Xenobiotic-metabolizing cytochromes P450 convert prostaglandin endoperoxide to hydroxyheptadecatrienoic acid and the mutagen, malondialdehyde. (Q33898260)

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English	Xenobiotic-metabolizing cytochromes P450 convert prostaglandin endoperoxide to hydroxyheptadecatrienoic acid and the mutagen, malondialdehyde.	scientific article

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5 November 2019

Xenobiotic-metabolizing cytochromes P450 convert prostaglandin endoperoxide to hydroxyheptadecatrienoic acid and the mutagen, malondialdehyde (English)

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5 November 2019

John P Plastaras

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5 November 2019

F. Peter Guengerich

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F P Guengerich

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5 November 2019

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D W Nebert

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5 November 2019

L J Marnett

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1 April 2000

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5 November 2019

Journal of Biological Chemistry

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5 November 2019

275

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5 November 2019

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5 November 2019

11784-11790

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5 November 2019

Prostaglandins from tumours of human large bowel

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A hypothesis: nonsteroidal anti-inflammatory drugs reduce the incidence of large-bowel cancer.

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Aspirin use and reduced risk of fatal colon cancer

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Relationship between blood plasma prostaglandin E2 and liver and lung metastases in colorectal cancer

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Enhanced secretion of prostaglandin E2 by tissue-fixed macrophages in colonic carcinoma

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Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

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The relationship between cyclooxygenase-2 expression and colorectal cancer.

1 reference

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21 January 2018

Unequivocal demonstration that malondialdehyde is a mutagen

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21 January 2018

Mutagenicity and cytotoxicity of malonaldehyde in mammalian cells

1 reference

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21 January 2018

Investigation of the adducts formed by reaction of malondialdehyde with adenosine

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21 January 2018

Naturally occurring carbonyl compounds are mutagens in Salmonella tester strain TA104.

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Identification of adducts formed by reaction of guanine nucleosides with malondialdehyde and structurally related aldehydes

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Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets

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21 January 2018

Conversion of prostaglandin endoperoxides to C17-hydroxy acids catalyzed by human platelet thromboxane synthase

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21 January 2018

Kinetic studies on the conversion of prostaglandin endoperoxide PGH2 by thromboxane synthase

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Determinants of steroid hormone bioavailability

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The immunohistochemical localization of drug-metabolizing enzymes in prostate cancer.

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Cytochrome P450 expression in oesophageal cancer

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Expression of CYP1A1 gene in patients with lung cancer: evidence for cigarette smoke-induced gene expression in normal lung tissue and for altered gene regulation in primary pulmonary carcinomas.

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Xenobiotic metabolising enzyme expression in colonic neoplasia

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Effects of diet and ethanol on the expression and localization of cytochromes P450 2E1 and P450 2C7 in the colon of male rats

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Sustained increase in intracellular free calcium and activation of cyclooxygenase-2 expression in mouse hepatoma cells treated with dioxin

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Isolation and Structure of Two Prostaglandin Endoperoxides That Cause Platelet Aggregation

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21 January 2018

Detection and Isolation of an Endoperoxide Intermediate in Prostaglandin Biosynthesis

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Expression of modified human cytochrome P450 3A4 in Escherichia coli and purification and reconstitution of the enzyme.

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21 January 2018

Expression of modified human cytochrome P450 1A2 in Escherichia coli: stabilization, purification, spectral characterization, and catalytic activities of the enzyme.

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Expression of modified human cytochrome P450 2E1 in Escherichia coli, purification, and spectral and catalytic properties.

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A simple and rapid method for the purification of cytochrome P-450 (form LM4).

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21 January 2018

Products, kinetics, and substrate specificity of homogeneous thromboxane synthase from human platelets: development of a novel enzyme assay

1 reference

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21 January 2018

Identification of thromboxane A2 synthase active site residues by molecular modeling-guided site-directed mutagenesis

1 reference

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21 January 2018

Identifiers

10.1074/JBC.275.16.11784

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10766802%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10766802%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

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