Will targeting insulin growth factor help us or hurt us?: An oncologist's perspective (Q33926307)

30 July 2017

1 reference

title

Will targeting insulin growth factor help us or hurt us?: An oncologist's perspective (English)

1 reference

30 July 2017

1 reference

Mitchell Kamrava

1

1 reference

30 July 2017

David Gius

series ordinal

2

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30 July 2017

Giovanna Casagrande

series ordinal

3

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30 July 2017

Elise Kohn

series ordinal

4

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30 July 2017

publication date

5 November 2009

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30 July 2017

published in

Ageing Research Reviews

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30 July 2017

volume

10

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30 July 2017

issue

1

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30 July 2017

page(s)

62-70

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Reversibility and recurrence of IGF-IR-induced mammary tumors

30 July 2017

cites work

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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A prospective evaluation of insulin and insulin-like growth factor-I as risk factors for endometrial cancer

5 July 2018

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5 July 2018

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Functionally significant insulin-like growth factor I receptor mutations in centenarians

5 July 2018

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Structural basis for the lower affinity of the insulin-like growth factors for the insulin receptor

5 July 2018

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Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

5 July 2018

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Transgenic overexpression of pregnancy-associated plasma protein-A increases the somatic growth and skeletal muscle mass in mice.

5 July 2018

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Brain IRS2 signaling coordinates life span and nutrient homeostasis

5 July 2018

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Alternate-day fasting and chronic disease prevention: a review of human and animal trials

5 July 2018

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Phase I pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1.

5 July 2018

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Role of the integrin alphaVbeta3 in mediating increased smooth muscle cell responsiveness to IGF-I in response to hyperglycemic stress

5 July 2018

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The role of insulin receptor isoforms and hybrid insulin/IGF-I receptors in human cancer.

5 July 2018

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Aging, adiposity, and calorie restriction

5 July 2018

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Pregnancy-associated plasma protein-A (PAPP-A): a local regulator of IGF bioavailability through cleavage of IGFBPs

5 July 2018

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Tumor metastasis: mechanistic insights and clinical challenges

5 July 2018

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Alpha-V-dependent outside-in signaling is required for the regulation of CD44 surface expression, MMP-2 secretion, and cell migration by osteopontin in human melanoma cells

5 July 2018

1 reference

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Control of aging and longevity by IGF-I signaling

5 July 2018

1 reference

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Suppression of aging in mice by the hormone Klotho

5 July 2018

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The plasticity of aging: insights from long-lived mutants

5 July 2018

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Hormone-treated snell dwarf mice regain fertility but remain long lived and disease resistant

5 July 2018

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5 July 2018

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Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body

5 July 2018

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Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis

5 July 2018

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Genetic mouse models of extended lifespan

5 July 2018

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Cadherin-mediated cell-cell adhesion: sticking together as a family

5 July 2018

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Cell migration: integrating signals from front to back

5 July 2018

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The IGF‐1 receptor in cancer biology

5 July 2018

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Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3'-kinase/AKT signaling.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888889

Serum levels of insulin-like growth factor I and its binding proteins in health and disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888889

The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888889

Role of integrins in cell invasion and migration

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888889

Extended longevity in mice lacking the insulin receptor in adipose tissue

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888889

Role of the IGF-I receptor in the regulation of cell-cell adhesion: implications in cancer development and progression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888889

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888889

Growth hormone insensitivity (Laron syndrome).

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888889

Low serum insulin-like growth factor I is associated with increased risk of ischemic heart disease: a population-based case-control study

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888889

Insulin-like growth factor binding protein-1 (IGFBP-1) inhibits breast cancer cell motility.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888889

The cadherin-catenin adhesion system in signaling and cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888889

Insulin-like growth factor-binding protein 1 stimulates human trophoblast migration by signaling through alpha 5 beta 1 integrin via mitogen-activated protein Kinase pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888889

Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888889

A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888889

Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888889

Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin

5 July 2018

1 reference

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Structure and function of the type 1 insulin-like growth factor receptor.

5 July 2018

1 reference

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5 July 2018

The Hallmarks of Cancer

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Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3.

5 July 2018

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Anti-apoptotic signaling of the IGF-I receptor in fibroblasts following loss of matrix adhesion

5 July 2018

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Blocking ligand occupancy of the alphaVbeta3 integrin inhibits insulin-like growth factor I signaling in vascular smooth muscle cells

5 July 2018

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Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

5 July 2018

1 reference

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daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans

5 July 2018

1 reference

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daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans

5 July 2018

1 reference

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Reduced cell attachment and phosphorylation of focal adhesion kinase associated with expression of a mutant insulin receptor

5 July 2018

1 reference

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Dwarf mice and the ageing process.

5 July 2018

1 reference

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Tyrosine phosphorylation and enhanced expression of paxillin during neuronal differentiation in vitro

5 July 2018

1 reference

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Cell migration: a physically integrated molecular process

5 July 2018

1 reference

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A C. elegans mutant that lives twice as long as wild type

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888889

Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888889

Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer.

5 July 2018

1 reference

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Aging and cancer: killing two birds with one worm.

29 October 2018

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DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans

29 October 2018

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Prediagnostic plasma C-peptide and pancreatic cancer risk in men and women.

29 October 2018

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The prospective association of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-1 levels with all cause and cardiovascular disease mortality in older adults: the Rancho Bernardo Study

29 October 2018

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Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 as predictors of advanced-stage prostate cancer.

29 October 2018

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Prevention of cytokine-induced apoptosis by insulin-like growth factor-I is independent of cell adhesion molecules in HT29-D4 colon carcinoma cells-evidence for a NF-kappaB-dependent survival mechanism

29 October 2018

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Relevance of biologic markers in colorectal carcinoma: a comparative study of a broad panel

29 October 2018

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Insulin-like growth factor-1 receptor in uveal melanoma: a predictor for metastatic disease and a potential therapeutic target

29 October 2018

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A polymorphism in the gene for IGF-I: functional properties and risk for type 2 diabetes and myocardial infarction

29 October 2018

1 reference

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Assessment of growth parameters and life span of GHR/BP gene-disrupted mice.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888889

The activated insulin-like growth factor I receptor induces depolarization in breast epithelial cells characterized by actin filament disassembly and tyrosine dephosphorylation of FAK, Cas, and paxillin.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888889

Insulin-like growth factors (IGF) enhance three-dimensional (3D) growth of human glioblastomas.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2888889

Reduced expression of insulin-like growth factor I receptors in MCF-7 breast cancer cells leads to a more metastatic phenotype

29 October 2018

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12 December 2020

Expression of insulin-like growth factor-1 receptor in synovial sarcoma: association with an aggressive phenotype

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12 December 2020

Insulin-like growth factors and neoplasia

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12 December 2020

Patients with congenital deficiency of IGF-I seem protected from the development of malignancies: A preliminary report

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12 December 2020

Insulin-like growth factors, insulin, and epidermal growth factor cause rapid cytoskeletal reorganization in KB cells. Clarification of the roles of type I insulin-like growth factor receptors and insulin receptors

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12 December 2020

Somatostatin analogue octreotide enhances the antineoplastic effects of tamoxifen and ovariectomy on 7,12-dimethylbenz(alpha)anthracene-induced rat mammary carcinomas

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12 December 2020

Insulin-like growth factor (IGF)-binding proteins inhibit the smooth muscle cell migration responses to IGF-I and IGF-II

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12 December 2020

Overexpressed IGF-I receptors reduce estrogen growth requirements, enhance survival, and promote E-cadherin-mediated cell-cell adhesion in human breast cancer cells

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12 December 2020

Loss of pregnancy-associated plasma protein A extends lifespan in mice

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12 December 2020

Picropodophyllin induces downregulation of the insulin-like growth factor 1 receptor: potential mechanistic involvement of Mdm2 and beta-arrestin1

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12 December 2020

Hyper-insulinaemia and cancer, meta-analyses of epidemiological studies

1 reference

12 December 2020

Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity

1 reference

12 December 2020

10.1016/J.ARR.2009.10.007

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DOI

1 reference

30 July 2017

1 reference

30 July 2017

1 reference