Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc. (Q33890400)

29 July 2017

title

Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc. (English)

1 reference

29 July 2017

1 reference

S E Salghetti

1

1 reference

29 July 2017

S Y Kim

series ordinal

2

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29 July 2017

W P Tansey

series ordinal

3

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29 July 2017

language of work or name

English

0 references

publication date

1 February 1999

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29 July 2017

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29 July 2017

volume

18

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29 July 2017

issue

3

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29 July 2017

page(s)

717-726

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myc boxes, which are conserved in myc family proteins, are signals for protein degradation via the proteasome

29 July 2017

cites work

1 reference

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5 July 2018

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5 July 2018

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c-Raf kinase binds to N-terminal domain of c-Myc

5 July 2018

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5 July 2018

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Regulation of E2F through ubiquitin-proteasome-dependent degradation: stabilization by the pRB tumor suppressor protein

5 July 2018

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Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases

5 July 2018

1 reference

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Ubiquitin-dependent protein degradation

5 July 2018

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Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins

5 July 2018

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The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway

5 July 2018

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Radical mutations reveal TATA-box binding protein surfaces required for activated transcription in vivo.

5 July 2018

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Cdc53 targets phosphorylated G1 cyclins for degradation by the ubiquitin proteolytic pathway

5 July 2018

1 reference

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Proteins of the Myc network: essential regulators of cell growth and differentiation.

5 July 2018

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Cdc25 cell-cycle phosphatase as a target of c-myc

5 July 2018

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5 July 2018

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Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MAT alpha 2 repressor

5 July 2018

1 reference

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The PRE4 gene codes for a subunit of the yeast proteasome necessary for peptidylglutamyl-peptide-hydrolyzing activity. Mutations link the proteasome to stress- and ubiquitin-dependent proteolysis.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171164

The ornithine decarboxylase gene is a transcriptional target of c-Myc

5 July 2018

1 reference

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Repression of cyclin D1: a novel function of MYC

5 July 2018

1 reference

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Accumulation of p53 in a mutant cell line defective in the ubiquitin pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171164

Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171164

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171164

Interaction of c-Myc with the pRb-related protein p107 results in inhibition of c-Myc-mediated transactivation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171164

Hierarchical phosphorylation at N-terminal transformation-sensitive sites in c-Myc protein is regulated by mitogens and in mitosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171164

A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171164

p34Cdc28-mediated control of Cln3 cyclin degradation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171164

Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171164

A link between increased transforming activity of lymphoma-derived MYC mutant alleles, their defective regulation by p107, and altered phosphorylation of the c-Myc transactivation domain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171164

Degradation of c-Fos by the 26S proteasome is accelerated by c-Jun and multiple protein kinases

5 July 2018

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Proteins encoded by the human c-myc oncogene: differential expression in neoplastic cells

5 July 2018

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Quail embryo fibroblasts transformed by four v-myc-containing virus isolates show enhanced proliferation but are non tumorigenic

5 July 2018

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Regulation of the Cellular p53 Tumor Antigen in Teratocarcinoma Cells and Their Differentiated Progeny

5 July 2018

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Quantitation of a 55K Cellular Protein: Similar Amount and Instability in Normal and Malignant Mouse Cells

5 July 2018

1 reference

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Rapid and efficient site-specific mutagenesis without phenotypic selection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171164

Differential transcriptional activation by Oct-1 and Oct-2: interdependent activation domains induce Oct-2 phosphorylation

5 July 2018

1 reference

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An amino-terminal c-myc domain required for neoplastic transformation activates transcription

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171164

Control of c-myc regulation in normal and neoplastic cells.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171164

Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171164

Degradation of nuclear oncoproteins by the ubiquitin system in vitro

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171164

A phosphorylation site located in the NH2-terminal domain of c-Myc increases transactivation of gene expression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171164

Promoter-selective activation domains in Oct-1 and Oct-2 direct differential activation of an snRNA and mRNA promoter

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171164

Targeted degradation of c-Fos, but not v-Fos, by a phosphorylation-dependent signal on c-Jun

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171164

Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171164

The role of protein stability in the cell cycle and cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171164

Site-specific modulation of c-Myc cotransformation by residues phosphorylated in vivo.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171164

Phosphorylation sites mapping in the N-terminal domain of c-myc modulate its transforming potential.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171164

Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171164

Basal promoter elements as a selective determinant of transcriptional activator function

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171164

Viral and cellular fos proteins: A comparative analysis

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/9927431

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mutations in the coding region of c-MYC in AIDS-associated and other aggressive lymphomas

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/9927431

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/EMBOJ/18.3.717

1 reference

29 July 2017

1 reference

29 July 2017

1 reference