Site-specific modifications and toxicity of blood substitutes. The case of diaspirin cross-linked hemoglobin (Q33933535)

30 July 2017

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title

Site-specific modifications and toxicity of blood substitutes. The case of diaspirin cross-linked hemoglobin (English)

1 reference

30 July 2017

D'Agnillo F

1

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PubMed ID

10837790

30 July 2017

Alayash AI

series ordinal

2

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PubMed ID

10837790

30 July 2017

language of work or name

English

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publication date

1 February 2000

1 reference

Advanced Drug Delivery Reviews

30 July 2017

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30 July 2017

40

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30 July 2017

3

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30 July 2017

199-212

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Future prospects for artificial blood

30 July 2017

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Hemoglobin and free radicals: implications for the development of a safe blood substitute

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Diaspirins that crosslink .beta. chains of hemoglobin: bis(3,5-dibromosalicyl) succinate and bis(3,5-dibromosalicyl) fumarate

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Structural characterization of human hemoglobin crosslinked by bis(3,5-dibromosalicyl) fumarate using mass spectrometric techniques

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Pharmacologic profile of diaspirin cross-linked hemoglobin in hemodialysis patients.

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Evaluation of a stroma-free hemoglobin solution for use as a plasma expander

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A clinical safety trial of stroma-free hemoglobin

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Virus inactivation in hemoglobin solutions by heat

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7 January 2021

Effects of polymerization on the oxygen carrying and redox properties of diaspirin cross-linked hemoglobin

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Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage

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Oxygen delivery and autoxidation of hemoglobin

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7 January 2021

The effect of crosslinking by bis(3,5-dibromosalicyl) fumarate on the autoxidation of hemoglobin

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7 January 2021

Reaction of human hemoglobin HbA0 and two cross-linked derivatives with hydrogen peroxide: differential behavior of the ferryl intermediate

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Detection and characterization of lipid hydroperoxides at picomole levels by high-performance liquid chromatography

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Neutrophils kill pulmonary endothelial cells by a hydrogen-peroxide-dependent pathway. An in vitro model of neutrophil-mediated lung injury

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Reactive oxygen intermediates in biochemistry

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The globin-based free radical of ferryl hemoglobin is detected in normal human blood

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7 January 2021

Differential susceptibilities of the prosthetic heme of hemoglobin-based red cell substitutes. Implications in the design of safer agents.

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Iron promoters of the Fenton reaction and lipid peroxidation can be released from haemoglobin by peroxides

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7 January 2021

Reactions of cross-linked ferric haemoglobins with hydrogen peroxide

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7 January 2021

Arterial blood pressure responses to cell-free hemoglobin solutions and the reaction with nitric oxide

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Nitric oxide binding to human ferrihemoglobins cross-linked between either alpha or beta subunits

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7 January 2021

Rate of reaction with nitric oxide determines the hypertensive effect of cell-free hemoglobin.

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7 January 2021

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

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7 January 2021

Peroxynitrite-mediated heme oxidation and protein modification of native and chemically modified hemoglobins

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7 January 2021

Peroxynitrite Induces Long-Lived Tyrosyl Radical(s) in Oxyhemoglobin of Red Blood Cells through a Reaction Involving CO2and a Ferryl Species†

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7 January 2021

Reaction of Human Endothelial Cells to Bovine Hemoglobin Solutions and Tumor Necrosis Factor

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Pro-oxidant effects of cross-linked haemoglobins explored using liposome and cytochrome c oxidase vesicle model membranes

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Hemoglobin: a lifesaver and an oxidant. How to tip the balance.

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Toxic effect of hemoglobin on spinal cord neurons in culture

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Heme protein-mediated renal injury: A protective role for 21-aminosteroids in vitro and in vivo

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Hemoglobin A0 and alpha-crosslinked hemoglobin (alpha-DBBF) potentiate agonist-induced platelet aggregation through the platelet thromboxane receptor

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7 January 2021

Effects of bacterial endotoxin on human cross-linked and native hemoglobins.

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Methemoglobin formation after administration of hemoglobin conjugated to carboxylate dextran in guinea pigs. Attempts to prevent the oxidation of hemoglobin.

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7 January 2021

Limitations of the efficacy of hemoglobin-based oxygen-carrying solutions.

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7 January 2021

Hemoglobin based oxygen carriers: how much methemoglobin is too much?

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Physiologic mechanisms of postischemic tissue injury

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A causative role for redox cycling of myoglobin and its inhibition by alkalinization in the pathogenesis and treatment of rhabdomyolysis-induced renal failure.

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7 January 2021

Liver and kidney injury after administration of hemoglobin cross-linked with bis(3,5-dibromosalicyl) fumarate

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Hepatic inflammatory responses to alphaalpha-cross-linked hemoglobin infusion in rats.

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7 January 2021

Pharmacology of hemoglobin therapeutics

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7 January 2021

Systemic and pulmonary hypertension after resuscitation with cell-free hemoglobin

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7 January 2021

Mechanism of the acute pressor effect and bradycardia elicited by diaspirin crosslinked hemoglobin in anesthetized rats

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7 January 2021

Effects of polymerization on the hypertensive action of diaspirin cross-linked hemoglobin in rats

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Recombinant human hemoglobin does not affect renal function in humans: analysis of safety and pharmacokinetics

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Initial evaluation of diaspirin cross-linked hemoglobin (DCLHb) as a vasopressor in critically ill patients

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7 January 2021

Cardiovascular toxicity of human cross-linked hemoglobin in a rabbit endotoxemia model

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7 January 2021

Effect of diaspirin cross-linked hemoglobin on endothelin-1 and blood pressure in acute ischemic stroke in man.

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7 January 2021

Diaspirin crosslinked hemoglobin (DCLHb): control of pressor effect with anti-hypertensive agents

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7 January 2021

Alpha-alpha diaspirin crosslinked hemoglobin, nitric oxide, and cerebral ischemic injury in rats

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7 January 2021

Polyhemoglobin-superoxide dismutase-catalase as a blood substitute with antioxidant properties

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7 January 2021

Genetic Engineering of Myoglobin as a Simple Prototype for Hemoglobin-Based Blood Substitutes

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7 January 2021

Protein engineering strategies for designing more stable hemoglobin-based blood substitutes

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7 January 2021

Reactions of sperm whale myoglobin with hydrogen peroxide. Effects of distal pocket mutations on the formation and stability of the ferryl intermediate.

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7 January 2021

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Identifiers

DOI

1 reference

30 July 2017

1 reference

PubMed ID

10837790