The lupus susceptibility locus Sle1 breaches peripheral B cell tolerance at the antibody-forming cell and germinal center checkpoints (Q33890686)

29 July 2017

title

The lupus susceptibility locus Sle1 breaches peripheral B cell tolerance at the antibody-forming cell and germinal center checkpoints (English)

1 reference

29 July 2017

1 reference

Raja Vuyyuru

1

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29 July 2017

Chandra Mohan

series ordinal

2

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29 July 2017

Tim Manser

series ordinal

3

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29 July 2017

Ziaur S M Rahman

series ordinal

4

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29 July 2017

language of work or name

English

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publication date

14 October 2009

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29 July 2017

published in

Journal of Immunology

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29 July 2017

volume

183

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29 July 2017

issue

9

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29 July 2017

page(s)

5716-5727

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Influence of Fas on the regulation of the response of an anti-nuclear antigen B cell clonotype to foreign antigen

29 July 2017

cites work

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5 July 2018

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A checkpoint for autoreactivity in human IgM+ memory B cell development

5 July 2018

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Germinal center exclusion of autoreactive B cells is defective in human systemic lupus erythematosus.

5 July 2018

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Defective B cell tolerance checkpoints in systemic lupus erythematosus

5 July 2018

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Direct repression of prdm1 by Bcl-6 inhibits plasmacytic differentiation

5 July 2018

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Normal induction but attenuated progression of germinal center responses in BAFF and BAFF-R signaling-deficient mice

5 July 2018

1 reference

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Regulatory mechanisms that determine the development and function of plasma cells

5 July 2018

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Delineating the genetic basis of systemic lupus erythematosus

5 July 2018

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The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes

5 July 2018

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Immune inhibitory receptors

5 July 2018

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Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains.

5 July 2018

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Genetic dissection of systemic lupus erythematosus

5 July 2018

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Severe attenuation of the B cell immune response in Msh2-deficient mice

5 July 2018

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The dynamic structure of the germinal center.

5 July 2018

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Genetic dissection of SLE pathogenesis. Sle1 on murine chromosome 1 leads to a selective loss of tolerance to H2A/H2B/DNA subnucleosomes

5 July 2018

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Regulation of anti-double-stranded DNA B cells in nonautoimmune mice: localization to the T-B interface of the splenic follicle

5 July 2018

1 reference

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The "clonal selection hypothesis" and current concepts of B cell tolerance

5 July 2018

1 reference

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BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor

5 July 2018

1 reference

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Receptor editing: an approach by autoreactive B cells to escape tolerance

5 July 2018

1 reference

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Receptor editing in self-reactive bone marrow B cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879885

5 July 2018

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Random mutagenesis of two complementarity determining region amino acids yields an unexpectedly high frequency of antibodies with increased affinity for both cognate antigen and autoantigen

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879885

Self-tolerance checkpoints in B lymphocyte development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879885

A lifetime's flirtation with repertoire purging

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879885

The role of somatic mutation in the pathogenic anti-DNA response

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879885

Quantitatively reduced participation of anti-nuclear antigen B cells that down-regulate B cell receptor during primary development in the germinal center/memory B cell response to foreign antigen

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879885

Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879885

B cells expressing Bcl-2 and a signaling-impaired BAFF-specific receptor fail to mature and are deficient in the formation of lymphoid follicles and germinal centers

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879885

Progressive surface B cell antigen receptor down-regulation accompanies efficient development of antinuclear antigen B cells to mature, follicular phenotype

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879885

Low-affinity anti-Smith antigen B cells are regulated by anergy as opposed to developmental arrest or differentiation to B-1.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879885

BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879885

Autoreactive B cell regulation: peripheral induction of developmental arrest by lupus-associated autoantigens.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879885

The site and stage of anti-DNA B-cell deletion.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879885

Cross-reactive antibodies have both protective and pathogenic potential

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879885

The inhibitory Fcγ receptor modulates autoimmunity by limiting the accumulation of immunoglobulin G+ anti-DNA plasma cells

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2879885

Polymorphisms in IgG Fc receptor IIB regulatory regions associated with autoimmune susceptibility

29 October 2018

1 reference

12 December 2020

The major murine systemic lupus erythematosus susceptibility locus Sle1 results in abnormal functions of both B and T cells

1 reference

12 December 2020

Evolution of autoantibody responses via somatic hypermutation outside of germinal centers

1 reference

12 December 2020

Dominant, hierarchical induction of peripheral tolerance during foreign antigen-driven B cell development

1 reference

12 December 2020

Germinal center checkpoints in B cell tolerance in 3H9 transgenic mice

1 reference

12 December 2020

The genetic basis of antibody production: The dominant anti-arsonate idiotype response of the strain a mouse

1 reference

12 December 2020

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

1 reference

12 December 2020

A substantial proportion of the adult BALB/c available B cell repertoire consists of multireactive B cells

1 reference

12 December 2020

Polygenic control of susceptibility to murine systemic lupus erythematosus

1 reference

12 December 2020

Functional dissection of systemic lupus erythematosus using congenic mouse strains

1 reference

12 December 2020

Genetic dissection of systemic lupus erythematosus pathogenesis: Sle2 on murine chromosome 4 leads to B cell hyperactivity

1 reference

12 December 2020

Genetic dissection of SLE pathogenesis: adoptive transfer of Sle1 mediates the loss of tolerance by bone marrow-derived B cells

1 reference

12 December 2020

Genetic dissection of Sle pathogenesis: Sle3 on murine chromosome 7 impacts T cell activation, differentiation, and cell death

1 reference

12 December 2020

Expression of the autoimmune Fcgr2b NZW allele fails to be upregulated in germinal center B cells and is associated with increased IgG production

1 reference

12 December 2020

Murine lupus susceptibility locus Sle1a controls regulatory T cell number and function through multiple mechanisms

1 reference

12 December 2020

Epistatic modifiers of autoimmunity in a murine model of lupus nephritis

1 reference

12 December 2020

Genetically determined aberrant down-regulation of FcgammaRIIB1 in germinal center B cells associated with hyper-IgG and IgG autoantibodies in murine systemic lupus erythematosus

1 reference

12 December 2020

Antinuclear antigen B cells that down-regulate surface B cell receptor during development to mature, follicular phenotype do not display features of anergy in vitro

1 reference

12 December 2020

Genetic determination of T cell help in loss of tolerance to nuclear antigens

1 reference

12 December 2020

Failed up-regulation of the inhibitory IgG Fc receptor Fc gamma RIIB on germinal center B cells in autoimmune-prone mice is not associated with deletion polymorphisms in the promoter region of the Fc gamma RIIB gene

1 reference

12 December 2020

B cell tolerance checkpoints that restrict pathways of antigen-driven differentiation

1 reference

12 December 2020

FcgammaRIIB regulates autoreactive primary antibody-forming cell, but not germinal center B cell, activity

1 reference

12 December 2020

Identifiers

DOI

10.4049/JIMMUNOL.0804215

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29 July 2017

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29 July 2017

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