T cell receptor binding kinetics required for T cell activation depend on the density of cognate ligand on the antigen-presenting cell. (Q33935247)

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9 January 2020

title

T cell receptor binding kinetics required for T cell activation depend on the density of cognate ligand on the antigen-presenting cell (English)

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9 January 2020

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Pablo Alberto Gonzalez

1

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9 January 2020

Daniel Coombs

3

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9 January 2020

Alexis M Kalergis

8

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9 January 2020

author name string

Leandro J Carreño

2

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9 January 2020

Jorge E Mora

4

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9 January 2020

Edith Palmieri

5

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Byron Goldstein

6

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9 January 2020

Stanley G Nathenson

7

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language of work or name

English

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publication date

16 March 2005

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Proceedings of the National Academy of Sciences of the United States of America

9 January 2020

published in

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volume

102

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issue

13

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9 January 2020

page(s)

4824-4829

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Salmonella escape from antigen presentation can be overcome by targeting bacteria to Fc gamma receptors on dendritic cells

9 January 2020

cites work

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Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation

28 July 2018

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Modulation of T cell immunity by TCR/pMHC dwell time and activating/inhibitory receptor pairs on the antigen-presenting cell

28 July 2018

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A temporal and spatial summation model for T-cell activation: signal integration and antigen decoding

28 July 2018

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Endo- and exocytic rate constants for spontaneous and protein kinase C-activated T cell receptor cycling

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Discrepancy between ELISPOT IFN-gamma secretion and binding of A2/peptide multimers to TCR reveals interclonal dissociation of CTL effector function from TCR-peptide/MHC complexes half-life

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Role of the T cell receptor ligand affinity in T cell activation by bacterial superantigens

28 July 2018

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Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2

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Viral immune evasion strategies and the underlying cell biology

28 July 2018

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On the dynamics of TCR:CD3 complex cell surface expression and downmodulation

28 July 2018

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The immunological synapse: a molecular machine controlling T cell activation

28 July 2018

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Structural basis of T cell recognition

28 July 2018

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A kinetic basis for T cell receptor repertoire selection during an immune response

28 July 2018

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Down-regulation of HLA class I antigen-processing molecules in malignant melanoma: association with disease progression

28 July 2018

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Peptide antagonism and T cell receptor interactions with peptide-MHC complexes

28 July 2018

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Role of CD8 in aberrant function of cytotoxic T lymphocytes

28 July 2018

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Serial triggering of TCRs: a basis for the sensitivity and specificity of antigen recognition

28 July 2018

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Degradation of T cell receptor (TCR)-CD3-zeta complexes after antigenic stimulation

28 July 2018

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Effects of epitope modification on T cell receptor-ligand binding and antigen recognition by seven H-2Kd-restricted cytotoxic T lymphocyte clones specific for a photoreactive peptide derivative

28 July 2018

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Antigen-specific T-cell receptors and their reactions with complexes formed by peptides with major histocompatibility complex proteins

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Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton

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Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

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The efficiency of antigen recognition by CD8+ CTL clones is determined by the frequency of serial TCR engagement.

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From TCR Engagement to T Cell Activation

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12 December 2020

Activated TCRs remain marked for internalization after dissociation from pMHC

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12 December 2020

Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation

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12 December 2020

Point mutations in the beta chain CDR3 can alter the T cell receptor recognition pattern on an MHC class I/peptide complex over a broad interface area

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12 December 2020

High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling

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12 December 2020

Serial TCR engagement and down-modulation by peptide:MHC molecule ligands: relationship to the quality of individual TCR signaling events

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12 December 2020

Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response

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12 December 2020

A simplified procedure for the preparation of MHC/peptide tetramers: chemical biotinylation of an unpaired cysteine engineered at the C-terminus of MHC-I

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Altered peptide ligand-mediated TCR antagonism can be modulated by a change in a single amino acid residue within the CDR3 beta of an MHC class I-restricted TCR

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Identifiers

DOI

10.1073/PNAS.0500922102

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15772168%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

0 references

1 reference

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9 January 2020

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