Small heat-shock proteins interact with a flanking domain to suppress polyglutamine aggregation. (Q33935094)

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2 February 2020

title

Small heat-shock proteins interact with a flanking domain to suppress polyglutamine aggregation (English)

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2 February 2020

2

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2 February 2020

Heath Ecroyd

4

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2 February 2020

Martin J. Scanlon

5

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2 February 2020

John Carver

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2 February 2020

7

Stephen P Bottomley

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2 February 2020

author name string

Amy L Robertson

1

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2 February 2020

Helen M Saunders

3

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2 February 2020

language of work or name

English

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publication date

19 May 2010

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Proceedings of the National Academy of Sciences of the United States of America

2 February 2020

published in

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2 February 2020

volume

107

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2 February 2020

issue

23

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2 February 2020

page(s)

10424-10429

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The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation

2 February 2020

cites work

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Single homopolypeptide chains collapse into mechanically rigid conformations

28 July 2018

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The structural impact of a polyglutamine tract is location-dependent

28 July 2018

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Crystallin proteins and amyloid fibrils

28 July 2018

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Monitoring the prevention of amyloid fibril formation by alpha-crystallin. Temperature dependence and the nature of the aggregating species

28 July 2018

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Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila

28 July 2018

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Fluorescence correlation spectroscopy shows that monomeric polyglutamine molecules form collapsed structures in aqueous solutions

28 July 2018

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Mimicking phosphorylation of alphaB-crystallin affects its chaperone activity

28 July 2018

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Flanking sequences profoundly alter polyglutamine toxicity in yeast

28 July 2018

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Extended polyglutamine tracts cause aggregation and structural perturbation of an adjacent beta barrel protein

28 July 2018

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Some like it hot: the structure and function of small heat-shock proteins.

28 July 2018

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AlphaB-crystallin, a small heat-shock protein, prevents the amyloid fibril growth of an amyloid beta-peptide and beta2-microglobulin

28 July 2018

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The solution structure of the Josephin domain of ataxin-3: structural determinants for molecular recognition

28 July 2018

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The AXH domain adopts alternative folds the solution structure of HBP1 AXH.

28 July 2018

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28 July 2018

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Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin

28 July 2018

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Thioredoxin fold as homodimerization module in the putative chaperone ERp29: NMR structures of the domains and experimental model of the 51 kDa dimer

28 July 2018

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Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

28 July 2018

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The interaction of the molecular chaperone, alpha-crystallin, with molten globule states of bovine alpha-lactalbumin

28 July 2018

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28 July 2018

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Effects of site-directed mutations on the chaperone-like activity of alphaB-crystallin.

21 January 2018

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Accumulation of alpha B-crystallin in central nervous system glia and neurons in pathologic conditions

28 July 2018

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alpha B-crystallin is present in reactive glia in Creutzfeldt-Jakob disease

28 July 2018

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alpha B crystallin expression in non-lenticular tissues and selective presence in ubiquitinated inclusion bodies in human disease.

28 July 2018

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Small heat shock proteins inhibit amyloid-beta protein aggregation and cerebrovascular amyloid-beta protein toxicity.

28 July 2018

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The molecular chaperone, alpha-crystallin, inhibits amyloid formation by apolipoprotein C-II.

21 January 2018

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The interaction of the molecular chaperone alpha-crystallin with unfolding alpha-lactalbumin: a structural and kinetic spectroscopic study

21 January 2018

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The selective inhibition of serpin aggregation by the molecular chaperone, alpha-crystallin, indicates a nucleation-dependent specificity

21 January 2018

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Huntington's disease age-of-onset linked to polyglutamine aggregation nucleation

21 January 2018

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The two-stage pathway of ataxin-3 fibrillogenesis involves a polyglutamine-independent step.

21 January 2018

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Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism

21 January 2018

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The interplay between PolyQ and protein context delays aggregation by forming a reservoir of protofibrils

21 January 2018

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HspB8 participates in protein quality control by a non-chaperone-like mechanism that requires eIF2{alpha} phosphorylation

21 January 2018

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HspB8, a small heat shock protein mutated in human neuromuscular disorders, has in vivo chaperone activity in cultured cells.

21 January 2018

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Interaction of the molecular chaperone alphaB-crystallin with alpha-synuclein: effects on amyloid fibril formation and chaperone activity

21 January 2018

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Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

21 January 2018

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Identification of protein surfaces by NMR measurements with a pramagnetic Gd(III) chelate

21 January 2018

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Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers.

21 January 2018

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Amino acid sequences flanking polyglutamine stretches influence their potential for aggregate formation

21 January 2018

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Comparative analysis of genetic modifiers in Drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseases

21 January 2018

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Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila.

21 January 2018

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Structure validation of the Josephin domain of ataxin-3: conclusive evidence for an open conformation.

21 January 2018

1 reference

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The N-terminal domain of alphaB-crystallin is protected from proteolysis by bound substrate.

21 January 2018

1 reference

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Substrate binding site flexibility of the small heat shock protein molecular chaperones

21 January 2018

1 reference

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Polyglutamine expansion in ataxin-3 does not affect protein stability: implications for misfolding and disease.

21 January 2018

1 reference

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Lens alpha-crystallin: chaperone-like properties

21 January 2018

1 reference

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Josephin domain of ataxin-3 contains two distinct ubiquitin-binding sites.

21 January 2018

1 reference

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Pathogenic and Non-pathogenic Polyglutamine Tracts Have Similar Structural Properties: Towards a Length-dependent Toxicity Gradient

29 October 2018

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Structural and functional analysis of the Josephin domain of the polyglutamine protein ataxin-3

21 January 2018

1 reference

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Mechanisms of Ataxin-3 Misfolding and Fibril Formation: Kinetic Analysis of a Disease-associated Polyglutamine Protein

21 January 2018

1 reference

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Temperature-induced exposure of hydrophobic surfaces and its effect on the chaperone activity of alpha-crystallin

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20484674

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Structural alterations of alpha-crystallin during its chaperone action

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20484674

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Characterization of the structure and the amyloidogenic properties of the Josephin domain of the polyglutamine-containing protein ataxin-3

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20484674

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0914773107

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2 February 2020

0 references

1 reference

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2 February 2020

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