purification of cellular proteins that bind the 21-base pair repeat elements.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

Tumorigenicity in human melanoma cell lines controlled by introduction of human chromosome 6.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

Characterization of a dimerization motif in AP-2 and its function in heterologous DNA-binding proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

Localization of the gene for the DNA-binding protein AP-2 to human chromosome 6p22.3-pter

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

Deletion of the c-kit protooncogene in the human developmental defect piebald trait

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

Mutation of the KIT (mast/stem cell growth factor receptor) protooncogene in human piebaldism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

Transcription factor AP2 and its role in epidermal-specific gene expression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

In utero manipulation of coat color formation by a monoclonal anti-c-kit antibody: two distinct waves of c-kit-dependency during melanocyte development.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

Developmental expression of c-kit, a proto-oncogene encoded by the W locus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

Interaction of AP-1-, AP-2-, and Sp1-like proteins with two distinct sites in the upstream regulatory region of the plasminogen activator inhibitor-1 gene mediates the phorbol 12-myristate 13-acetate response

5 July 2018

1 reference

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Identification of a 10-base pair protein binding site in the promoter of the hamster H3.2 gene required for the S phase dependent increase in transcription and its interaction with a Jun-like nuclear factor.

5 July 2018

1 reference

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Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

5 July 2018

1 reference

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Progression of human cutaneous melanoma is associated with loss of expression of c-kit proto-oncogene receptor.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

Human piebald trait resulting from a dominant negative mutant allele of the c-kit membrane receptor gene

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

Loss of AP-2 results in up-regulation of MCAM/MUC18 and an increase in tumor growth and metastasis of human melanoma cells.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

Direct correlation between MUC18 expression and metastatic potential of human melanoma cells.

29 October 2018

1 reference

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Techniques of cutaneous examination for the detection of skin cancer

29 October 2018

1 reference

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The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1170769

KIT ligand (mast cell growth factor) inhibits the growth of KIT-expressing melanoma cells

29 October 2018

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12 December 2020

Expression of gp185HER-2 in human cutaneous melanoma: implications for experimental immunotherapeutics

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12 December 2020

Terminal differentiation and apoptosis in experimental lung metastases of human osteogenic sarcoma cells by wild type p53

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12 December 2020

Linkage analysis in familial melanoma kindreds to markers on chromosome 6p

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12 December 2020

Intertumoral heterogeneity of receptor-tyrosine kinases expression in human melanoma cell lines with different metastatic capabilities

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12 December 2020

Loss of heterozygosity in sporadic primary cutaneous melanoma

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12 December 2020

Correlation of growth capacity of human tumor cells in hard agarose with their in vivo proliferative capacity at specific metastatic sites

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12 December 2020

The Dominant W 42 Spotting Phenotype Results from a Missense Mutation in the c- kit Receptor Kinase

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12 December 2020

Loss of c-kit expression in cultured melanoma cells

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12 December 2020

Ultraviolet B irradiation promotes tumorigenic and metastatic properties in primary cutaneous melanoma via induction of interleukin 8

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12 December 2020

Cadherin expression in melanocytic naevi and malignant melanomas

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12 December 2020

Bcl-2 expression in malignant melanoma and its prognostic significance

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12 December 2020

Expression of MCAM/MUC18 by human melanoma cells leads to increased tumor growth and metastasis

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12 December 2020

Dominant-negative CREB inhibits tumor growth and metastasis of human melanoma cells

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12 December 2020

Molecular mechanisms of melanoma metastasis

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12 December 2020

Epidemiology of pre-invasive and invasive malignant melanoma in Western Australia

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12 December 2020

A human melanoma line heterogeneous with respect to metastatic capacity in athymic nude mice

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12 December 2020

The putative melanoma tumor-suppressor gene on human chromosome 6q

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12 December 2020

Identifiers

DOI

10.1093/EMBOJ/17.15.4358

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9687504%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9687504%20AND%20SRC:MED&resulttype=core&format=json

13 November 2019

1 reference