Rac1 mediates STAT3 activation by autocrine IL-6 (Q33929488)

30 July 2017

title

Rac1 mediates STAT3 activation by autocrine IL-6 (English)

1 reference

30 July 2017

T R Faruqi

1

1 reference

30 July 2017

D Gomez

2

1 reference

30 July 2017

X R Bustelo

3

1 reference

30 July 2017

D Bar-Sagi

4

1 reference

30 July 2017

N C Reich

5

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30 July 2017

language of work or name

English

0 references

publication date

24 July 2001

1 reference

Proceedings of the National Academy of Sciences of the United States of America

30 July 2017

published in

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30 July 2017

volume

98

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30 July 2017

issue

16

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30 July 2017

page(s)

9014-9019

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Specificity of signaling by STAT1 depends on SH2 and C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression

30 July 2017

cites work

1 reference

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5 July 2018

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Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo

5 July 2018

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Interleukin-6-induced STAT3 transactivation and Ser727 phosphorylation involves Vav, Rac-1 and the kinase SEK-1/MKK-4 as signal transduction components

5 July 2018

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5 July 2018

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Requirement for Ras/Rac1-mediated p38 and c-Jun N-terminal kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein

5 July 2018

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Integration of Rac-dependent regulation of cyclin D1 transcription through a nuclear factor-kappaB-dependent pathway

5 July 2018

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5 July 2018

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Tyrosine phosphorylation of Vav stimulates IL-6 production in mast cells by a Rac/c-Jun N-terminal kinase-dependent pathway

5 July 2018

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A single amino acid substitution in the v-Eyk intracellular domain results in activation of Stat3 and enhances cellular transformation.

5 July 2018

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Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2

5 July 2018

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How cells respond to interferons

5 July 2018

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Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

5 July 2018

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Activation of STAT transcription factors in oncogenic tyrosine kinase signaling

5 July 2018

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5 July 2018

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STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation

5 July 2018

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5 July 2018

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STATs and gene regulation

5 July 2018

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The small GTPases Cdc42Hs, Rac1 and RhoG delineate Raf-independent pathways that cooperate to transform NIH3T3 cells

5 July 2018

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A family of cytokine-inducible inhibitors of signalling

5 July 2018

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Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation

5 July 2018

1 reference

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Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3.

5 July 2018

1 reference

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rac1 regulates a cytokine-stimulated, redox-dependent pathway necessary for NF-kappaB activation

5 July 2018

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RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase

5 July 2018

1 reference

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STAT3beta, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription

5 July 2018

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Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS.

5 July 2018

1 reference

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Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction

5 July 2018

1 reference

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Proteins regulating Ras and its relatives

5 July 2018

1 reference

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Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6

5 July 2018

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Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway.

5 July 2018

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Activation of Raf as a result of recruitment to the plasma membrane

5 July 2018

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Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation

5 July 2018

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Requirement of serine phosphorylation for formation of STAT-promoter complexes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=55365

An essential role for Rac in Ras transformation

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=55365

Characterization of the interleukin-4 nuclear activated factor/STAT and its activation independent of the insulin receptor substrate proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=55365

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=55365

Transcriptional responses to polypeptide ligands: the JAK-STAT pathway

5 July 2018

1 reference

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Cytokine receptor signalling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=55365

Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=55365

Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=55365

Mechanism of activation of an N-ras gene in the human fibrosarcoma cell line HT1080

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=55365

ras oncogenes in human cancer: a review

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=55365

vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=55365

Activation of interleukin-6 gene expression through the NF-kappa B transcription factor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=55365

DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=55365

The Rac1/p38 mitogen-activated protein kinase pathway is required for interferon alpha-dependent transcriptional activation but not serine phosphorylation of Stat proteins

5 July 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11470914

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

IkappaB-NF-kappaB structures: at the interface of inflammation control

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11470914

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

c-Src activates the DNA binding and transcriptional activity of Stat3 molecules: serine 727 is not required for transcriptional activation under certain circumstances

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11470914

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.161281298

1 reference

30 July 2017

0 references

1 reference

30 July 2017

1 reference