NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and modulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenografts (Q33932080)

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English	NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and modulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenografts	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

30 July 2017

NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and modulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenografts (English)

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

1 reference

based on heuristic

inferred from title

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based on heuristic

inferred from title

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based on heuristic

inferred from title

4

object named as

Louis J Ignarro

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Europe PubMed Central

PubMed publication ID

30 July 2017

author name string

Karuppaiyah Selvendiran

1

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Europe PubMed Central

PubMed publication ID

30 July 2017

Anna Bratasz

2

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Europe PubMed Central

PubMed publication ID

30 July 2017

Liyue Tong

3

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Europe PubMed Central

PubMed publication ID

30 July 2017

Periannan Kuppusamy

5

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Europe PubMed Central

PubMed publication ID

30 July 2017

publication date

28 September 2007

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Europe PubMed Central

PubMed publication ID

30 July 2017

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Europe PubMed Central

PubMed publication ID

30 July 2017

7

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Europe PubMed Central

PubMed publication ID

30 July 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

81-88

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Dual inhibition of PI3K/Akt signaling and the DNA damage checkpoint in p53-deficient cells with strong survival signaling: implications for cancer therapy

1 reference

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Mismatch repair status and the response of human cells to cisplatin

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NO-releasing aspirin exerts stronger growth inhibitory effect on Barrett's adenocarcinoma cells than traditional aspirin

1 reference

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Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK

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The role of constitutively active signal transducer and activator of transcription 3 in ovarian tumorigenesis and prognosis

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Signal transducers and activators of transcription 3 pathway activation in drug-resistant ovarian cancer

1 reference

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1 reference

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Receptor tyrosine kinase (RTK) inhibition is effective in chemosensitising EGFR-expressing drug resistant human ovarian cancer cell lines when used in combination with cytotoxic agents

1 reference

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Nitrogen oxide-releasing aspirin induces histone H2AX phosphorylation, ATM activation and apoptosis preferentially in S-phase cells: involvement of reactive oxygen species

1 reference

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Role of PI3K and AKT specific isoforms in ovarian cancer cell migration, invasion and proliferation through the p70S6K1 pathway

1 reference

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Nitric oxide-releasing aspirin and indomethacin are potent inhibitors against colon cancer in azoxymethane-treated rats: effects on molecular targets

1 reference

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Novel therapeutic agents in ovarian cancer

1 reference

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Luteolin promotes degradation in signal transducer and activator of transcription 3 in human hepatoma cells: an implication for the antitumor potential of flavonoids

1 reference

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Nitric oxide and cisplatin resistance: NO easy answers

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Cancer statistics, 2006

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5 July 2018

Reversal to cisplatin sensitivity in recurrent human ovarian cancer cells by NCX-4016, a nitro derivative of aspirin

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Gefitinib, a selective EGFR tyrosine kinase inhibitor, induces apoptosis through activation of Bax in human gallbladder adenocarcinoma cells

1 reference

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Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway

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Inhibition of the epidermal growth factor receptor increases expression of genes that stimulate inflammation, apoptosis, and cell attachment

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The STATs of cancer--new molecular targets come of age

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Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2890223

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Targeting HER1/EGFR: a molecular approach to cancer therapy

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Activation of epidermal growth factor receptor signals induction of nitric oxide synthase-2 in human optic nerve head astrocytes in glaucomatous optic neuropathy

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NCX 4016, a nitric oxide-releasing aspirin derivative, exhibits a significant antiproliferative effect and alters cell cycle progression in human colon adenocarcinoma cell lines

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A decade of tyrosine kinases: from gene discovery to therapeutics

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Cytoplasmic transport of Stat3 by receptor-mediated endocytosis

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Cytochemical methods for the detection of apoptosis

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Regulation of cell death protease caspase-9 by phosphorylation

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Apoptosis in cancer therapy: crossing the threshold

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Akt-mediated cisplatin resistance in ovarian cancer: modulation of p53 action on caspase-dependent mitochondrial death pathway

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12 December 2020

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10.4161/CC.7.1.5103

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Europe PubMed Central

PubMed publication ID

30 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

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