Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice (Q33937485)

30 July 2017

Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice (English)

1 reference

30 July 2017

0 references

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5

Maiken Nedergaard

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Temugin Berta

object named as

Temugin Berta

series ordinal

4

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Ru-Rong Ji

object named as

Ru-Rong Ji

series ordinal

6

0 references

Chul-Kyu Park

series ordinal

2

object named as

Chul-Kyu Park

1 reference

30 July 2017

3

Rou-Gang Xie

1 reference

30 July 2017

Gang Chen

1

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PubMed ID

24919967

30 July 2017

language of work or name

English

0 references

publication date

11 June 2014

1 reference

30 July 2017

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30 July 2017

137

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30 July 2017

Pt 8

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30 July 2017

2193-2209

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PubMed ID

24919967

describes a project that uses

30 July 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4107738/fullTextXML

inferred from PubMed Central ID database lookup

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Microglia: a promising target for treating neuropathic and postoperative pain, and morphine tolerance

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JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats

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JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain

5 July 2018

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Evidence for a role of connexin 43 in trigeminal pain using RNA interference in vivo

5 July 2018

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Connexin 43 hemichannels are permeable to ATP.

5 July 2018

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Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain

5 July 2018

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Chemokines and the pathophysiology of neuropathic pain

5 July 2018

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p38 MAPK, microglial signaling, and neuropathic pain

5 July 2018

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Signaling pathways in sensitization: toward a nociceptor cell biology

5 July 2018

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Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain

5 July 2018

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Glial-cytokine-neuronal interactions underlying the mechanisms of persistent pain

5 July 2018

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The impact of neuropathic pain on health-related quality of life: review and implications

5 July 2018

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Pannexin-1 couples to maitotoxin- and nigericin-induced interleukin-1beta release through a dye uptake-independent pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107738

A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107738

Connexin-based gap junction hemichannels: gating mechanisms

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107738

Neuropathic pain and spinal microglia: a big problem from molecules in "small" glia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107738

Immune regulation of central nervous system functions: from sickness responses to pathological pain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107738

Central sensitization and LTP: do pain and memory share similar mechanisms?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107738

P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107738

Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107738

Expression of the chemokine receptors CXCR1 and CXCR2 in rat oligodendroglial cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107738

Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107738

Expression of chemokine receptors by subsets of neurons in the central nervous system

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107738

Efficient analysis of experimental observations.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107738

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107738

Clinical trial of the p38 MAP kinase inhibitor dilmapimod in neuropathic pain following nerve injury.

5 July 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU140

Blocking connexin43 expression reduces inflammation and improves functional recovery after spinal cord injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU140

Epigenetic transcriptional activation of monocyte chemotactic protein 3 contributes to long-lasting neuropathic pain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU140

A randomized, double-blind, placebo-controlled trial of a chemokine receptor 2 (CCR2) antagonist in posttraumatic neuralgia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU140

Activation of Src-family kinases in spinal microglia contributes to mechanical hypersensitivity after nerve injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU140

P2Y12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU140

Analgesic efficacy and safety of the novel p38 MAP kinase inhibitor, losmapimod, in patients with neuropathic pain following peripheral nerve injury: a double-blind, placebo-controlled study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU140

Inhibition of Microglial Activation Attenuates the Development but Not Existing Hypersensitivity in a Rat Model of Neuropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU140

Effective reduction of neuronal death by inhibiting gap junctional intercellular communication in a rodent model of global transient cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU140

Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU140

Spinal gap junctions: potential involvement in pain facilitation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU140

Intercellular calcium signaling in astrocytes via ATP release through connexin hemichannels

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU140

P2Y12 receptors in spinal microglia are required for neuropathic pain after peripheral nerve injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU140

Differential regulation of the CXCR2 chemokine network in rat brain trauma: implications for neuroimmune interactions and neuronal survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU140

Effects of chronic administration of amitriptyline, gabapentin and minocycline on spinal brain-derived neurotrophic factor expression and neuropathic pain behavior in a rat chronic constriction injury model

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU140

Reopening of ATP-sensitive potassium channels reduces neuropathic pain and regulates astroglial gap junctions in the rat spinal cord.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU140

Spatial and temporal relationship between monocyte chemoattractant protein-1 expression and spinal glial activation following peripheral nerve injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU140

Expression of CCR2 in Both Resident and Bone Marrow-Derived Microglia Plays a Critical Role in Neuropathic Pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU140

p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107738

Functional hemichannels in astrocytes: a novel mechanism of glutamate release.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107738

The role of keratinocyte-derived chemokine (KC) on hyperalgesia caused by peripheral nerve injury in mice

29 October 2018

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12 December 2020

ATP-mediated glia signaling

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12 December 2020

CXCL12 secretion by bone marrow stromal cells is dependent on cell contact and mediated by connexin-43 and connexin-45 gap junctions.

1 reference

12 December 2020

Post-injury administration of minocycline: an effective treatment for nerve-injury induced neuropathic pain

1 reference

12 December 2020

Identifiers

DOI

10.1093/BRAIN/AWU140

1 reference

30 July 2017

1 reference

30 July 2017

1 reference

PubMed ID

24919967