Akt1 in the cardiovascular system: friend or foe? (Q33905832)

29 July 2017

Akt1 in the cardiovascular system: friend or foe? (English)

1 reference

29 July 2017

1 reference

Brian T O'Neill

1

1 reference

PubMed ID

16075047

29 July 2017

E Dale Abel

series ordinal

2

1 reference

PubMed ID

16075047

29 July 2017

language of work or name

English

0 references

publication date

1 August 2005

1 reference

Journal of Clinical Investigation

29 July 2017

1 reference

29 July 2017

115

1 reference

29 July 2017

2059-2064

1 reference

29 July 2017

8

1 reference

Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis

29 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180557

PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180557

Role for Akt3/protein kinase Bgamma in attainment of normal brain size

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180557

Akt mediates the cross-talk between beta-adrenergic and insulin receptors in neonatal cardiomyocytes.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180557

The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180557

Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180557

A portrait of AKT kinases: human cancer and animal models depict a family with strong individualities

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180557

Phosphoinositide 3-kinase(p110α) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180557

IRS proteins and the common path to diabetes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180557

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180557

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180557

Reperfusion-activated Akt kinase prevents apoptosis in transgenic mouse hearts overexpressing insulin-like growth factor-1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180557

The conserved phosphoinositide 3-kinase pathway determines heart size in mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180557

Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180557

Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180557

Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180557

Mechanism of enhanced cardiac function in mice with hypertrophy induced by overexpressed Akt.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180557

Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180557

Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180557

Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180557

Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180557

Akt/protein kinase B promotes organ growth in transgenic mice

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180557

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180557

Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180557

Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16075047

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase(p110alpha) pathway

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16075047

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Minimally invasive aortic banding in mice: effects of altered cardiomyocyte insulin signaling during pressure overload

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16075047

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI25900

1 reference

29 July 2017

1 reference

29 July 2017

1 reference

PubMed ID

16075047