The brain alpha7 nicotinic receptor may be an important therapeutic target for the treatment of Alzheimer's disease: studies with DMXBA (GTS-21). (Q33913709)

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English	The brain alpha7 nicotinic receptor may be an important therapeutic target for the treatment of Alzheimer's disease: studies with DMXBA (GTS-21).	scientific article

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scholarly article

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Europe PubMed Central

30 July 2017

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Europe PubMed Central

The brain alpha7 nicotinic receptor may be an important therapeutic target for the treatment of Alzheimer's disease: studies with DMXBA (GTS-21). (English)

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Europe PubMed Central

30 July 2017

Alzheimer's disease

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author name string

Kem WR

1

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Europe PubMed Central

30 July 2017

language of work or name

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publication date

1 August 2000

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Europe PubMed Central

30 July 2017

Behavioural Brain Research

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Europe PubMed Central

30 July 2017

113

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Europe PubMed Central

30 July 2017

1-2

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Europe PubMed Central

30 July 2017

169-181

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Europe PubMed Central

30 July 2017

Nicotine-induced protection of cultured cortical neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxicity.

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Choline is a selective agonist of alpha7 nicotinic acetylcholine receptors in the rat brain neurons.

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7 January 2021

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Improved learning and memory in aged rats with chronic administration of the nicotinic receptor agonist GTS-21.

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Simultaneous determination of GTS-21 and its metabolite in rat plasma by high-performance liquid chromatography using solid-phase extraction.

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Metabolism and disposition of GTS-21, a novel drug for Alzheimer's disease

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alpha-Bungarotoxin binding sites in rat hippocampal and cortical cultures: initial characterisation, colocalisation with alpha 7 subunits and up-regulation by chronic nicotine treatment

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Human alpha 7 nicotinic acetylcholine receptor responses to novel ligands

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Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo

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Human alpha4beta2 neuronal nicotinic acetylcholine receptor in HEK 293 cells: A patch-clamp study

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Mammalian nicotinic receptors with alpha7 subunits that slowly desensitize and rapidly recover from alpha-bungarotoxin blockade.

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Postmortem stability of alpha-bungarotoxin binding sites in mouse and human brain.

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Diversity of neuronal nicotinic acetylcholine receptors: lessons from behavior and implications for CNS therapeutics

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In vitro neuroprotective properties of the novel cholinergic channel activator (ChCA), ABT-418.

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Nicotinic antagonist administration into the ventral hippocampus and spatial working memory in rats.

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Suppression of programmed neuronal death by sustained elevation of cytoplasmic calcium

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Synaptic potentials mediated via alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors in rat hippocampal interneurons.

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Nicotinic receptors in the rat prefrontal cortex: increase in glutamate release and facilitation of mediodorsal thalamo-cortical transmission.

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Hippocampal synaptic transmission enhanced by low concentrations of nicotine.

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Nicotinic agonists competitively antagonize serotonin at mouse 5-HT3 receptors expressed in Xenopus oocytes.

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A novel nicotinic agonist facilitates induction of long-term potentiation in the rat hippocampus.

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Alzheimer's drug design based upon an invertebrate toxin (anabaseine) which is a potent nicotinic receptor agonist.

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Nicotinic receptor stimulation protects neurons against beta-amyloid toxicity.

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Characterization of the neuroprotective and toxic effects of alpha7 nicotinic receptor activation in PC12 cells.

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Pharmacokinetics and urinary excretion of DMXBA (GTS-21), a compound enhancing cognition.

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Alpha4 but not alpha3 and alpha7 nicotinic acetylcholine receptor subunits are lost from the temporal cortex in Alzheimer's disease.

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3-[2,4-Dimethoxybenzylidene]anabaseine (DMXB) selectively activates rat alpha7 receptors and improves memory-related behaviors in a mecamylamine-sensitive manner

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Calcium influx through nicotinic receptor in rat central neurons: its relevance to cellular regulation

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Reduced number of [3H]nicotine and [3H]acetylcholine binding sites in the frontal cortex of Alzheimer brains.

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Mice deficient in the alpha7 neuronal nicotinic acetylcholine receptor lack alpha-bungarotoxin binding sites and hippocampal fast nicotinic currents

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An evaluation of neuronal nicotinic acetylcholine receptor activation by quaternary nitrogen compounds indicates that choline is selective for the alpha 7 subtype.

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A physiologically based pharmacokinetic model for nicotine disposition in the Sprague-Dawley rat.

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Nicotinic stimulation produces multiple forms of increased glutamatergic synaptic transmission.

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Evaluation of anti-nociceptive effects of neuronal nicotinic acetylcholine receptor (NAChR) ligands in the rat tail-flick assay

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Nicotinic alpha 7 receptors protect against glutamate neurotoxicity and neuronal ischemic damage.

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Selective alpha7-nicotinic agonists normalize inhibition of auditory response in DBA mice.

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Nicotinic acetylcholine receptor subtypes in human frontal cortex: changes in Alzheimer's disease.

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Pharmacological characterization of nicotinic receptor-mediated acetylcholine release in rat brain--an in vivo microdialysis study.

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GTS-21, a mixed nicotinic receptor agonist/antagonist, does not affect the nicotine cue

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Nicotinic acetylcholine binding sites in Alzheimer's disease.

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A nicotinic agonist (GTS-21), eyeblink classical conditioning, and nicotinic receptor binding in rabbit brain.

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Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists

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Nicotinic cholinergic system involvement in eyeblink classical conditioning in rabbits.

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Identifiers

10.1016/S0166-4328(00)00211-4

1 reference

Europe PubMed Central

30 July 2017

1 reference

Europe PubMed Central

30 July 2017

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