Rational design of aggregation-resistant bioactive peptides: reengineering human calcitonin (Q33895725)

29 July 2017

Rational design of aggregation-resistant bioactive peptides: reengineering human calcitonin (English)

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29 July 2017

5

Christopher M Dobson

1 reference

29 July 2017

Susan B Fowler

1

1 reference

29 July 2017

Stephen Poon

2

1 reference

29 July 2017

Roman Muff

3

1 reference

29 July 2017

Fabrizio Chiti

4

1 reference

29 July 2017

Jesús Zurdo

6

1 reference

29 July 2017

language of work or name

English

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publication date

8 July 2005

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Proceedings of the National Academy of Sciences of the United States of America

29 July 2017

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29 July 2017

102

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29 July 2017

29

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29 July 2017

10105-10110

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Prediction of "aggregation-prone" and "aggregation-susceptible" regions in proteins associated with neurodegenerative diseases

29 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174920

Polypeptide models to understand misfolding and amyloidogenesis and their relevance in protein design and therapeutics.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174920

Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174920

A highly amyloidogenic region of hen lysozyme

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174920

The role of aromaticity, exposed surface, and dipole moment in determining protein aggregation rates

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174920

Short amino acid stretches can mediate amyloid formation in globular proteins: the Src homology 3 (SH3) case

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174920

Physical stability of proteins in aqueous solution: mechanism and driving forces in nonnative protein aggregation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174920

Calcitonin for osteoporosis and bone pain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174920

Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific Activity

5 July 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174920

5 July 2018

https://api.crossref.org/works/10.1073%2FPNAS.0501215102

Rationalization of the effects of mutations on peptide and protein aggregation rates.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174920

De novo designed peptide-based amyloid fibrils

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174920

Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174920

Interaction of calcitonin-gene-related peptide with its receptors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174920

Bioequivalence and the immunogenicity of biopharmaceuticals

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174920

Diagnosis and treatment of Paget's disease of bone

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174920

International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174920

Forty years of calcitonin--where are we now? A tribute to the work of Iain Macintyre, FRS.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174920

The new pre-preclinical paradigm: compound optimization in early and late phase drug discovery

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174920

Channel formation by salmon and human calcitonin in black lipid membranes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174920

Dependence on solution conditions of aggregation and amyloid formation by an SH3 domain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174920

Protein engineering as a strategy to avoid formation of amyloid fibrils

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174920

Anaphylaxis to calcitonin.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174920

Calcitonin receptor mRNA in mononuclear leucocytes from postmenopausal women: decrease during osteoporosis and link to bone markers with specific isoform involvement

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174920

Nature disfavors sequences of alternating polar and non-polar amino acids: implications for amyloidogenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174920

Translocation of human calcitonin in respiratory nasal epithelium is associated with self-assembly in lipid membrane.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174920

Toward understanding insulin fibrillation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174920

Clinical significance of antibodies against calcitonin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174920

The structure and mechanism of formation of human calcitonin fibrils

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174920

The development of stable protein formulations: a close look at protein aggregation, deamidation, and oxidation.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174920

Amyloid peptides are toxic via a common oxidative mechanism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174920

Formation of neutralizing antibodies during intranasal synthetic salmon calcitonin treatment of Paget's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174920

Formation of neutralizing antibodies during intranasal synthetic salmon calcitonin treatment of postmenopausal osteoporosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174920

Characterization of amyloid fibril proteins from medullary carcinoma of the thyroid

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174920

Amyloid fibril formation by pentapeptide and tetrapeptide fragments of human calcitonin

5 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0501215102

Prediction of amyloid fibril-forming proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0501215102

Elucidating the folding problem of helical peptides using empirical parameters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0501215102

Calcitonin-induced anorexia in rats: a structure-activity study by intraventricular injections.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1174920

Prediction of the Absolute Aggregation Rates of Amyloidogenic Polypeptide Chains

29 October 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0501215102

Enhanced potency of human calcitonin when fibrillation is avoided

21 January 2018

1 reference

12 December 2020

Chloramine-T in radiolabeling techniques. II. A nondestructive method for radiolabeling biomolecules by halogenation

1 reference

12 December 2020

Calcitonin and chromogranin A localization in medullary carcinoma of the thyroid by immunoelectron microscopy

1 reference

12 December 2020

Recombinant human IL-2 is cytotoxic to oligodendrocytes after in vitro self aggregation

1 reference

12 December 2020

The role of G protein activation in the toxicity of amyloidogenic Abeta-(1-40), Abeta-(25-35), and bovine calcitonin

1 reference

12 December 2020

Coexistence of novel amylin-binding sites with calcitonin receptors in human breast carcinoma MCF-7 cells

1 reference

12 December 2020

Protein aggregates seem to play a key role among the parameters influencing the antigenicity of interferon alpha (IFN-alpha) in normal and transgenic mice

1 reference

12 December 2020

Effect of Calcitonin on Bone Lesions in Chronic Dialysis Patients

1 reference

12 December 2020

1 reference

12 December 2020

Conformationally constrained human calcitonin (hCt) analogues reveal a critical role of sequence 17-21 for the oligomerization state and bioactivity of hCt

1 reference

12 December 2020

Allergy to calcitonin

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0501215102

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29 July 2017

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29 July 2017

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