Inhibition of human DNA polymerase beta activity by the anticancer prodrug Cloretazine (Q33943777)

30 July 2017

title

Inhibition of human DNA polymerase beta activity by the anticancer prodrug Cloretazine (English)

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30 July 2017

Abbie M Frederick

1

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30 July 2017

Marguerite L Davis

series ordinal

2

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30 July 2017

Kevin P Rice

series ordinal

3

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30 July 2017

language of work or name

English

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publication date

21 November 2008

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30 July 2017

number of pages

5

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Biochemical and Biophysical Research Communications

inferred from page(s)

published in

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30 July 2017

volume

378

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30 July 2017

issue

3

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30 July 2017

page(s)

419-423

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describes a project that uses

30 July 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2892842/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Lethality to leukemia cell lines of DNA interstrand cross-links generated by Cloretazine derived alkylating species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892842

A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification

5 July 2018

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Activities and mechanism of DNA polymerase beta

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892842

Mode of action of the chloroethylating and carbamoylating moieties of the prodrug cloretazine

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892842

The antineoplastic efficacy of the prodrug Cloretazine is produced by the synergistic interaction of carbamoylating and alkylating products of its activation

5 July 2018

1 reference

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Phase I study of cloretazine (VNP40101M), a novel sulfonylhydrazine alkylating agent, combined with cytarabine in patients with refractory leukemia

5 July 2018

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Role of O6-alkylguanine-DNA alkyltransferase in the cytotoxic activity of cloretazine

5 July 2018

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A phase I and pharmacokinetic study of VNP40101M, a new alkylating agent, in patients with advanced or metastatic cancer

5 July 2018

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A Phase I and pharmacokinetic study of VNP40101M, a novel sulfonylhydrazine alkylating agent, in patients with refractory leukemia

5 July 2018

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The base excision repair: mechanisms and its relevance for cancer susceptibility

5 July 2018

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Pharmacokinetics, mass balance, and tissue distribution of a novel DNA alkylating agent, VNP40101M, in rat

5 July 2018

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Hypersensitivity of DNA polymerase beta null mouse fibroblasts reflects accumulation of cytotoxic repair intermediates from site-specific alkyl DNA lesions

5 July 2018

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DNA polymerase beta is the major dRP lyase involved in repair of oxidative base lesions in DNA by mammalian cell extracts

5 July 2018

1 reference

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The lyase activity of the DNA repair protein beta-polymerase protects from DNA-damage-induced cytotoxicity

5 July 2018

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Repair of O(6)-alkylguanine by alkyltransferases

5 July 2018

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Comparison of DNA lesions produced by tumor-inhibitory 1,2-bis(sulfonyl)hydrazines and chloroethylnitrosoureas

5 July 2018

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Cells deficient in DNA polymerase beta are hypersensitive to alkylating agent-induced apoptosis and chromosomal breakage

5 July 2018

1 reference

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3'-Azido-3'-deoxythymidine-resistant mutants of DNA polymerase beta identified by in vivo selection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892842

The role of isocyanates in the toxicity of antitumour haloalkylnitrosoureas

5 July 2018

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DNA adducts and DNA damage by antineoplastic and carcinogenic N-nitrosocompounds

5 July 2018

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Differences in DNA alkylation products formed in sensitive and resistant human glioma cells treated with N-(2-chloroethyl)-N-nitrosourea

5 July 2018

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Relationship of structure to anticancer activity and toxicity of the nitrosoureas in animal systems

5 July 2018

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Evaluation of the role of isocyanates in the action of therapeutic nitrosoureas

5 July 2018

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Inhibition of rat liver DNA polymerase by nitrosoureas and isocyanates

5 July 2018

1 reference

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Differential inhibition of cellular glutathione reductase activity by isocyanates generated from the antitumor prodrugs Cloretazine and BCNU.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892842

1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (VNP40101M): I. Direct inhibition of O6-alkylguanine-DNA alkyltransferase (AGT) by electrophilic species generated by decomposition

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892842

1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (VNP40101M): II. Role of O6-alkylguanine-DNA alkyltransferase in cytotoxicity

29 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2892842

Inhibition of DNA repair by the 1,3-bis(2-chloroethyl)-1-nitrosourea breakdown product, 2-chloroethyl isocyanate

29 October 2018

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12 December 2020

Mechanism of action of the nitrosoureas--IV. Reactions of bis-chloroethyl nitrosourea and chloroethyl cyclohexyl nitrosourea with deoxyribonucleic acid

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12 December 2020

Antitumor 2-(aminocarbonyl)-1,2-bis(methylsulfonyl)-1-(2-chloroethyl)- hydrazines

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12 December 2020

Human DNA polymerase beta deoxyribose phosphate lyase. Substrate specificity and catalytic mechanism

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12 December 2020

Bendamustine and cloretazine: alkylators with sharply contrasting activity in AML

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12 December 2020

10.1016/J.BBRC.2008.11.042

Identifiers

DOI

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30 July 2017

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30 July 2017

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