Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels (Q33930004)

30 July 2017

title

Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels (English)

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A Bonnefond

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Philippe Froguel

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P Froguel

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author name string

D A Baerenwald

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B P Flemming

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O C Umunakwe

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J K Oeser

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L D Pound

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N L Conley

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S Cauchi

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S Lobbens

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E Eury

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B Balkau

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O Lantieri

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MAGIC Investigators

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P K Dadi

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D A Jacobson

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R M O'Brien

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publication date

19 March 2013

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volume

56

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issue

6

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page(s)

1306-1316

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A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets

30 July 2017

cites work

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Genetic and functional assessment of the role of the rs13431652-A and rs573225-A alleles in the G6PC2 promoter that are strongly associated with elevated fasting glucose levels.

28 July 2018

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Foxa1 and Foxa2 maintain the metabolic and secretory features of the mature beta-cell

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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

28 July 2018

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Glucose-6-phosphatase catalytic subunit gene family

28 July 2018

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Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk

28 July 2018

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A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

28 July 2018

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Variants in MTNR1B influence fasting glucose levels

28 July 2018

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A single-nucleotide polymorphism in a methylatable Foxa2 binding site of the G6PC2 promoter is associated with insulin secretion in vivo and increased promoter activity in vitro

28 July 2018

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Foxa2 and MafA regulate islet-specific glucose-6-phosphatase catalytic subunit-related protein gene expression

28 July 2018

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Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations

28 July 2018

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Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels

28 July 2018

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The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes

28 July 2018

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Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

28 July 2018

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Alternative splicing of G6PC2, the gene coding for the islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), results in differential expression in human thymus and spleen compared with pancreas

28 July 2018

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A pancreatic beta-cell-specific homolog of glucose-6-phosphatase emerges as a major target of cell-mediated autoimmunity in diabetes

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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21 January 2018

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A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels

21 January 2018

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Use of HbA1c in predicting progression to diabetes in French men and women: data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR).

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Plasma glucose concentration and prediction of future risk of type 2 diabetes

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A genetic variant of G6PC2 is associated with type 2 diabetes and fasting plasma glucose level in the Chinese population

21 January 2018

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The proximal islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen promoter is sufficient to initiate but not maintain transgene expression in mouse islets in vivo

21 January 2018

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21 January 2018

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10.1007/S00125-013-2875-3

21 January 2018

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30 July 2017

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30 July 2017

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