Progressive Staging of Pilot Studies to Improve Phase III Trials for Motor Interventions (Q33904274)

29 July 2017

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title

Progressive Staging of Pilot Studies to Improve Phase III Trials for Motor Interventions (English)

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29 July 2017

main subject

phase III clinical trial

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1

Bruce H Dobkin

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29 July 2017

publication date

1 March 2009

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Neurorehabilitation and Neural Repair

29 July 2017

published in

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29 July 2017

volume

23

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29 July 2017

issue

3

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29 July 2017

page(s)

197-206

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The future of restorative neurosciences in stroke: driving the translational research pipeline from basic science to rehabilitation of people after stroke

29 July 2017

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5 July 2018

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Constraint-induced movement therapy results in increased motor map area in subjects 3 to 9 months after stroke.

5 July 2018

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5 July 2018

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Treadmill exercise activates subcortical neural networks and improves walking after stroke: a randomized controlled trial

5 July 2018

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A novel, efficient, randomized selection trial comparing combinations of drug therapy for ALS.

5 July 2018

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Locomotor training for walking after spinal cord injury

5 July 2018

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Interim futility analysis with intermediate endpoints

5 July 2018

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The science of research: the principles underlying the discovery of cognitive and other biological mechanisms

5 July 2018

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Training and exercise to drive poststroke recovery

5 July 2018

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Guidelines for reporting an fMRI study

5 July 2018

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Intensive sensorimotor arm training mediated by therapist or robot improves hemiparesis in patients with chronic stroke

5 July 2018

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Motor skill training, but not voluntary exercise, improves skilled reaching after unilateral ischemic lesions of the sensorimotor cortex in rats

5 July 2018

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Informing dose-finding studies of repetitive transcranial magnetic stimulation to enhance motor function: a qualitative systematic review

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099048

Protocol for the Locomotor Experience Applied Post-stroke (LEAPS) trial: a randomized controlled trial

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099048

Electromechanical-assisted training for walking after stroke

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099048

Effects of robot-assisted therapy on upper limb recovery after stroke: a systematic review

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099048

Looking in the rear view mirror when conversing with back seat drivers: the EXCITE trial revisited.

5 July 2018

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Curiosity and cure: translational research strategies for neural repair-mediated rehabilitation

5 July 2018

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Transcranial magnetic stimulation and muscle contraction to enhance stroke recovery: a randomized proof-of-principle and feasibility investigation

5 July 2018

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Comparison of speeds used for the 15.2-meter and 6-minute walks over the year after an incomplete spinal cord injury: the SCILT Trial

5 July 2018

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Evolution of FMRI activation in the perilesional primary motor cortex and cerebellum with rehabilitation training-related motor gains after stroke: a pilot study

5 July 2018

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Locomotor training remodels fMRI sensorimotor cortical activations in children after cerebral hemispherectomy.

5 July 2018

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Plasticity of spinal centers in spinal cord injury patients: new concepts for gait evaluation and training

5 July 2018

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The evolution of walking-related outcomes over the first 12 weeks of rehabilitation for incomplete traumatic spinal cord injury: the multicenter randomized Spinal Cord Injury Locomotor Trial

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099048

Constraint-induced movement therapy during early stroke rehabilitation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099048

Confounders in rehabilitation trials of task-oriented training: lessons from the designs of the EXCITE and SCILT multicenter trials

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099048

Effect of constraint-induced movement therapy on upper extremity function 3 to 9 months after stroke: the EXCITE randomized clinical trial

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099048

Weight-supported treadmill vs over-ground training for walking after acute incomplete SCI.

5 July 2018

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Rehabilitation and functional neuroimaging dose-response trajectories for clinical trials

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099048

Treadmill training and body weight support for walking after stroke

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099048

Clinical practice. Rehabilitation after stroke

5 July 2018

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Ankle dorsiflexion as an fMRI paradigm to assay motor control for walking during rehabilitation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099048

Methods for a Randomized Trial of Weight-Supported Treadmill Training Versus Conventional Training for Walking During Inpatient Rehabilitation after Incomplete Traumatic Spinal Cord Injury

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099048

Methods for a multisite randomized trial to investigate the effect of constraint-induced movement therapy in improving upper extremity function among adults recovering from a cerebrovascular stroke

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099048

Locomotor training in neurorehabilitation: emerging rehabilitation concepts

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099048

The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099048

Limitations of randomized clinical trials. Proposed alternative designs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099048

Design for the everest randomized trial of cortical stimulation and rehabilitation for arm function following stroke

5 July 2018

1 reference

https://api.crossref.org/works/10.1177%2F1545968309331863

Step training with body weight support: effect of treadmill speed and practice paradigms on poststroke locomotor recovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1545968309331863

Speed and temporal-distance adaptations during treadmill and overground walking following stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1545968309331863

Combined use of body weight support, functional electric stimulation, and treadmill training to improve walking ability in individuals with chronic incomplete spinal cord injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1545968309331863

Comparison of partial body weight-supported treadmill gait training versus aggressive bracing assisted walking post stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1545968309331863

Swing phase resistance enhances flexor muscle activity during treadmill locomotion in incomplete spinal cord injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1545968309331863

The influence of treadmill inclination on the gait of ambulatory hemiparetic subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1545968309331863

Prospective, blinded, randomized crossover study of gait rehabilitation in stroke patients using the Lokomat gait orthosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1545968309331863

An electromechanical gait trainer for restoration of gait in hemiparetic stroke patients: preliminary results.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1545968309331863

Changes in supraspinal activation patterns following robotic locomotor therapy in motor-incomplete spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1545968309331863

Functional outcomes can vary by dose: learning-based sensorimotor training for patients stable poststroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1545968309331863

Recovery of gait after stroke: what changes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1545968309331863

Improving gait in multiple sclerosis using robot-assisted, body weight supported treadmill training.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1545968309331863

Multicenter randomized clinical trial evaluating the effectiveness of the Lokomat in subacute stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1545968309331863

An accelerometry-based comparison of 2 robotic assistive devices for treadmill training of gait

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1545968309331863

Reliability and validity of bilateral thigh and foot accelerometry measures of walking in healthy and hemiparetic subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1545968309331863

Motor cortex activation during treatment may predict therapeutic gains in paretic hand function after stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1545968309331863

Constraint-induced therapy versus dose-matched control intervention to improve motor ability, basic/extended daily functions, and quality of life in stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1545968309331863

Assessing mechanisms of recovery during robot-aided neurorehabilitation of the upper limb

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1545968309331863

Robot-based hand motor therapy after stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1545968309331863

The effect of the GENTLE/s robot-mediated therapy system on arm function after stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1545968309331863

Influence of combined afferent stimulation and task-specific training following stroke: a pilot randomized controlled trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1545968309331863

Cortical and spinal excitability changes after robotic gait training in healthy participants

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1545968309331863

Bilateral arm training with rhythmic auditory cueing in chronic stroke: not always efficacious

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1545968309331863

Interpreting rehabilitation outcome measurements.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1545968309331863

Bayesian predictive power for interim adaptation in seamless phase II/III trials where the endpoint is survival up to some specified timepoint.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1545968309331863

Measurement Error in Functional Balance and Mobility Tests for People With Stroke: What Are the Sources of Error and What Is the Best Way to Minimize Error?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1545968309331863

Inter-individual variability in the capacity for motor recovery after ischemic stroke

21 January 2018

1 reference

12 December 2020

Motor Imagery to Enhance Recovery After Subcortical Stroke: Who Might Benefit, Daily Dose, and Potential Effects

1 reference

12 December 2020

Psychometric comparisons of 2 versions of the Fugl-Meyer Motor Scale and 2 versions of the Stroke Rehabilitation Assessment of Movement

1 reference

12 December 2020

Estimating the minimal clinically important difference of the Stroke Rehabilitation Assessment of Movement measure

1 reference

12 December 2020

Walking during daily life can be validly and responsively assessed in subjects with a spinal cord injury

1 reference

12 December 2020

Hemiparetic gait parameters in overground versus treadmill walking

1 reference

12 December 2020

Randomized Clinical Trial of Therapeutic Exercise in Subacute Stroke

1 reference

12 December 2020

Gains in Distance Walking in a 3-Month Follow-Up Poststroke: What Changes?

1 reference

12 December 2020

Intensity of leg and arm training after primary middle-cerebral-artery stroke: a randomised trial

1 reference

12 December 2020

Development of a Schedule of Current Physiotherapy Treatment Used to Improve Movement Control and Functional Use of the Lower Limb after Stroke: A Precursor to a Clinical Trial

1 reference

12 December 2020

Resistance training with creatine monohydrate improves upper-body strength in patients with Parkinson disease: a randomized trial

1 reference

12 December 2020

Effects of Stroke Severity and Training Duration on Locomotor Recovery After Stroke: A Pilot Study

1 reference

12 December 2020

Assessment and Training in a 3-Dimensional Virtual Environment With Haptics: A Report on 5 Cases of Motor Rehabilitation in the Chronic Stage After Stroke

1 reference

12 December 2020

Concepts of motor learning applied to a rehabilitation protocol using biofeedback to improve gait in a chronic stroke patient: an A-B system study with multiple gait analyses

1 reference

12 December 2020

Establishing the Minimal Clinically Important Difference of the Barthel Index in Stroke Patients

1 reference

12 December 2020

Assessment of walking speed and distance in subjects with an incomplete spinal cord injury

1 reference

12 December 2020

Learning implicitly: effects of task and severity after stroke

1 reference

12 December 2020

Identifiers

DOI

10.1177/1545968309331863

1 reference

29 July 2017

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29 July 2017

1 reference