Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype. (Q33902217)

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6 November 2019

title

Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype (English)

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6 November 2019

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6

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6 November 2019

Owain W. Howell

16

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6 November 2019

author name string

McKernan RM

1

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Rosahl TW

2

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Reynolds DS

3

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Sur C

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Wafford KA

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Farrar S

7

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Myers J

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Cook G

9

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Ferris P

10

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Garrett L

11

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Bristow L

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Marshall G

13

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Macaulay A

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Brown N

15

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Moore KW

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Carling RW

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Street LJ

19

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Castro JL

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Ragan CI

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Dawson GR

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Whiting PJ

23

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language of work or name

English

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publication date

1 June 2000

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volume

3

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issue

6

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6 November 2019

page(s)

587-592

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https://scigraph.springernature.com/pub.10.1038/75761

6 November 2019

exact match

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cites work

Type I and type II GABAA-benzodiazepine receptors produced in transfected cells

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7 January 2021

Gamma-aminobutyric acidA receptor alpha 5-subunit creates novel type II benzodiazepine receptor pharmacology.

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7 January 2021

Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes.

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Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

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Short-term synaptic plasticity is altered in mice lacking synapsin I.

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Essential functions of synapsins I and II in synaptic vesicle regulation

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7 January 2021

A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells

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7 January 2021

GABAA-receptor heterogeneity in the adult rat brain: differential regional and cellular distribution of seven major subunits

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7 January 2021

The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon

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7 January 2021

GABAA receptor subtypes immunopurified from rat brain with α subunit-specific antibodies have unique pharmacological properties

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7 January 2021

Cerebellar GABAA receptor selective for a behavioural alcohol antagonist

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7 January 2021

Cloning, pharmacological characteristics and expression pattern of the rat GABAA receptor alpha 4 subunit

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7 January 2021

Animal models for the study of anti-anxiety agents: a review

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7 January 2021

Use of the elevated plus maze in the search for novel anxiolytic agents

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7 January 2021

Stable expression of mammalian type A gamma-aminobutyric acid receptors in mouse cells: demonstration of functional assembly of benzodiazepine-responsive sites

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7 January 2021

Comparison of benzodiazepine (BZ) receptor agonists in two rodent activity tests

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7 January 2021

Regional differences in the inhibition of mouse in vivo [3H]Ro 15-1788 binding reflect selectivity for alpha 1 versus alpha 2 and alpha 3 subunit-containing GABAA receptors.

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7 January 2021

Five subtypes of type A gamma-aminobutyric acid receptors identified in neurons by double and triple immunofluorescence staining with subunit-specific antibodies

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7 January 2021

Neuron-specific expression of GABAA-receptor subtypes: differential association of the alpha 1- and alpha 3-subunits with serotonergic and GABAergic neurons

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7 January 2021

Manipulation of transgenes by site-specific recombination: use of Cre recombinase

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7 January 2021

Autoradiographic localization of alpha5 subunit-containing GABAA receptors in rat brain

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7 January 2021

Preferential coassembly of alpha4 and delta subunits of the gamma-aminobutyric acidA receptor in rat thalamus.

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7 January 2021

The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum.

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7 January 2021

On the elevated plus-maze the anxiolytic-like effects of the 5-HT(1A) agonist, 8-OH-DPAT, but not the anxiogenic-like effects of the 5-HT(1A) partial agonist, buspirone, are blocked by the 5-HT1A antagonist, WAY 100635.

1 reference

7 January 2021

Towards better benzodiazepines.

1 reference

7 January 2021

Neuronally restricted RNA splicing regulates the expression of a novel GABAA receptor subunit conferring atypical functional properties [corrected; erratum to be published]

1 reference

7 January 2021

Anxiolytic effects of buspirone and gepirone in the fear-potentiated startle paradigm

1 reference

7 January 2021

Identifiers

DOI

10.1038/75761

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10816315%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

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