A screen for regulators of survival of motor neuron protein levels (Q33936321)

30 July 2017

title

A screen for regulators of survival of motor neuron protein levels (English)

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30 July 2017

8

Lance S Davidow

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30 July 2017

13

Lee L Rubin

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30 July 2017

Nina R Makhortova

1

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30 July 2017

Monica Hayhurst

2

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30 July 2017

Antonio Cerqueira

3

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30 July 2017

Amy D Sinor-Anderson

4

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30 July 2017

Wen-Ning Zhao

5

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30 July 2017

Patrick W Heiser

6

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30 July 2017

Anthony C Arvanites

7

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30 July 2017

Zachary O Waldon

9

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30 July 2017

Judith A Steen

10

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30 July 2017

Kelvin Lam

11

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30 July 2017

Hien D Ngo

12

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30 July 2017

publication date

19 June 2011

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30 July 2017

published in

Nature Chemical Biology

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30 July 2017

volume

7

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30 July 2017

issue

8

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30 July 2017

page(s)

544-552

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Targeting GSK-3 family members in the heart: a very sharp double-edged sword

30 July 2017

cites work

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A degron created by SMN2 exon 7 skipping is a principal contributor to spinal muscular atrophy severity

5 July 2018

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Regulation of protein stability by GSK3 mediated phosphorylation

5 July 2018

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A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog

5 July 2018

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Valproic acid blocks excitability in SMA type I mouse motor neurons

5 July 2018

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p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA binding protein HuR.

5 July 2018

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Spinal muscular atrophy: why do low levels of survival motor neuron protein make motor neurons sick?

5 July 2018

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A small molecule that directs differentiation of human ESCs into the pancreatic lineage.

5 July 2018

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Regulation of SMN protein stability

5 July 2018

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Modeling spinal muscular atrophy in Drosophila

5 July 2018

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Inactivation of the SMN complex by oxidative stress

5 July 2018

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A two-site ELISA can quantify upregulation of SMN protein by drugs for spinal muscular atrophy.

5 July 2018

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Where in the cell is the minor spliceosome?

5 July 2018

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Minor spliceosome components are predominantly localized in the nucleus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3236614

SMN deficiency causes tissue-specific perturbations in the repertoire of snRNAs and widespread defects in splicing

5 July 2018

1 reference

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Splicing segregation: the minor spliceosome acts outside the nucleus and controls cell proliferation

5 July 2018

1 reference

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Defective Ca2+ channel clustering in axon terminals disturbs excitability in motoneurons in spinal muscular atrophy

5 July 2018

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The selectivity of protein kinase inhibitors: a further update

5 July 2018

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Inhibitors of the sodium potassium ATPase that impair herpes simplex virus replication identified via a chemical screening approach

5 July 2018

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Trichostatin A increases SMN expression and survival in a mouse model of spinal muscular atrophy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3236614

Novel aminoglycosides increase SMN levels in spinal muscular atrophy fibroblasts

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3236614

Digitalis: new actions for an old drug

5 July 2018

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Glycogen synthase kinase 3beta inhibits myocardin-dependent transcription and hypertrophy induction through site-specific phosphorylation

5 July 2018

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Diverse small-molecule modulators of SMN expression found by high-throughput compound screening: early leads towards a therapeutic for spinal muscular atrophy.

5 July 2018

1 reference

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Structure-aided optimization of kinase inhibitors derived from alsterpaullone.

5 July 2018

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GSK3 inhibitors: development and therapeutic potential

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3236614

Smn, the spinal muscular atrophy-determining gene product, modulates axon growth and localization of beta-actin mRNA in growth cones of motoneurons

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3236614

Knockdown of the survival motor neuron (Smn) protein in zebrafish causes defects in motor axon outgrowth and pathfinding.

5 July 2018

1 reference

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Alsterpaullone, a novel cyclin-dependent kinase inhibitor, induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential

5 July 2018

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Directed differentiation of embryonic stem cells into motor neurons

5 July 2018

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Aclarubicin treatment restores SMN levels to cells derived from type I spinal muscular atrophy patients

5 July 2018

1 reference

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Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions

5 July 2018

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Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A

5 July 2018

1 reference

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A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3236614

A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3236614

Inactivation of the survival motor neuron gene, a candidate gene for human spinal muscular atrophy, leads to massive cell death in early mouse embryos

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3236614

Correlation between severity and SMN protein level in spinal muscular atrophy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3236614

A novel nuclear structure containing the survival of motor neurons protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3236614

Developmental expression of the platelet-derived growth factor alpha-receptor gene in mammalian central nervous system

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3236614

Identification and characterization of a spinal muscular atrophy-determining gene

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3236614

Protein kinase phosphorylation site sequences and consensus specificity motifs: tabulations

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3236614

Multiprotein complexes of the survival of motor neuron protein SMN with Gemins traffic to neuronal processes and growth cones of motor neurons

5 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.595

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.595

Degradation of survival motor neuron (SMN) protein is mediated via the ubiquitin/proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.595

Characterization of the neutralizing activity of digoxin-specific Fab toward ouabain-like steroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.595

Chelation of extracellular calcium-induced cell death was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.595

Ca++ distribution after Na+ pump inhibition in cultured neonatal rat myocardial cells

21 January 2018

1 reference

12 December 2020

SMN protein analysis in fibroblast, amniocyte and CVS cultures from spinal muscular atrophy patients and its relevance for diagnosis

1 reference

12 December 2020

SMNDelta7, the major product of the centromeric survival motor neuron (SMN2) gene, extends survival in mice with spinal muscular atrophy and associates with full-length SMN

1 reference

12 December 2020

Hypomorphic Smn knockdown C2C12 myoblasts reveal intrinsic defects in myoblast fusion and myotube morphology

1 reference

12 December 2020

Neurodevelopmental abnormalities in neurosphere-derived neural stem cells from SMN-depleted mice

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO.595

1 reference

Dimensions Publication ID

30 July 2017

0 references

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30 July 2017

1 reference