A review of the issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides (Q33916114)

30 July 2017

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title

A review of the issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides (English)

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30 July 2017

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A A Levin

1

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30 July 2017

language of work or name

English

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publication date

1 December 1999

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Biochimica et Biophysica Acta

30 July 2017

published in

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30 July 2017

volume

1489

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30 July 2017

issue

1

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30 July 2017

page(s)

69-84

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A pharmacokinetic evaluation of 14C-labeled afovirsen sodium in patients with genital warts.

30 July 2017

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Comparison of the toxicity profiles of ISIS 1082 and ISIS 2105, phosphorothioate oligonucleotides, following subacute intradermal administration in Sprague-Dawley rats

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Absorption, tissue distribution and in vivo stability in rats of a hybrid antisense oligonucleotide following oral administration

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Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice

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Review of in vivo pharmacokinetics and toxicology of phosphorothioate oligonucleotides.

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Development of a novel scintillation proximity competitive hybridization assay for the determination of phosphorothioate antisense oligonucleotide plasma concentrations in a toxicokinetic study

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Renal uptake of an 18-mer phosphorothioate oligonucleotide

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Pharmacokinetics, biodistribution, and stability of capped oligodeoxynucleotide phosphorothioates in mice

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7 January 2021

On-line HPLC electrospray mass spectrometry of phosphorothioate oligonucleotide metabolites

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7 January 2021

Characterization of oligonucleotide metabolism in vivo via liquid chromatography/electrospray tandem mass spectrometry with a quadrupole ion trap mass spectrometer

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Sequence specific inhibition of human type II phospholipase A2 enzyme activity by phosphorothioate oligonucleotides

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The antiproliferative activity of c-myb and c-myc antisense oligonucleotides in smooth muscle cells is caused by a nonantisense mechanism

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7 January 2021

Sequence context of antisense RelA/NF-kappa B phosphorothioates determines specificity

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7 January 2021

Phosphorothioate antisense oligodeoxynucleotides: questions of specificity

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Phosphorothioate oligodeoxynucleotides: antisense or anti-protein?

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Combinatorially selected guanosine-quartet structure is a potent inhibitor of human immunodeficiency virus envelope-mediated cell fusion

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7 January 2021

CpG motifs in bacterial DNA trigger direct B-cell activation

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7 January 2021

Bacterial DNA-Induced NK Cell IFN-γ Production Is Dependent on Macrophage Secretion of IL-12

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7 January 2021

Evaluation of the toxicity of ISIS 2302, a phosphorothioate oligonucleotide, in a 4-week study in CD-1 mice

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7 January 2021

CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma

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7 January 2021

Effect of antisense oligonucleotides on cytokine release from human keratinocytes in an in vitro model of skin

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DNA binding to human leukocytes. Evidence for a receptor-mediated association, internalization, and degradation of DNA

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7 January 2021

The role of CpG dinucleotides in DNA vaccines

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7 January 2021

Synthetic oligonucleotides: the development of antisense therapeutics

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7 January 2021

CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus

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7 January 2021

Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization

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7 January 2021

Pharmacology of antisense therapeutic agents : cancer and inflamination

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7 January 2021

Inhibition of interleukin-1 type I receptor expression in human cell-lines by an antisense phosphorothioate oligodeoxynucleotide

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7 January 2021

Inhibition of rabbit beta-globin synthesis by complementary oligonucleotides: identification of mRNA sites sensitive to inhibition

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7 January 2021

Implication of RNA structure on antisense oligonucleotide hybridization kinetics

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Potent and selective inhibition of gene expression by an antisense heptanucleotide

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7 January 2021

Characterization of Binding Sites, Extent of Binding, and Drug Interactions of Oligonucleotides with Albumin

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7 January 2021

Evaluation of the toxicity of ISIS 2302, a phosphorothioate oligonucleotide, in a four-week study in cynomolgus monkeys

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7 January 2021

A sense phosphorothioate oligonucleotide directed to the initiation codon of transcription factor NF-kappa B p65 causes sequence-specific immune stimulation.

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7 January 2021

Activation of the alternative pathway of complement: efficient fluid-phase amplification by blockade of the regulatory complement protein beta1H through sulfated polyanions

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7 January 2021

Inhibition of coagulation by a phosphorothioate oligonucleotide.

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7 January 2021

Animal models of antisense oligonucleotides: lessons for use in humans

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7 January 2021

Stereochemistry of the transesterification step of ribonuclease T 1 .

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Phosphate analogs for study of DNA polymerases

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Antisense inhibition of engrailed genes in mouse embryos reveals roles for these genes in craniofacial and neural tube development.

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7 January 2021

Antisense targeting of engrailed-1 causes abnormal axis formation in mouse embryos

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7 January 2021

Developmental abnormalities in cultured mouse embryos deprived of retinoic by inhibition of yolk-sac retinol binding protein synthesis

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7 January 2021

Effect on embryos of injection of phosphorothioate-modified oligonucleotides into pregnant mice.

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7 January 2021

10.1016/S0167-4781(99)00140-2

Identifiers

DOI

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30 July 2017

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