Diosgenin, a steroidal saponin, inhibits migration and invasion of human prostate cancer PC-3 cells by reducing matrix metalloproteinases expression (Q33918409)

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English	Diosgenin, a steroidal saponin, inhibits migration and invasion of human prostate cancer PC-3 cells by reducing matrix metalloproteinases expression	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Diosgenin, a steroidal saponin, inhibits migration and invasion of human prostate cancer PC-3 cells by reducing matrix metalloproteinases expression (English)

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

prostate cancer

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based on heuristic

inferred from title

author name string

Pin-Shern Chen

1

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Yuan-Wei Shih

2

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Europe PubMed Central

PubMed publication ID

30 July 2017

Hsiang-Ching Huang

3

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Hsing-Wen Cheng

4

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Europe PubMed Central

PubMed publication ID

30 July 2017

language of work or name

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publication date

23 May 2011

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Europe PubMed Central

PubMed publication ID

30 July 2017

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

e20164

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

copyright license

Creative Commons Attribution 4.0 International

23 May 2011

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April 2022 Public Data File from Crossref

copyright status

0 references

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Matrix metalloproteinases and tissue inhibitor of metalloproteinases are essential for the inflammatory response in cancer cells

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5 July 2018

Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells.

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Cancer statistics, 2009

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Cancer chemopreventive and therapeutic effects of diosgenin, a food saponin

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Activation of PI3K-Akt signaling pathway promotes prostate cancer cell invasion

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Inhibition of angiogenesis and invasion by 3,3'-diindolylmethane is mediated by the nuclear factor-kappaB downstream target genes MMP-9 and uPA that regulated bioavailability of vascular endothelial growth factor in prostate cancer

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Epigenetic inactivation of the tissue inhibitor of metalloproteinase-2 (TIMP-2) gene in human prostate tumors

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Cancer metastasis: building a framework

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5 July 2018

Inhibition of CD147 expression reduces tumor cell invasion in human prostate cancer cell line via RNA interference

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Oncogenic PI3K and its role in cancer

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Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, I kappa B kinase activation and NF-kappa B-regulated gene expression

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Silibinin inhibits cell invasion through inactivation of both PI3K-Akt and MAPK signaling pathways

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Prostate cancer: the role of hormonal therapy

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5 July 2018

Hypoglycemic effects of steroidal sapogenins isolated from Jamaican bitter yam, Dioscorea polygonoides

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The role of gelatinases in colorectal cancer progression and metastasis

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5 July 2018

Diosgenin dose-dependent apoptosis and differentiation induction in human erythroleukemia cell line and sedimentation field-flow fractionation monitoring.

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5 July 2018

Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca2+ homeostasis

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5 July 2018

Diosgenin, a steroid saponin of Trigonella foenum graecum (Fenugreek), inhibits azoxymethane-induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT-29 human colon cancer cells.

1 reference

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5 July 2018

Nuclear factor-inducing kinase plays a crucial role in osteopontin-induced MAPK/IkappaBalpha kinase-dependent nuclear factor kappaB-mediated promatrix metalloproteinase-9 activation

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Induction of antiproliferative effect by diosgenin through activation of p53, release of apoptosis-inducing factor (AIF) and modulation of caspase-3 activity in different human cancer cells.

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Role of matrix metalloproteinases (MMPs) in colorectal cancer

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Regulation of matrix metalloproteinases: an overview

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Different contribution of apoptosis to the antiproliferative effects of diosgenin and other plant steroids, hecogenin and tigogenin, on human 1547 osteosarcoma cells.

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The biological action of saponins in animal systems: a review

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Matrix metalloproteinases in cancer.

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Mechanisms involved in the progression of androgen-independent prostate cancers: it is not only the cancer cell's fault

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A plant steroid, diosgenin, induces apoptosis, cell cycle arrest and COX activity in osteosarcoma cells

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Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production

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Increased gelatinase A (MMP-2) and cathepsin B activity in invasive tumor regions of human colon cancer samples.

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Changes in lipoxygenase activities in human erythroleukemia (HEL) cells during diosgenin-induced differentiation

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Establishment and characterization of a human prostatic carcinoma cell line (PC-3)

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Diosgenin targets Akt-mediated prosurvival signaling in human breast cancer cells

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Matrix metalloproteinase activity, bone matrix turnover, and tumor cell proliferation in prostate cancer bone metastasis

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Mechanisms of tumour metastasis

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12 December 2020

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Matrilysin expression in the involuting rat ventral prostate

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In vivo and in vitro studies of hypocholesterolemic effects of diosgenin in rats

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Matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) from HT 1080 human fibrosarcoma cells. Purification and activation of the precursor and enzymic properties

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https://pubmed.ncbi.nlm.nih.gov/21629786

12 December 2020

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Cell migration through three-dimensional gels of native collagen fibres: collagenolytic activity is not required for the migration of two permanent cell lines

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12 December 2020

based on heuristic

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Evidence for increased activated metalloproteinase 2 (MMP-2a) expression associated with human prostate cancer progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/21629786

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diosgenin, a Steroid Saponin of Trigonella foenum graecum (Fenugreek), Inhibits Azoxymethane-Induced Aberrant Crypt Foci Formation in F344 Rats and Induces Apoptosis in HT-29 Human Colon Cancer Cells

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.1158/1055-9965.1392.13.8

Identifiers

10.1371/JOURNAL.PONE.0020164

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

2011PLoSO...620164C

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

ResearchGate publication ID

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